公开(公告)号：US07618392B2

公开(公告)日：2009-11-17

申请号：US11457330

申请日：2006-07-13

申请人： Leo Martis ,  Mehul Patel ,  Joseph A. Giertych ,  James W. Mongoven ,  Jacqueline A. Kunzler ,  William F. Owen, Jr.

发明人： Leo Martis ,  Mehul Patel ,  Joseph A. Giertych ,  James W. Mongoven ,  Jacqueline A. Kunzler ,  William F. Owen, Jr.

IPC分类号： C12Q1/00

CPC分类号： A61K31/716 ,  C12Q1/04 ,  G01N2333/4722 ,  Y10S436/815

摘要： Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions are provided. The methods and compositions employ modified bioburden testing and the detection of peptidoglycan. A novel cause of aseptic peritonitis is provided—aseptic peritonitis associated with gram positive microbial contamination of a dialysis solution. Peptidoglycan is a major component of a gram positive bacterial cell wall and thus can serve as a marker for gram positive bacteria. In this regard, testing for peptidoglycans can be utilized to effectively prevent peritonitis in patients that use the peritoneal dialysis solutions, such as peritoneal dialysis solutions that contain a glucose polymer including an icodextrin and the like.

摘要翻译： 提供了用于检测腹膜透析溶液中微生物污染物的方法和组合物。 方法和组合物采用修饰的生物负载测试和肽聚糖的检测。 提供无菌性腹膜炎的新原因 - 与透析溶液的革兰氏阳性微生物污染相关的无菌性腹膜炎。 肽聚糖是革兰氏阳性细菌细胞壁的主要成分，因此可以作为革兰氏阳性菌的标记物。 在这方面，可以利用肽聚糖的测试来有效地预防使用腹膜透析溶液的患者腹膜炎，例如含有包含icodextrin等的葡萄糖聚合物的腹膜透析溶液。

公开(公告)号：US20100056990A1

公开(公告)日：2010-03-04

申请号：US12618442

申请日：2009-11-13

申请人： Leo Martis ,  Mehul Patel ,  Joseph A. Giertych ,  James W. Mongoven ,  Jacqueline A. Kunzler ,  William F. Owen, Jr.

发明人： Leo Martis ,  Mehul Patel ,  Joseph A. Giertych ,  James W. Mongoven ,  Jacqueline A. Kunzler ,  William F. Owen, Jr.

IPC分类号： A61M1/28 ,  C12Q1/54

CPC分类号： A61K31/716 ,  C12Q1/04 ,  G01N2333/4722 ,  Y10S436/815

摘要： Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions are provided. The methods and compositions employ modified bioburden testing and the detection of peptidoglycan. A novel cause of aseptic peritonitis is provided—aseptic peritonitis associated with gram positive microbial contamination of a dialysis solution. Peptidoglycan is a major component of a gram positive bacterial cell wall and thus can serve as a marker for gram positive bacteria. In this regard, testing for peptidoglycans can be utilized to effectively prevent peritonitis in patients that use the peritoneal dialysis solutions, such as peritoneal dialysis solutions that contain a glucose polymer including an icodextrin and the like.

摘要翻译： 提供了用于检测腹膜透析溶液中微生物污染物的方法和组合物。 方法和组合物采用修饰的生物负载测试和肽聚糖的检测。 提供无菌性腹膜炎的新原因 - 与透析溶液的革兰氏阳性微生物污染相关的无菌性腹膜炎。 肽聚糖是革兰氏阳性细菌细胞壁的主要成分，因此可以作为革兰氏阳性菌的标记物。 在这方面，可以利用肽聚糖的测试来有效地预防使用腹膜透析溶液的患者腹膜炎，例如含有包含icodextrin等的葡萄糖聚合物的腹膜透析溶液。

公开(公告)号：US07118857B2

公开(公告)日：2006-10-10

申请号：US10789320

申请日：2004-02-27

申请人： Leo Martis ,  Mehul Patel ,  Joseph A. Giertych ,  James W. Mongoven ,  Jacqueline A. Kunzler ,  William F. Owen, Jr.

发明人： Leo Martis ,  Mehul Patel ,  Joseph A. Giertych ,  James W. Mongoven ,  Jacqueline A. Kunzler ,  William F. Owen, Jr.

IPC分类号： C12Q1/00

CPC分类号： A61K31/716 ,  C12Q1/04 ,  G01N2333/4722 ,  Y10S436/815

摘要： Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions are provided. The methods and compositions employ modified bioburden testing and the detection of peptidoglycan. A novel cause of aseptic peritonitis is provided—aseptic peritonitis associated with gram positive microbial contamination of a dialysis solution. Peptidoglycan is a major component of a gram positive bacterial cell wall and thus can serve as a marker for gram positive bacteria. In this regard, testing for peptidoglycans can be utilized to effectively prevent peritonitis in patients that use the peritoneal dialysis solutions, such as peritoneal dialysis solutions that contain a glucose polymer including an icodextrin and the like.

公开(公告)号：US08546097B2

公开(公告)日：2013-10-01

申请号：US12618442

申请日：2009-11-13

申请人： Leo Martis ,  Mehul Patel ,  Joseph A. Giertych ,  James W. Mongoven ,  Jacqueline A. Kunzler ,  William F. Owen, Jr.

发明人： Leo Martis ,  Mehul Patel ,  Joseph A. Giertych ,  James W. Mongoven ,  Jacqueline A. Kunzler ,  William F. Owen, Jr.

IPC分类号： C12G1/00

CPC分类号： A61K31/716 ,  C12Q1/04 ,  G01N2333/4722 ,  Y10S436/815

摘要： Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions are provided. The methods and compositions employ modified bioburden testing and the detection of peptidoglycan. A novel cause of aseptic peritonitis is provided—aseptic peritonitis associated with gram positive microbial contamination of a dialysis solution. Peptidoglycan is a major component of a gram positive bacterial cell wall and thus can serve as a marker for gram positive bacteria. In this regard, testing for peptidoglycans can be utilized to effectively prevent peritonitis in patients that use the peritoneal dialysis solutions, such as peritoneal dialysis solutions that contain a glucose polymer including an icodextrin and the like.

摘要翻译： 提供了用于检测腹膜透析溶液中微生物污染物的方法和组合物。 方法和组合物采用修饰的生物负载测试和肽聚糖的检测。 提供无菌性腹膜炎的新原因 - 与透析溶液的革兰氏阳性微生物污染相关的无菌性腹膜炎。 肽聚糖是革兰氏阳性细菌细胞壁的主要成分，因此可以作为革兰氏阳性菌的标记物。 在这方面，可以利用肽聚糖的测试来有效地预防使用腹膜透析溶液的患者腹膜炎，例如含有包含icodextrin等的葡萄糖聚合物的腹膜透析溶液。