公开(公告)号：US20220089719A1

公开(公告)日：2022-03-24

申请号：US17309955

申请日：2020-01-07

申请人： LabyRx Immunologic Therapeutics (USA) Limited

发明人： Michael BABICH ,  James A. RADOSEVICH

IPC分类号： C07K16/28 ,  A61K35/17 ,  G01N33/574

摘要： Constructs comprising an antibody moiety that specifically binds to Labyrinthin or a portion thereof and an effector domain are provided. Also provided are methods of making and using these constructs and compositions thereof.

公开(公告)号：US20220409709A1

公开(公告)日：2022-12-29

申请号：US17309648

申请日：2019-12-13

申请人： LABYRX IMMUNOLOGIC THERAPEUTICS (USA) LIMITED

发明人： James A. RADOSEVICH ,  Michael BABICH

IPC分类号： A61K39/00 ,  A61P35/00 ,  C07K14/47 ,  C07K5/083 ,  C07K5/093 ,  C07K5/103

摘要： Antigenic compositions comprising one or more labyrinthin-derived peptides are described herein. In some embodiment, each peptide of the antigenic composition comprises a T-cell epitope and/or a B-cell epitope. In other aspects, the present disclosure provides, e.g., vaccine compositions comprising tin antigenic composition disclosed herein, including kits, medicines, and compositions (such as pharmaceutical compositions and unit dosages) thereof. Also provided are methods of using the compositions disclosed herein, such as methods of treatment thereof and methods of producing antibodies, and antibody compositions thereof, against the one or more labyrinthin-derived peptides or a portion thereof.