公开(公告)号：US20080311192A1

公开(公告)日：2008-12-18

申请号：US11761843

申请日：2007-06-12

申请人： Leslie George West ,  Nicole Lee Windsor ,  Anilkumar Ganapati Gaonkar ,  Nathan V. Matusheski ,  Nam-Cheol Kim ,  Cathy Jean Ludwig ,  Leslie Lewis Lawrence

发明人： Leslie George West ,  Nicole Lee Windsor ,  Anilkumar Ganapati Gaonkar ,  Nathan V. Matusheski ,  Nam-Cheol Kim ,  Cathy Jean Ludwig ,  Leslie Lewis Lawrence

IPC分类号： A61K9/14 ,  A61K38/47 ,  A61K9/48

CPC分类号： A61K9/1652 ,  A61K9/5063 ,  A61K31/375 ,  A61K31/7028 ,  A61K38/47 ,  A61K2300/00

摘要： The present invention relates to a particulate composition comprising enteric-coated glucosinolate and beta-thioglucosidase particles. The present invention further provides a method of converting glucosinolate to isothiocyanate in the small intestine comprising orally administering to a subject an enteric-coated chemoprotectant precursor composition comprising enteric-coated glucosinolate and beta-thioglucosinodase particles. In another aspect, uncoated glucosinolate and beta-thioglucosinodase particles may be provided in an enteric-coated capsule. Preferably, the glucosinolate is glucoraphanin and the beta-thioglucosidase is myrosinase. The enteric coating targets the compound for release in the small intestine where beta-thioglucosinodase enzyme converts glucosinolate to chemoprotectant isothiocyanate.

摘要翻译： 本发明涉及包含肠溶包衣的硫代葡萄糖苷苷和β-硫代葡糖苷酶颗粒的颗粒组合物。 本发明还提供了一种在小肠中将芥子油苷转化成异硫氰酸酯的方法，其包括向受试者口服施用包含肠溶包衣的硫代葡萄糖苷和β-硫代葡萄糖苷糖苷酶颗粒的肠溶衣化学保护剂前体组合物。 在另一方面，可以在肠溶衣胶囊中提供未包衣的硫代葡萄糖苷和β-硫代葡糖苷调节酶颗粒。 优选地，硫代葡萄糖苷是葡萄糖甙元，β-硫代葡萄糖苷酶是黑芥子酶。 肠溶衣靶向化合物在小肠中释放，其中β-硫代葡糖苷异酶将芥子油苷转化成化学保护剂异硫氰酸酯。