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23 条记录 (耗时 0.064 秒)

    Androgen modulators
    7.
    发明授权
    Androgen modulators 失效
    雄激素调节剂

    公开(公告)号：US07473711B2

    公开(公告)日：2009-01-06

    申请号：US10599719

    申请日：2005-04-15

    申请人： Lain-Yen Hu ,  Huangshu Lei ,  Daniel Y. Du ,  Bruce A. Lefker

    发明人： Lain-Yen Hu ,  Huangshu Lei ,  Daniel Y. Du ,  Bruce A. Lefker

    IPC分类号： A61K31/085 ,  C07D255/50

    CPC分类号： C07C255/54 ,  C07C2601/02

    摘要： The present invention is directed to a class of 4-cyano-phenoxy derivatives of formula I and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.

    摘要翻译： 本发明涉及一类式I的4-氰基 - 苯氧基衍生物及其作为雄激素受体调节剂的用途。 本发明的其它方面涉及这些化合物用于减少过量的皮脂分泌和刺激毛发生长的用途。

    Androgen receptor modulators
    8.
    发明申请
    Androgen receptor modulators 审中-公开
    雄激素受体调节剂

    公开(公告)号：US20070129409A1

    公开(公告)日：2007-06-07

    申请号：US10580078

    申请日：2004-11-08

    申请人： Lain-Yen Hu ,  Daniel Du ,  Huangshu Lei ,  Wen-Song Yue

    发明人： Lain-Yen Hu ,  Daniel Du ,  Huangshu Lei ,  Wen-Song Yue

    IPC分类号： C07D213/84 ,  A61K31/44

    CPC分类号： C07D213/85

    摘要： The present invention is directed to a new class of 5-cyano-2-amino pyridines and to their use as androgen receptor modulators. A further aspect of the invention is directed to a new animal model for finding compounds capable of alleviating androgenic alopecia.

    摘要翻译： 本发明涉及一类新的5-氰基-2-氨基吡啶并且其用作雄激素受体调节剂。 本发明的另一方面涉及一种用于发现能够减轻雄激素性脱发的化合物的新动物模型。

    Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of neurodegenerative diseases
    10.
    发明授权
    Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of neurodegenerative diseases 失效
    支链氨基酸依赖性氨基转移酶抑制剂及其在治疗神经退行性疾病中的应用

    公开(公告)号：US06809119B2

    公开(公告)日：2004-10-26

    申请号：US10304803

    申请日：2002-11-26

    申请人： Lain-Yen Hu ,  Suzanne Ross Kesten ,  Huangshu Lei ,  Todd Robert Ryder ,  David Juergen Wustrow

    发明人： Lain-Yen Hu ,  Suzanne Ross Kesten ,  Huangshu Lei ,  Todd Robert Ryder ,  David Juergen Wustrow

    IPC分类号： A61K3118

    CPC分类号： C07C311/49 ,  C07C2601/14

    摘要： The invention relates to BCAT inhibitors and the use thereof for treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and Down's syndrome, treating or preventing the adverse consequences of the overstimulation of the excitatory amino acids, treating anxiety, psychosis, convulsions, aminoglycoside antibiotics-induced hearing loss, migraine headache, chronic pain, neuropathic pain, Parkinson's disease, diabetic retinopathy, glaucoma, CMV retinitis, urinary incontinence, opioid tolerance or withdrawal, and inducing anesthesia, as well as for enhancing cognition.

    摘要翻译： 本发明涉及BCAT抑制剂及其用于治疗或预防与中风，缺血，CNS创伤，低血糖和手术相关的神经元损失以及治疗包括阿尔茨海默病，肌萎缩性侧索硬化，亨廷顿病和唐氏综合征的神经变性疾病的治疗或治疗 或预防兴奋性氨基酸过度刺激的不良后果，治疗焦虑症，精神病，抽搐，氨基糖苷类抗生素诱发的听力损失，偏头痛，慢性疼痛，神经性疼痛，帕金森病，糖尿病性视网膜病变，青光眼，CMV视网膜炎，尿失禁 ，阿片类药物耐受或戒断，诱导麻醉以及增强认知功能。