公开(公告)号：US20120117018A1

公开(公告)日：2012-05-10

申请号：US13255490

申请日：2010-03-10

Applicant: Lance D. Miller ,  Krishna Murthy Karuturi

Inventor： Lance D. Miller ,  Krishna Murthy Karuturi

IPC: G06N5/04

CPC classification number: C12Q1/6837 ,  C12Q1/6886 ,  C12Q2600/118 ,  G16B20/00 ,  G16B25/00 ,  G16B40/00

Abstract: A method is proposed identification of pairs of genes for which the respective gene expression values in a subject are statistically significant in relation to a medical condition, for example cancer, or more particularly breast cancer. Many pairs of genes are generated, and for each pair of genes clinical data is used to fit a statistical model to obtain the statistical significance of the ratio of the corresponding expression values. The clinical data characterizes for each of the patients the level of expressions of the genes and times until a clinical endpoint of interest.

Abstract translation: 提出了一种方法，鉴定对象中各个基因表达值相对于医学状况（例如癌症，或更特别是乳腺癌）具有统计学意义的基因对。 生成多对基因，对于每一对基因，临床资料用于拟合统计学模型，以获得相应表达值比值的统计学显着性。 临床数据表征每个患者的基因表达水平和直到临床终点为止的时间。