专利检索 ap:("Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences") AND inv:"Kangli LI" 第 1 页

1.

发明申请
Recombinant foot-and-mouth disease virus with reduced immunosuppression activity, and preparation method and use thereof 有权

公开(公告)号：US20220017576A1

公开(公告)日：2022-01-20

申请号：US17375203

申请日：2021-07-14

申请人： Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences

发明人： Haixue ZHENG , Fan YANG , Zixiang ZHU , Xiangle ZHANG , Weijun CAO , Congcong WANG , Kangli LI , Huisheng LIU , Hong TIAN , Keshan ZHANG , Xiangtao LIU

IPC分类号： C07K14/005 , C12N7/00 , A61P31/14 , A61K39/135 , A61P37/06

摘要： The present disclosure belongs to the technical field of biological products for veterinary medicine, and specifically relates to a recombinant foot-and-mouth disease virus (FMDV) with a reduced immunosuppressive activity, a preparation method and use thereof, and a recombinant vaccine strain. According to the present disclosure, it is firstly discovered that FMDV 3B protein has an immunosuppressive function, and key sites for exerting the immunosuppressive function are found. A recombinant FMDV vaccine strain with a lost immunosuppressive function in FMDV 3B protein is constructed by introducing amino acid mutations into three repeated copies of FMDV 3B protein.