公开(公告)号：US20210130306A1

公开(公告)日：2021-05-06

申请号：US16757096

申请日：2018-10-19

申请人： Laurence RAHME ,  Francois LEPINE ,  Damien MAURA ,  Carmela NAPOLITANO ,  Antonio FELICI ,  Michele NEGRI ,  Stefano FONTANA ,  Daniele ANDREOTTI ,  THE GENERAL HOSPITAL CORPORATION ,  APTUIT (VERONA) SRL, AN EVOTEC COMPANY

发明人： Laurence Rahme ,  Francois Lepine ,  Damien Maura ,  Carmela Napolitano ,  Antonio Felici ,  Michele Negri ,  Stefano Fontana ,  Daniele Andreotti

IPC分类号： C07D263/58 ,  C07C327/42 ,  C07D209/08 ,  C07C255/60 ,  C07C237/42

摘要： The present application provides malonamide compounds, and derivatives thereof (e.g., N-aryl malonamides (NAM), acetamides, oxalamides, and the like), that are useful, for example, for the treatment of acute, chronic/persistent, and/or relapsing infections. Pharmaceutical compositions, methods of treating diseases (e.g., bacterial infections), and methods of reducing bacterial virulence are also provided.

公开(公告)号：US11731946B2

公开(公告)日：2023-08-22

申请号：US16757096

申请日：2018-10-19

申请人： Francois Lepine ,  The General Hospital Corporation ,  Aptuit (Verona) SRL, An Evotec Company

发明人： Laurence Rahme ,  Francois Lepine ,  Damien Maura ,  Carmela Napolitano ,  Antonio Felici ,  Michele Negri ,  Stefano Fontana ,  Daniele Andreotti

IPC分类号： C07D263/58 ,  C07C237/42 ,  C07C255/60 ,  C07C327/42 ,  C07D209/08

CPC分类号： C07D263/58 ,  C07C237/42 ,  C07C255/60 ,  C07C327/42 ,  C07D209/08

摘要： The present application provides malonamide compounds, and derivatives thereof (e.g., N-aryl malonamides (NAM), acetamides, oxalamides, and the like), that are useful, for example, for the treatment of acute, chronic/persistent, and/or relapsing infections. Pharmaceutical compositions, methods of treating diseases (e.g., bacterial infections), and methods of reducing bacterial virulence are also provided.