公开(公告)号：US20190106464A1

公开(公告)日：2019-04-11

申请号：US16085959

申请日：2017-03-17

Applicant: Lallemand Hungary Liquidity Management LLC

Inventor： Michelle Oeser ,  Brooks Henningsen ,  Janet Fisher ,  Charles F. Rice ,  Allan Froehlich ,  Aaron Argyros ,  Rintze M. Zelle

IPC: C07K14/395 ,  C12N15/52 ,  C12N1/22 ,  C12N15/113 ,  C12P7/06 ,  C12N15/81

Abstract: The present disclosure relates to the modulation in the RAS/cAMP/PKA signaling pathway for maintaining the propagation efficiency and increasing fermentation efficiency of yeast cells. The present disclosure provides yeast cells having or engineered to exhibit a modulation in signaling in a RAS/cAMP/PKA pathway, depending on conditions. For example the yeast cells can be selected or genetically modified to express a mutated Ras1 protein, a mutated Ras2 protein, a mutated Ira1 protein and/or a mutated Ira2 protein, optionally in combination with specific promoters. Also provided herewith are methods for propagating the yeast cells as well as using the yeast cells to generate a fermented product (such as ethanol).

公开(公告)号：US20200087672A1

公开(公告)日：2020-03-19

申请号：US16493245

申请日：2018-03-13

Applicant: Lallemand Hungary Liquidity Management LLC

Inventor： Aaron Argyros ,  Michelle Oeser ,  Erin Wiswall ,  Janet Fisher ,  Johannes Van Eijk ,  J. Kevin Kraus ,  Kevin Wenger ,  Brooks Henningsen ,  Ryan Skinner

IPC: C12N15/81 ,  A21D8/04 ,  A23K10/18 ,  A23K20/189 ,  A23L33/14 ,  C12N1/18 ,  C12N9/16 ,  C12N9/30 ,  C12N9/34

Abstract: The present disclosure concerns recombinant yeast host cells expressing cell-associated heterologous food and/or feed enzymes which are expressed during the propagation phase of the recombinant yeast hosts cells. The recombinant yeast host cells can be used in a subsequent production process to make food and/or feed products, for example, baked products.

公开(公告)号：US11667680B2

公开(公告)日：2023-06-06

申请号：US16085959

申请日：2017-03-17

Applicant: Lallemand Hungary Liquidity Management LLC

Inventor： Michelle Oeser ,  Brooks Henningsen ,  Janet Fisher ,  Charles F. Rice ,  Allan Froehlich ,  Aaron Argyros ,  Rintze M. Zelle

IPC: C07K14/395 ,  C12N1/22 ,  C12P7/06 ,  C12N15/113 ,  C12N15/52 ,  C12N15/81

CPC classification number: C07K14/395 ,  C12N1/22 ,  C12N15/113 ,  C12N15/52 ,  C12N15/815 ,  C12P7/06 ,  C12P7/065 ,  Y02E50/10

Abstract: The present disclosure relates to the modulation in the RAS/cAMP/PKA signaling pathway for maintaining the propagation efficiency and increasing fermentation efficiency of yeast cells. The present disclosure provides yeast cells having or engineered to exhibit a modulation in signaling in a RAS/cAMP/PKA pathway, depending on conditions. For example the yeast cells can be selected or genetically modified to express a mutated Ras1 protein, a mutated Ras2 protein, a mutated Ira1 protein and/or a mutated Ira2 protein, optionally in combination with specific promoters. Also provided herewith are methods for propagating the yeast cells as well as using the yeast cells to generate a fermented product (such as ethanol).

公开(公告)号：US20220090102A1

公开(公告)日：2022-03-24

申请号：US16472742

申请日：2017-12-22

Applicant: Lallemand Hungary Liquidity Management LLC

Inventor： Aaron Argyros ,  Charles F. Rice ,  Trisha Barrett ,  Michelle Oeser ,  Janet Fisher

IPC: C12N15/81 ,  C12N1/18

Abstract: The present disclosure concerns the use of specific genetic modification(s) for improving sulfite tolerance in recombinant yeast host cells. The genetic modification(s) is (are) designed to allow the expression of an heterologous transcription factor favoring the expression of a SSU1 polypeptide and/or the expression of an heterologous SSU1 polypeptide in the recombinant yeast host cell(s).

公开(公告)号：US20220127564A1

公开(公告)日：2022-04-28

申请号：US16493595

申请日：2018-03-13

Applicant: Lallemand Hungary Liquidity Management LLC

Inventor： Aaron Argyros ,  Michelle Oeser ,  Erin Wiswall ,  Janet Fisher ,  Johannes Van Eijk ,  J. Kevin Kraus ,  Kevin Wenger ,  Brooks Henningsen ,  Ryan Skinner

IPC: C12N1/18 ,  C12P21/02 ,  C12N1/06 ,  C12N9/00

Abstract: The present disclosure concerns recombinant yeast host cells expressing cell-associated heterologous proteins which are expressed during the propagation phase of the recombinant yeast host cells and processes for propagating same. The recombinant yeast host cells can be 5 used to make a yeast composition or a yeast product enriched in the heterologous proteins.