公开(公告)号：US20240230676A1

公开(公告)日：2024-07-11

申请号：US18558150

申请日：2022-04-29

申请人： Roche Diagnostics Operations, Inc.

发明人： Felix Gruenewald ,  Victor Johann Raul Jeger ,  Martin Klammer ,  Philipp Schuetz ,  Maria von Holtey ,  Stephen Weber ,  Heike Wegmeyer ,  Ursula-Henrike Wienhues-Thelen

IPC分类号： G01N33/68 ,  C12Q1/37 ,  C12Q1/52 ,  G01N33/72 ,  G16H50/20

CPC分类号： G01N33/6893 ,  C12Q1/37 ,  C12Q1/52 ,  G01N33/728 ,  G16H50/20 ,  G01N2333/4722 ,  G01N2333/8139 ,  G01N2333/91188 ,  G01N2800/26 ,  G01N2800/50

摘要： The present invention concerns the field of diagnostics. Specifically, it relates to a method for assessing a subject with suspected infection comprising the steps of determining the amount of a first biomarker in a sample of the subject, said first biomarker being ESM-1, determining the amount of a second biomarker in a sample of the subject, wherein said second biomarker is Creatinine or a Cystatin C, comparing the amounts of the biomarkers to references for said biomarkers and/or calculating a score for assessing the subject with suspected infection based on the amounts of the biomarkers, and assessing said subject based on the comparison and/or the calculation. The invention also relates to the use of a first biomarker being ESM-1 and a second biomarker being Creatinine or a Cystatin C or a detection agent specifically binding to said first biomarker and a detection agent specifically binding to said second biomarker for assessing a subject with suspected infection. Moreover, the invention further relates to a computer-implemented method for assessing a subject with suspected infection and a device and a kit for assessing a subject with suspected infection.

公开(公告)号：US20240192227A1

公开(公告)日：2024-06-13

申请号：US18482419

申请日：2023-10-06

申请人： Joslin Diabetes Center, Inc.

发明人： Andrzej Krolewski

IPC分类号： G01N33/68 ,  A61K38/18 ,  A61K38/19 ,  G16H20/10 ,  G16H50/30

CPC分类号： G01N33/6893 ,  A61K38/1825 ,  A61K38/191 ,  G01N33/6848 ,  G16H20/10 ,  G16H50/30 ,  G01N2333/4709 ,  G01N2333/4722 ,  G01N2333/50 ,  G01N2333/525 ,  G01N2800/347 ,  G01N2800/50

摘要： The present disclosure provides methods for identifying a human subject at risk of developing progressive renal decline by examining a level(s) of a protective protein(s) in a sample from the subject. Level(s) of protein(s) identified in the disclosure are associated with protection against progressive renal failure and end-stage kidney disease (ESKD). Examples of such protective proteins include FGF20, ANGPT1, and TNFSF12.

公开(公告)号：US20240094210A1

公开(公告)日：2024-03-21

申请号：US18261207

申请日：2022-01-17

申请人： FUJIREBIO INC.

发明人： Tomonori NISHII ,  Eriko SATO ,  Kumiko IIDA ,  Shintaro YAGI ,  Katsumi AOYAGI

IPC分类号： G01N33/574

CPC分类号： G01N33/57438 ,  G01N2333/4722 ,  G01N2470/04

摘要： A method for treating a specimen in soluble GPC3 immunoassay, the method including mixing a soluble GPC3-containing specimen with a reducing agent. A soluble GPC3 immunoassay method including the following (a) and (b): (a) mixing a soluble GPC3-containing specimen with a reducing agent; and (b) measuring the amount of soluble GPC3 in the mixture obtained in (a) using one or more kinds of antibodies against soluble GPC3. A soluble GPC3 immunoassay reagent including the following (a) and (b): (a) a reducing agent; and (b) one or more kinds of antibodies against soluble GPC3.

公开(公告)号：US09857355B2

公开(公告)日：2018-01-02

申请号：US14779353

申请日：2014-03-25

申请人： ROQUETTE FRERES

发明人： Pierre Lanos ,  Marc Biguet ,  Roselyne Bernard ,  Fabrice Allain ,  Mathieu Carpentier ,  Agnès Denys ,  Héla Hacine-Gherbi

IPC分类号： G01N33/50

CPC分类号： G01N33/5005 ,  G01N2333/4722 ,  G01N2333/70596 ,  G01N2400/38 ,  G01N2400/40

摘要： The present invention relates to a biological method for assaying peptidoglycans (PGN) in a sample, particularly a sample of glucose polymers. The PGN assay includes: a) treating the glucose polymer sample by sonication, heating, and/or alkalizing; b) placing the treated sample or a dilution thereof in contact with a recombinant cell expressing an exogenous TLR2 (toll-like receptor 2) and a reporter gene directly dependent on the signaling pathway associated with the TLR2. The reporter gene codes for a colored or fluorescent protein or for a protein the activity of which is measurable with or without a substrate; c) measuring the reporter gene signal; and d) determining the amount of PGN in the sample using a standard curve of the correlation between the amount or PGN and the strength of the reporter gene signal.

公开(公告)号：US20170322227A1

公开(公告)日：2017-11-09

申请号：US15611025

申请日：2017-06-01

申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION

发明人： Gordon W. LAURIE

IPC分类号： G01N33/68 ,  G01N33/573 ,  A61K9/00 ,  A61K38/17

CPC分类号： G01N33/6893 ,  A61K9/0048 ,  A61K38/1709 ,  A61K38/18 ,  C07K14/475 ,  C12Y302/01166 ,  G01N33/573 ,  G01N33/68 ,  G01N2333/4706 ,  G01N2333/4722 ,  G01N2333/4728 ,  G01N2333/70596 ,  G01N2333/924 ,  G01N2800/16 ,  G01N2800/162

摘要： The present invention provides compositions and methods for identifying subjects suffering from dry eye that can be treated by topical administration of a composition comprising lacritin or a bioactive fragment thereof. The application discloses in part that a ˜90 KDa deglycanated form of syndecan-1 is abundant in tears of normal individuals but not individuals suffering from dry eye, whereas a ˜25 kDa syndecan-1 fragment is detectable in dry, but not normal tears.

公开(公告)号：US20170176457A1

公开(公告)日：2017-06-22

申请号：US15125357

申请日：2015-03-11

申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION

发明人： Gordon W. LAURIE

IPC分类号： G01N33/68 ,  A61K9/00 ,  G01N33/573 ,  A61K38/17

CPC分类号： G01N33/6893 ,  A61K9/0048 ,  A61K38/1709 ,  A61K38/18 ,  C07K14/475 ,  C12Y302/01166 ,  G01N33/573 ,  G01N33/68 ,  G01N2333/4706 ,  G01N2333/4722 ,  G01N2333/4728 ,  G01N2333/70596 ,  G01N2333/924 ,  G01N2800/16 ,  G01N2800/162

摘要： The present invention provides compositions and methods for identifying subjects suffering from dry eye that can be treated by topical administration of a composition comprising lacritin or a bioactive fragment thereof. The application discloses in part that a ˜90 KDa deglycanated form of syndecan-1 is abundant in tears of normal individuals but not individuals suffering from dry eye, whereas a ˜25 kDa syndecan-1 fragment is detectable in dry, but no normal tears.

公开(公告)号：US20160222430A1

公开(公告)日：2016-08-04

申请号：US15021599

申请日：2014-09-11

申请人： INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

发明人： Michael S. Van Nieuwenhze ,  Yves V. Brun ,  Erkin Kuru

IPC分类号： C12Q1/02 ,  C07K5/083 ,  C07K5/103 ,  G01N33/58 ,  C12Q1/10 ,  C12Q1/14 ,  C12Q1/04 ,  C07K5/062 ,  C07K7/06

CPC分类号： C12Q1/02 ,  C07K5/06026 ,  C07K5/0806 ,  C07K5/1008 ,  C07K7/06 ,  C07K14/4725 ,  C12Q1/025 ,  C12Q1/04 ,  C12Q1/10 ,  C12Q1/14 ,  G01N33/5035 ,  G01N33/56911 ,  G01N33/582 ,  G01N2333/245 ,  G01N2333/3156 ,  G01N2333/32 ,  G01N2333/4722 ,  G01N2500/10

摘要： Disclosed herein are compositions for assessing peptidoglycan biosynthesis in bacteria using modified dipeptides containing a bioorthogonal tag and applying novel post-labeling methods to label the bioorthogonal tag. The resultant, labeled peptidoglycan structures are amenable for identifying bacteria by microscopic visualization.

摘要翻译： 本文公开了用于使用包含生物正交标记的修饰的二肽评估细菌中肽聚糖生物合成的组合物，并应用新的后标记方法来标记生物正交标记。 所得到的标记的肽聚糖结构可用于通过显微镜可视化鉴定细菌。

公开(公告)号：US20160017049A1

公开(公告)日：2016-01-21

申请号：US14718932

申请日：2015-05-21

申请人： GENENTECH, INC.

发明人： Paul Polakis ,  Youjun Chen

IPC分类号： C07K16/30 ,  C07K16/28 ,  A61K51/10 ,  A61K47/48 ,  A61K39/395

CPC分类号： C07K16/303 ,  A61K39/39558 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6859 ,  A61K47/6889 ,  A61K51/1057 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/77 ,  G01N2333/4722

摘要： The invention provides anti-GPC3 antibodies and immunoconjugates and methods of using the same.

摘要翻译： 本发明提供抗GPC3抗体和免疫缀合物及其使用方法。

公开(公告)号：US20150031057A1

公开(公告)日：2015-01-29

申请号：US14379887

申请日：2013-02-22

申请人： NEUROTUNE AG

发明人： Stefan Hettwer ,  Jan Willem Vrijbloed ,  Dominik Stuebl ,  Marcel Roos

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N33/68 ,  G01N2333/4722 ,  G01N2333/96433 ,  G01N2800/347

摘要： Method for the determination of the renal function wherein the amount of at least one agrin fragment derived by neurotrypsin cleavage of agrin is measured in a sample taken from a patient and the measured amount of the agrin-fragment in the sample is used as indicator for renal function.

摘要翻译： 用于测定肾功能的方法，其中在取自患者的样品中测量由集聚蛋白的神经胰蛋白酶切割得到的至少一种集聚蛋白片段的量，并将样品中集聚蛋白片段的测定量用作肾脏的指标 功能。

公开(公告)号：US08841079B2

公开(公告)日：2014-09-23

申请号：US13682454

申请日：2012-11-20

申请人： Cytonics Corporation

发明人： Gaetano J. Scuderi ,  Lewis S. Hanna ,  Robert Bowser

IPC分类号： G01N33/53 ,  G01N33/68 ,  G01N33/543

CPC分类号： G01N33/68 ,  G01N33/6887 ,  G01N2333/4722 ,  G01N2333/78 ,  G01N2800/102 ,  G01N2800/52

摘要： Biomarkers, including isolated fibronectin-aggrecan complexes that correlate with spinal or joint pain and inflammation, and methods for their detection are provided. Also provided are methods for identifying treatment sites in the spine or joint for treatment of pain and inflammation by detecting the presence of, or increased levels of, fibronectin-aggrecan complexes. Methods for treating spinal or joint pain and inflammation are also provided.

摘要翻译： 提供了生物标志物，包括与脊髓或关节疼痛和炎症相关的分离的纤连蛋白 - 聚集蛋白聚糖复合物，以及用于其检测的方法。 还提供了用于通过检测纤连蛋白 - 聚集蛋白聚糖复合物的存在或增加水平来鉴定脊柱或关节中用于治疗疼痛和炎症的治疗部位的方法。 还提供了治疗脊髓或关节疼痛和炎症的方法。