-
公开(公告)号：US20120321583A1
公开(公告)日：2012-12-20
申请号：US13493899
申请日：2012-06-11
申请人： Aleksandr Yurkovetskiy , Mao Yin , Timothy B. Lowinger , Joshua D. Thomas , Charles E. Hammond , Cheri A. Stevenson , Natalya D. Bodyak , Patrick R. Conlon , Dmitry R. Gumerov
发明人： Aleksandr Yurkovetskiy , Mao Yin , Timothy B. Lowinger , Joshua D. Thomas , Charles E. Hammond , Cheri A. Stevenson , Natalya D. Bodyak , Patrick R. Conlon , Dmitry R. Gumerov
IPC分类号： C08G65/333 , C08G65/332 , A61P35/00 , A61P35/02 , A61K47/48 , C07K5/103
CPC分类号： A61K47/59 , A61K31/4745 , A61K47/64 , A61K47/6803 , A61K47/6849 , A61K47/6883 , C07K7/02 , C07K16/32 , C08G65/33396 , C08G65/334
摘要： A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -LD-D, the protein based recognition-molecule being connected to the polymeric carrier by LP. Each occurrence of D is independently a therapeutic agent having a molecular weight ≦5 kDa. LD and LP are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.
摘要翻译： 本文提供药物缀合物。 缀合物包含基于蛋白质的识别分子（PBRM）和被一个或多个-LD-D取代的聚合物载体，基于蛋白质的识别分子通过LP连接到聚合物载体上。 每次出现的D独立地是具有分子量＆nlE; 5kDa的治疗剂。 LD和LP分别是将治疗剂和PBRM分别连接到聚合物载体的接头。 还公开了可用于与PBRM缀合以形成本文所述的聚合物 - 药物-PBRM缀合物的聚合物支架，包含缀合物的组合物，其制备方法，以及用缀合物或其组合物治疗各种病症的方法。
-
公开(公告)号：US06376538B1
公开(公告)日：2002-04-23
申请号：US08875321
申请日：1997-09-19
申请人： Steven P. Adams , Ko-Chung Lin , Wen-Cherng Lee , Alfredo C. Castro , Craig N. Zimmerman , Charles E. Hammond , Yu-Sheng Liao , Julio Hernan Cuervo , Juswinder Singh
发明人： Steven P. Adams , Ko-Chung Lin , Wen-Cherng Lee , Alfredo C. Castro , Craig N. Zimmerman , Charles E. Hammond , Yu-Sheng Liao , Julio Hernan Cuervo , Juswinder Singh
IPC分类号： A61K31357
CPC分类号： C07D213/75 , A61K38/00 , C07C237/22 , C07C255/19 , C07C271/22 , C07C275/28 , C07C275/42 , C07C275/54 , C07C311/06 , C07C311/21 , C07C317/50 , C07C323/60 , C07C2601/02 , C07C2601/14 , C07D209/42 , C07D213/55 , C07D215/48 , C07D277/48 , C07D317/60 , C07D405/12 , C07K7/06
摘要： The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.
摘要翻译： 本发明涉及可用于抑制和预防细胞粘附和细胞粘附介导的病理学的新型化合物。 本发明还涉及包含这些化合物的药物制剂及其用于抑制和预防细胞粘附和细胞粘附介导的病理学的方法。 本发明的化合物和药物组合物可用作治疗剂或预防剂。 它们特别适用于治疗许多炎性和自身免疫性疾病。
-
3.发明申请MODIFIED POLYMERS FOR DELIVERY OF POLYNUCLEOTIDES, METHOD OF MANUFACTURE, AND METHODS OF USE THEREOF 失效用于输送多核苷酸的改性聚合物，其制造方法及其使用方法公开(公告)号：US20110243880A1
公开(公告)日：2011-10-06
申请号：US13073815
申请日：2011-03-28
申请人： Aleksandr Yurkovetskiy , Mao Yin , Timothy B. Lowinger , Carolina B. Cabral , Charles E. Hammond , Cheri A. Stevenson
发明人： Aleksandr Yurkovetskiy , Mao Yin , Timothy B. Lowinger , Carolina B. Cabral , Charles E. Hammond , Cheri A. Stevenson
CPC分类号： C08L59/00 , A61K47/59 , A61K48/0041 , C12N15/111 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12N2320/32
摘要： A polynucleotide delivery vehicle comprising a modified polymer is provided herein, the modified polymer having the following formula: in which W1, W2, W3, W4, W5, W6, Z1, Z2, Z3, Z4, Z5, Z9, R1, R2, R3, R4, R5, n1, n2, n3, n4, n5, and n6 are defined herein. Also disclosed are methods of delivering a polynucleotide to the cytoplasm of a selected tissue type or cell type and methods of reducing expression of a gene in a cell or a subject in need thereof with the modified polymer.
摘要翻译： 本文提供了包含改性聚合物的多核苷酸递送载体，所述改性聚合物具有下式：其中W1，W2，W3，W4，W5，W6，Z1，Z2，Z3，Z4，Z5，Z9，R1，R2， R3，R4，R5，n1，n2，n3，n4，n5和n6在本文中定义。 还公开了将多核苷酸递送至所选组织类型或细胞类型的细胞质的方法以及在有需要的细胞或受试者中用改性聚合物降低基因表达的方法。
-
公开(公告)号：US20090148396A1
公开(公告)日：2009-06-11
申请号：US12276856
申请日：2008-11-24
申请人： Laura C. AKULLIAN , Russell C. PETTER , John J. KANE , Charles E. HAMMOND , Mao YIN , Aleksandr YURKOVETSKIY , Cheri A. STEVENSON
发明人： Laura C. AKULLIAN , Russell C. PETTER , John J. KANE , Charles E. HAMMOND , Mao YIN , Aleksandr YURKOVETSKIY , Cheri A. STEVENSON
IPC分类号： A61K31/77 , C08F24/00 , C08F26/06 , A61P35/00 , A61K31/787
CPC分类号： C07D303/40 , A61K47/59 , C07D303/18 , C07D303/22 , C07D303/36 , C07D405/14 , C07D487/08
摘要： Fumagillin analog polymer conjugates, methods of making fumagillin analog polymer conjugates, compositions comprising a polymer conjugate of a fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a polymer conjugate of a fumagillin analog, are described. Also described are novel fumagillin analogs, methods of making fumagillin analogs, compositions comprising at least one fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a fumagillin analog.
摘要翻译： 烟曲霉素类似物聚合物缀合物，制备烟曲霉素类似物聚合物共轭物的方法，包含烟曲霉素类似物的聚合物缀合物的组合物，以及用于治疗癌症的方法或治疗血管发生疾病的方法，包括向有需要的受试者施用有效量的 烟曲霉素类似物。 还描述了新的烟曲霉素类似物，制备烟曲霉素类似物的方法，包含至少一种烟曲霉素类似物的组合物，以及用于治疗癌症的方法或治疗血管发生疾病，包括向有需要的受试者施用有效量的烟曲霉素类似物。
-
公开(公告)号：US06630512B2
公开(公告)日：2003-10-07
申请号：US10002341
申请日：2001-10-23
申请人： Steven P. Adams , Ko-Chung Lin , Wen-Cherng Lee , Alfredo C. Castro , Craig N. Zimmerman , Charles E. Hammond , Yu-Sheng Liao , Julio Hernan Cuervo , Juswinder Singh
发明人： Steven P. Adams , Ko-Chung Lin , Wen-Cherng Lee , Alfredo C. Castro , Craig N. Zimmerman , Charles E. Hammond , Yu-Sheng Liao , Julio Hernan Cuervo , Juswinder Singh
IPC分类号： A61K31197
CPC分类号： C07D213/75 , A61K38/00 , C07C237/22 , C07C255/19 , C07C271/22 , C07C275/28 , C07C275/42 , C07C275/54 , C07C311/06 , C07C311/21 , C07C317/50 , C07C323/60 , C07C2601/02 , C07C2601/14 , C07D209/42 , C07D213/55 , C07D215/48 , C07D277/48 , C07D317/60 , C07D405/12 , C07K7/06
摘要： The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.
-
公开(公告)号：US06306840B1
公开(公告)日：2001-10-23
申请号：US08376372
申请日：1995-01-23
申请人： Steven P. Adams , Ko-Chung Lin , Wen-Cherng Lee , Alfredo C. Castro , Craig N. Zimmerman , Charles E. Hammond , Yu-Sheng Liao
发明人： Steven P. Adams , Ko-Chung Lin , Wen-Cherng Lee , Alfredo C. Castro , Craig N. Zimmerman , Charles E. Hammond , Yu-Sheng Liao
IPC分类号： A61K3136
CPC分类号： C07D213/75 , A61K38/00 , C07C237/22 , C07C255/19 , C07C271/22 , C07C275/28 , C07C275/42 , C07C275/54 , C07C311/06 , C07C311/21 , C07C317/50 , C07C323/60 , C07C2601/02 , C07C2601/14 , C07D209/42 , C07D213/55 , C07D215/48 , C07D277/48 , C07D317/60 , C07D405/12 , C07K7/06
摘要： The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.
-
公开(公告)号：US06248713B1
公开(公告)日：2001-06-19
申请号：US08498237
申请日：1995-07-11
申请人： Ko-Chung Lin , Steven P. Adams , Alfredo C. Castro , Craig N. Zimmerman , Julio Hernan Cuervo , Wen-Cherng Lee , Charles E. Hammond , Mary Beth Carter , Ronald G. Almquist
发明人： Ko-Chung Lin , Steven P. Adams , Alfredo C. Castro , Craig N. Zimmerman , Julio Hernan Cuervo , Wen-Cherng Lee , Charles E. Hammond , Mary Beth Carter , Ronald G. Almquist
IPC分类号： A61K3803
CPC分类号： C07K5/0821 , A61K38/00 , C07K5/0202 , C07K5/021 , C07K5/06034 , C07K5/06113 , C07K5/0806 , C07K5/0808 , C07K5/0815 , C07K5/0819 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1024 , C07K14/78 , Y10S514/825 , Y10S514/826 , Y10S514/863 , Y10S514/866 , Y10S514/885 , Y10S514/903 , Y10S530/868
摘要： The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.
摘要翻译： 本发明涉及可用于抑制和预防细胞粘附和细胞粘附介导的病理学的新型化合物。 本发明还涉及包含这些化合物的药物制剂及其用于抑制和预防细胞粘附和细胞粘附介导的病理学的方法。 本发明的化合物和药物组合物可用作治疗剂或预防剂。 它们特别适用于治疗许多炎性和自身免疫性疾病。
-
公开(公告)号：US08685383B2
公开(公告)日：2014-04-01
申请号：US13493899
申请日：2012-06-11
申请人： Aleksandr Yurkovetskiy , Mao Yin , Timothy B. Lowinger , Joshua D. Thomas , Charles E. Hammond , Cheri A. Stevenson , Natalya D. Bodyak , Patrick R. Conlon , Dmitry R. Gumerov
发明人： Aleksandr Yurkovetskiy , Mao Yin , Timothy B. Lowinger , Joshua D. Thomas , Charles E. Hammond , Cheri A. Stevenson , Natalya D. Bodyak , Patrick R. Conlon , Dmitry R. Gumerov
IPC分类号： A61K31/74 , A61K47/48 , A61K38/04 , C08G63/48 , C08G63/91 , C08G65/32 , C08L67/00 , C08G65/333 , C08G65/334
CPC分类号： A61K47/59 , A61K31/4745 , A61K47/64 , A61K47/6803 , A61K47/6849 , A61K47/6883 , C07K7/02 , C07K16/32 , C08G65/33396 , C08G65/334
摘要： A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -LD-D, the protein based recognition-molecule being connected to the polymeric carrier by LP. Each occurrence of D is independently a therapeutic agent having a molecular weight ≦5 kDa. LD and LP are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.
-
9.发明授权Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof 失效用于递送多核苷酸的改性聚合物，其制备方法及其使用方法公开(公告)号：US08349308B2
公开(公告)日：2013-01-08
申请号：US13073815
申请日：2011-03-28
申请人： Aleksandr Yurkovetskiy , Mao Yin , Timothy B. Lowinger , Carolina B. Cabral , Charles E. Hammond , Cheri A. Stevenson
发明人： Aleksandr Yurkovetskiy , Mao Yin , Timothy B. Lowinger , Carolina B. Cabral , Charles E. Hammond , Cheri A. Stevenson
CPC分类号： C08L59/00 , A61K47/59 , A61K48/0041 , C12N15/111 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12N2320/32
摘要： A polynucleotide delivery vehicle comprising a modified polymer is provided herein, the modified polymer having the following formula: in which W1, W2, W3, W4, W5, W6, Z1, Z2, Z3, Z4, Z5, Z9, R1, R2, R3, R4, R5, n1, n2, n3, n4, n5, and n6 are defined herein. Also disclosed are methods of delivering a polynucleotide to the cytoplasm of a selected tissue type or cell type and methods of reducing expression of a gene in a cell or a subject in need thereof with the modified polymer.
摘要翻译： 本文提供了包含改性聚合物的多核苷酸递送载体，所述改性聚合物具有下式：其中W1，W2，W3，W4，W5，W6，Z1，Z2，Z3，Z4，Z5，Z9，R1，R2， R3，R4，R5，n1，n2，n3，n4，n5和n6在本文中定义。 还公开了将多核苷酸递送至所选组织类型或细胞类型的细胞质的方法以及在有需要的细胞或受试者中用改性聚合物降低基因表达的方法。
-
公开(公告)号：US20100305149A1
公开(公告)日：2010-12-02
申请号：US12789047
申请日：2010-05-27
申请人： Aleksandr Yurkovetskiy , Mao Yin , Gui Liu , Laura C. Akullian , John J. Kane , Cheri A. Stevenson , Charles E. Hammond , Russell C. Petter , John H. Van Duzer , Timothy B. Lowinger
发明人： Aleksandr Yurkovetskiy , Mao Yin , Gui Liu , Laura C. Akullian , John J. Kane , Cheri A. Stevenson , Charles E. Hammond , Russell C. Petter , John H. Van Duzer , Timothy B. Lowinger
IPC分类号： A61K31/439 , A61P35/00 , A61P35/04 , C07D487/18 , C07D491/22 , G01N33/50
CPC分类号： C07D519/04 , A61K47/59 , C07D491/22 , G01N2500/00 , Y10T436/145555
摘要： Polyal-Drug conjugates comprising a variable rate-releasing linker are described along with methods of making such conjugates. Uses for such Polyal-Drug conjugates is also described.
摘要翻译： 描述包含可变速率释放连接体的多价 - 药物共轭物以及制备这种缀合物的方法。 也描述了这种多种药物共轭物的用途。
-
-
-
-
-
-
-
-
-
搜索结果
19 条记录 (耗时 0.032 秒)
