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公开(公告)号：US07670613B2
公开(公告)日：2010-03-02
申请号：US11175097
申请日：2005-07-05
申请人： Lain-Yen Hu , Bruce A. Lefker , Daniel Y. Du , Yvonne Dorothy Smith , Huangshu Lei , William Glen Harter , Victoria Leigh Downs , Mark L. Boys , Donna Michele Iula
发明人： Lain-Yen Hu , Bruce A. Lefker , Daniel Y. Du , Yvonne Dorothy Smith , Huangshu Lei , William Glen Harter , Victoria Leigh Downs , Mark L. Boys , Donna Michele Iula
IPC分类号： A61K9/00
CPC分类号： C07C255/54 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42
摘要： The present invention is directed to a new class of 4-cycloalkoxy benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
摘要翻译： 本发明涉及一类新的4-环烷氧基苯并腈及其作为雄激素受体调节剂的用途。 本发明的其它方面涉及这些化合物用于减少过量的皮脂分泌和刺激毛发生长的用途。
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公开(公告)号：US20100048517A1
公开(公告)日：2010-02-25
申请号：US12546103
申请日：2009-11-05
申请人： Lain-Yen Hu , Bruce A. Lefker , Daniel Y. Du , Yvonne Dorothy Smith , Huangshu Lei , William Glen Harter , Victoria Leigh Downs , Mark L. Boys , Donna Michele Iula
发明人： Lain-Yen Hu , Bruce A. Lefker , Daniel Y. Du , Yvonne Dorothy Smith , Huangshu Lei , William Glen Harter , Victoria Leigh Downs , Mark L. Boys , Donna Michele Iula
IPC分类号： A61K31/655 , C07C255/00
CPC分类号： C07C255/54 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42
摘要： The present invention is directed to a new class of 4-cycloalkoxy benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
摘要翻译： 本发明涉及一类新的4-环烷氧基苯并腈及其作为雄激素受体调节剂的用途。 本发明的其它方面涉及这些化合物用于减少过量的皮脂分泌和刺激毛发生长的用途。
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公开(公告)号：US20090192202A1
公开(公告)日：2009-07-30
申请号：US12367887
申请日：2009-02-09
申请人： Lain-Yen Hu , Huangshu Lei , Daniel Y. Du , Bruce A. Lefker , Yvonne Dorothy Smith , Victor Fedij
发明人： Lain-Yen Hu , Huangshu Lei , Daniel Y. Du , Bruce A. Lefker , Yvonne Dorothy Smith , Victor Fedij
IPC分类号： A61K31/165 , C07C237/20 , C07D213/57 , A61K31/44 , A61P17/00
CPC分类号： C07C255/54 , C07C323/41 , C07C2601/02 , C07C2602/08 , C07D209/16 , C07D213/40 , C07D285/01 , C07D307/52 , C07D307/81 , C07D311/76 , C07D317/58 , C07D333/20 , C07D471/04
摘要： The present invention is directed to a new class of 4-cyano-phenoxy-alkyl carboxyl derivatives and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
摘要翻译： 本发明涉及一类新的4-氰基 - 苯氧基 - 烷基羧基衍生物及其作为雄激素受体调节剂的用途。 本发明的其它方面涉及这些化合物用于减少过量的皮脂分泌和刺激毛发生长的用途。
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公开(公告)号：US07507860B2
公开(公告)日：2009-03-24
申请号：US10599143
申请日：2005-04-01
申请人： Lain-Yen Hu , Huangshu Lei , Daniel Y. Du , Bruce A. Lefker , Yvonne Dorothy Smith , Victor Fedij
发明人： Lain-Yen Hu , Huangshu Lei , Daniel Y. Du , Bruce A. Lefker , Yvonne Dorothy Smith , Victor Fedij
IPC分类号： C07C211/08
CPC分类号： C07C255/54 , C07C323/41 , C07C2601/02 , C07C2602/08 , C07D209/16 , C07D213/40 , C07D285/01 , C07D307/52 , C07D307/81 , C07D311/76 , C07D317/58 , C07D333/20 , C07D471/04
摘要： The present invention is directed to a new class of 4-cyano-phenoxy-alkyl carboxyl derivatives and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
摘要翻译： 本发明涉及一类新的4-氰基 - 苯氧基 - 烷基羧基衍生物及其作为雄激素受体调节剂的用途。 本发明的其它方面涉及这些化合物用于减少过量的皮脂分泌和刺激毛发生长的用途。
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公开(公告)号：US07576128B2
公开(公告)日：2009-08-18
申请号：US11053010
申请日：2005-02-08
申请人： Lain-Yen Hu , Huangshu Lei , Daniel Y. Du , Bruce A. Lefker
发明人： Lain-Yen Hu , Huangshu Lei , Daniel Y. Du , Bruce A. Lefker
IPC分类号： A61K31/277 , C07C255/49
CPC分类号： C07C255/54
摘要： The present invention is directed to a new class of 4-oxo-benzonitriles, their use as androgen modulators, and to their use in the treatment of alopecia.
摘要翻译： 本发明涉及一类新的4-氧代 - 苯甲腈，它们用作雄激素调节剂，以及它们在治疗脱发中的用途。
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公开(公告)号：US07473711B2
公开(公告)日：2009-01-06
申请号：US10599719
申请日：2005-04-15
申请人： Lain-Yen Hu , Huangshu Lei , Daniel Y. Du , Bruce A. Lefker
发明人： Lain-Yen Hu , Huangshu Lei , Daniel Y. Du , Bruce A. Lefker
IPC分类号： A61K31/085 , C07D255/50
CPC分类号： C07C255/54 , C07C2601/02
摘要： The present invention is directed to a class of 4-cyano-phenoxy derivatives of formula I and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
摘要翻译： 本发明涉及一类式I的4-氰基 - 苯氧基衍生物及其作为雄激素受体调节剂的用途。 本发明的其它方面涉及这些化合物用于减少过量的皮脂分泌和刺激毛发生长的用途。
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公开(公告)号：US07674819B2
公开(公告)日：2010-03-09
申请号：US11415935
申请日：2006-05-02
申请人： Stephen Douglas Barrett , Victor Fedij , Lain-Yen Hu , Donna M. Iula , Bruce A. Lefker , Raj Kumar Raheja , Karen Sexton , Jennifer Ann Van Camp
发明人： Stephen Douglas Barrett , Victor Fedij , Lain-Yen Hu , Donna M. Iula , Bruce A. Lefker , Raj Kumar Raheja , Karen Sexton , Jennifer Ann Van Camp
IPC分类号： A61K31/40 , C07D207/04
CPC分类号： C07D207/273 , C07D207/27 , C07D401/06 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The present invention is directed to a new class of benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
摘要翻译： 本发明涉及一类新的苯腈和它们作为雄激素受体调节剂的用途。 本发明的其它方面涉及这些化合物用于减少过量的皮脂分泌和刺激毛发生长的用途。
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公开(公告)号：US07192979B2
公开(公告)日：2007-03-20
申请号：US10668633
申请日：2003-09-23
IPC分类号： A61K31/4015 , C07D207/04
CPC分类号： C07D403/06 , C07D207/20 , C07D405/10 , C07D409/06 , C07D409/14 , C07D417/06
摘要： This invention is directed to EP4 receptor selective prostaglandin agonists of the Formula I, wherein R2, X, Z and Q are as defined in the specification. This invention is also directed to pharmaceutical compositions containing those compounds. This invention is also directed to methods of treating conditions which present with low bone mass, particularly osteoporosis, frailty, an osteoporotic fracture, a bone defect, childhood idiopathic bone loss, alveolar bone loss, mandibular bone loss, bone fracture, osteotomy, bone loss associated with periodontitis, or prosthetic ingrowth in a mammal comprising administering those compounds.
摘要翻译： 本发明涉及式I的EP4受体选择性前列腺素激动剂，其中R 2，X，Z和Q如说明书中所定义。 本发明还涉及含有这些化合物的药物组合物。 本发明还涉及治疗具有低骨量，特别是骨质疏松症，脆弱性，骨质疏松性骨折，骨缺损，儿童特发性骨丢失，牙槽骨丢失，下颌骨骨丢失，骨折，截骨术，骨丢失 与哺乳动物中的牙周炎或假体向内生长相关，包括施用那些化合物。
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公开(公告)号：US06649657B2
公开(公告)日：2003-11-18
申请号：US10256985
申请日：2002-09-26
IPC分类号： A61K31235
CPC分类号： C07D207/263 , A61K45/06 , C07C235/34 , C07C311/04 , C07C311/06 , C07C323/49 , C07C2601/14 , C07C2602/08 , C07D209/14 , C07D213/42 , C07D215/18 , C07D239/26 , C07D241/12 , C07D249/06 , C07D257/04 , C07D271/12 , C07D277/28 , C07D277/56 , C07D307/24 , C07D307/52 , C07D307/68 , C07D307/81 , C07D317/58 , C07D319/18 , C07D333/20 , C07D333/24 , C07D333/34 , C07D333/38 , C07D409/12
摘要： Prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for the treatment of bone disorders including osteoporosis.
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公开(公告)号：US5442044A
公开(公告)日：1995-08-15
申请号：US28038
申请日：1993-03-08
IPC分类号： A61K38/00 , C07D211/58 , C07D401/12 , C07D409/12 , C07D417/12 , C07K5/02 , C07K5/065 , C07K5/06 , A61K38/05
CPC分类号： C07D401/12 , C07D211/58 , C07D409/12 , C07D417/12 , C07K5/0202 , C07K5/06078 , A61K38/00
摘要： This invention relates to compounds of the formula ##STR1## wherein Q, Z, D, E, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are defined as below, and the pharmaceutically acceptable salts thereof are disclosed. The compounds are useful as antihypertensive agents.
摘要翻译： 本发明涉及下式的化合物，其中Q，Z，D，E，R 3，R 4，R 5和R 6如下定义，其药学上可接受的盐被公开。 该化合物可用作抗高血压药。
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