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公开(公告)号:US20090148396A1
公开(公告)日:2009-06-11
申请号:US12276856
申请日:2008-11-24
申请人: Laura C. AKULLIAN , Russell C. PETTER , John J. KANE , Charles E. HAMMOND , Mao YIN , Aleksandr YURKOVETSKIY , Cheri A. STEVENSON
发明人: Laura C. AKULLIAN , Russell C. PETTER , John J. KANE , Charles E. HAMMOND , Mao YIN , Aleksandr YURKOVETSKIY , Cheri A. STEVENSON
IPC分类号: A61K31/77 , C08F24/00 , C08F26/06 , A61P35/00 , A61K31/787
CPC分类号: C07D303/40 , A61K47/59 , C07D303/18 , C07D303/22 , C07D303/36 , C07D405/14 , C07D487/08
摘要: Fumagillin analog polymer conjugates, methods of making fumagillin analog polymer conjugates, compositions comprising a polymer conjugate of a fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a polymer conjugate of a fumagillin analog, are described. Also described are novel fumagillin analogs, methods of making fumagillin analogs, compositions comprising at least one fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a fumagillin analog.
摘要翻译: 烟曲霉素类似物聚合物缀合物,制备烟曲霉素类似物聚合物共轭物的方法,包含烟曲霉素类似物的聚合物缀合物的组合物,以及用于治疗癌症的方法或治疗血管发生疾病的方法,包括向有需要的受试者施用有效量的 烟曲霉素类似物。 还描述了新的烟曲霉素类似物,制备烟曲霉素类似物的方法,包含至少一种烟曲霉素类似物的组合物,以及用于治疗癌症的方法或治疗血管发生疾病,包括向有需要的受试者施用有效量的烟曲霉素类似物。