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    Color coated layer-by-layer microcapsules serving as combinatory analysis libraries and as specific optical sensors
    1.
    发明申请
    Color coated layer-by-layer microcapsules serving as combinatory analysis libraries and as specific optical sensors 审中-公开
    作为组合分析库和特定光学传感器的彩色涂层逐层微胶囊

    公开(公告)号：US20060105335A1

    公开(公告)日：2006-05-18

    申请号：US10522998

    申请日：2003-07-29

    申请人： Lars Daehne ,  Barbara Baude ,  Andreas Voigt

    发明人： Lars Daehne ,  Barbara Baude ,  Andreas Voigt

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  C12M1/34 ,  C40B40/10

    CPC分类号： G01N33/587 ,  B01J13/02 ,  B01J13/22 ,  B01J2219/005 ,  B01J2219/00576 ,  C40B99/00

    摘要： Monodisperse colloids were coated with polyelectrolytes using the layer-by-layer method. The template cores can remain in the interior or be dissolved away. Various fluorescent dyes are covalently bonded, in defined quantity, to the polyelectrolytes. The quantity of dye is controlled by varying the label content or by coprecipitating unlabeled polymers. Different. dye layers are separated from each other by intermediate layers, resulting in unwanted interactions being suppressed. Conversely, a FRET signal can be generated between suitable dye pairs at short distances (0-6 nm), with it being possible to control this signal independently of the dye concentration by means of the number of intermediate layers. The capsule coding is read out by varying the excitation and emission wavelengths. Macromolecules which fish out complementary substances from solutions can be immobilized in the capsules. Particles which are coated in this way, or hollow capsules, can be used as sensors after a sensitive intermediate layer has been introduced. Changes in the size/structure of the intermediate layer can be detected either by FRET occurring between adjacent, labeled polyelectrolyte layers or by self-quenching/aggregate fluorescence of dyes in the sensitive layer.

    摘要翻译： 单分散胶体用聚电解质涂覆，使用逐层方法。 模板芯可以保留在内部或溶解掉。 各种荧光染料以规定的量与聚电解质共价键合。 通过改变标签含量或通过共沉淀未标记的聚合物来控制染料的量。 不同。 染料层通过中间层彼此分离，导致不希望的相互作用被抑制。 相反，可以在短距离（0-6nm）的合适的染料对之间产生FRET信号，可以通过中间层的数量独立于染料浓度来控制该信号。 通过改变激发和发射波长来读出胶囊编码。 从溶液中除去互补物质的大分子可以固定在胶囊中。 以这种方式涂覆的颗粒或中空胶囊可以在引入敏感中间层之后用作传感器。 中间层的尺寸/结构的变化可以通过在相邻的标记的聚电解质层之间发生的FRET或通过敏感层中的染料的自猝灭/聚集荧光来检测。

    Method for producing core-shell (CS) particles and microcapsules using porous templates, CS particles and microcapsules, and the use thereof
    3.
    发明授权
    Method for producing core-shell (CS) particles and microcapsules using porous templates, CS particles and microcapsules, and the use thereof 有权

    公开(公告)号：US07763279B2

    公开(公告)日：2010-07-27

    申请号：US10593353

    申请日：2005-03-16

    申请人： Lars Dahne ,  Barbara Baude

    发明人： Lars Dahne ,  Barbara Baude

    IPC分类号： A61K9/14

    摘要： A process for the production of CS particles (10) and microcapsules (12) is described, in which at least one active compound (4) is adsorbed in porous templates (2) (A), as a result of which templates (5) filled with active compounds are present. Subsequently, the templates (2) are provided (B) with a primer layer (6) which is intended to facilitate the subsequent construction of the capsule shell (9). The capsule shell is formed (C) by applying alternately charged polyelectrolyte layers (8). Filled CS particles (10) are obtained. By subsequent dissolution of the templates (2) the active compounds (4) are released (D) from the template into the interior of the microcapsules. The active compounds (4) remain enclosed there or are slowly released (E) from the capsule.

    Method for producing core-shell (CS) particles and microcapsules using porous templates, CS particles and microcapsules, and the use thereof
    4.
    发明授权
    Method for producing core-shell (CS) particles and microcapsules using porous templates, CS particles and microcapsules, and the use thereof 有权
    使用多孔模板，CS颗粒和微胶囊生产核 - 壳（CS）颗粒和微胶囊的方法及其用途

    公开(公告)号：US07939103B2

    公开(公告)日：2011-05-10

    申请号：US10593353

    申请日：2005-03-16

    申请人： Lars Dahne ,  Barbara Baude

    发明人： Lars Dahne ,  Barbara Baude

    IPC分类号： B32B5/16

    CPC分类号： A61K9/5078 ,  A61K9/5073 ,  B01J13/02 ,  Y10T428/2991

    摘要： A process for the production of CS particles (10) and microcapsules (12) is described, in which at least one active compound (4) is adsorbed in porous templates (2) (A), as a result of which templates (5) filled with active compounds are present. Subsequently, the templates (2) are provided (B) with a primer layer (6) which is intended to facilitate the subsequent construction of the capsule shell (9). The capsule shell is formed (C) by applying alternately charged polyelectrolyte layers (8). Filled CS particles (10) are obtained. By subsequent dissolution of the templates (2) the active compounds (4) are released (D) from the template into the interior of the microcapsules. The active compounds (4) remain enclosed there or are slowly released (E) from the capsule.

    摘要翻译： 描述了生产CS颗粒（10）和微胶囊（12）的方法，其中至少一种活性化合物（4）吸附在多孔模板（2）（A）中，其结果是模板（5） 填充有活性化合物。 随后，提供模板（2）（B）和底漆层（6），其旨在促进胶囊壳（9）的后续构造。 通过施加交替电荷的聚电解质层（8），形成胶囊壳（C）。 填充CS颗粒（10）。 通过随后的模板（2）的溶解，将活性化合物（4）从模板释放（D）到微胶囊的内部。 活性化合物（4）保持封闭在那里或从胶囊缓慢释放（E）。

    Method For Producing Cs Particles And Microcapsules Using Porous Templates, Cs Particles And Microcapsules, And the Use Thereof
    6.
    发明申请
    Method For Producing Cs Particles And Microcapsules Using Porous Templates, Cs Particles And Microcapsules, And the Use Thereof 有权
    使用多孔模板，Cs颗粒和微胶囊生产Cs颗粒和微胶囊的方法及其用途

    公开(公告)号：US20080020051A1

    公开(公告)日：2008-01-24

    申请号：US10593353

    申请日：2005-03-16

    申请人： Lars Dahne ,  Barbara Baude

    发明人： Lars Dahne ,  Barbara Baude

    IPC分类号： B32B5/16 ,  A61K9/50 ,  B05D7/00

    CPC分类号： A61K9/5078 ,  A61K9/5073 ,  B01J13/02 ,  Y10T428/2991

    摘要： A process for the production of CS particles (10) and microcapsules (12) is described, in which at least one active compound (4) is adsorbed in porous templates (2) (A), as a result of which templates (5) filled with active compounds are present. Subsequently, the templates (2) are provided (B) with a primer layer (6) which is intended to facilitate the subsequent construction of the capsule shell (9). The capsule shell is formed (C) by applying alternately charged polyelectrolyte layers (8). Filled CS particles (10) are obtained. By subsequent dissolution of the templates (2) the active compounds (4) are released (D) from the template into the interior of the microcapsules. The active compounds (4) remain enclosed there or are slowly released (E) from the capsule.

    摘要翻译： 描述了生产CS颗粒（10）和微胶囊（12）的方法，其中至少一种活性化合物（4）吸附在多孔模板（2）（A）中，其结果是模板（5） 填充有活性化合物。 随后，提供模板（2）（B）和底漆层（6），其旨在促进胶囊壳（9）的后续构造。 通过施加交替电荷的聚电解质层（8），形成胶囊壳（C）。 填充CS颗粒（10）。 通过随后的模板（2）的溶解，将活性化合物（4）从模板释放（D）到微胶囊的内部。 活性化合物（4）保持封闭在那里或从胶囊缓慢释放（E）。