公开(公告)号：US11493512B2

公开(公告)日：2022-11-08

申请号：US15373669

申请日：2016-12-09

Applicant: Laboratory Corporation of America Holdings

Inventor： Paul Scott Eastman ,  Eric Sasso

IPC: G01N33/564 ,  G01N33/68 ,  G16B25/00 ,  G16B20/00 ,  G16B25/10 ,  G16B20/20 ,  G16H50/50

Abstract: Biomarkers useful for diagnosing and assessing inflammatory disease activity, for prediction of risk for progressive spinal and joint damage, in particular for axial spondyloarthritis (axSpA) and ankylosing spondylitis (AS), and for generating a dataset are provided, along with kits for measuring expression of the biomarkers. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples.

公开(公告)号：US20240295553A1

公开(公告)日：2024-09-05

申请号：US18424298

申请日：2024-01-26

Applicant: Laboratory Corporation of America Holdings

Inventor： Paul Scott Eastman ,  Eric Sasso

IPC: G01N33/564 ,  C12Q1/6883 ,  G09B7/00 ,  G16B40/00 ,  G16B40/20

CPC classification number: G01N33/564 ,  C12Q1/6883 ,  G09B7/00 ,  G16B40/20 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N2800/102 ,  G01N2800/56 ,  G01N2800/60 ,  G16B40/00

Abstract: Biomarkers useful for assessing inflammatory disease or flare activity, in particular in juvenile idiopathic arthritis, are provided, along with kits for measuring expression of the biomarkers. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples.

公开(公告)号：US20220057395A1

公开(公告)日：2022-02-24

申请号：US17464110

申请日：2021-09-01

Applicant: Laboratory Corporation of America Holdings

Inventor： Paul Scott Eastman ,  William Manning

IPC: G01N33/564

Abstract: Provided herein are methods for assessing response to inflammatory disease therapy. The methods include performing immunoassays to generate scores based on quantitative data for expression of biomarkers relating to inflammatory biomarkers to assess disease activity in inflammatory diseases, e.g., rheumatoid arthritis. Also provided are uses of inflammatory biomarkers for guiding treatment decisions.

公开(公告)号：US20220057394A1

公开(公告)日：2022-02-24

申请号：US17464061

申请日：2021-09-01

Applicant: Laboratory Corporation of America Holdings

Inventor： Paul Scott Eastman ,  Eric Sasso

IPC: G01N33/564 ,  G01N33/68 ,  G16B25/00 ,  G16B20/00 ,  G16B25/10 ,  G16B20/20 ,  G16H50/50

Abstract: Biomarkers useful for diagnosing and assessing inflammatory disease activity, for prediction of risk for progressive spinal and joint damage, in particular for axial spondyloarthritis (axSpA) and ankylosing spondylitis (AS), and for generating a dataset are provided, along with kits for measuring expression of the biomarkers. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples.