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1.发明申请Method for preparing 13 5-triaminobenzene and hydrolyzing it into high-purity phloroglucinal 有权制备13 5-三氨基苯并将其水解成高纯度离体液体的方法公开(公告)号：US20050165256A1
公开(公告)日：2005-07-28
申请号：US10517716
申请日：2003-06-06
IPC分类号： A61P21/02 , A61K31/05 , A61P21/00 , A61P25/04 , A61P25/08 , C07B61/00 , C07C29/10 , C07C37/05 , C07C37/72 , C07C37/82 , C07C37/84 , C07C39/10 , C07C209/10 , C07C211/49 , C07C211/50 , C07D209/10
CPC分类号： C07C209/10 , C07C37/05 , C07C39/10
摘要： The invention concerns a method for method for preparing 1,3,5-triaminobenzene, characterized in that it comprises a step which consists in amination of a compound of formula (I), wherein: A represents a halogen atom or a NH2 group; X1 and X2, identical or different, represent each a halogen atom, the amination step being carried out in the presence of ammonia and a catalyst selected from the group consisting of copper salts, cupric and cuprous oxides or mixtures thereof at a temperature ranging between 150° C. and 250° C. and at a pressure higher that 35 bars.
摘要翻译： 本发明涉及一种制备1,3,5-三氨基苯的方法，其特征在于它包括一个步骤，该步骤由式（I）化合物胺化而成，其中：A代表卤原子或NH 2 组; X 1和X 2相同或不同，表示各自的卤素原子，胺化步骤在氨存在下进行，并且催化剂选自： 铜盐，铜和氧化亚铜或其混合物，温度范围为150℃至250℃，压力高于35巴。
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2.发明授权Method for preparing 1,3,5-triaminobenzene and hydrolyzing it into high-purity phloroglucinal 有权制备1,3,5-三氨基苯并将其水解成高纯度离体液体的方法公开(公告)号：US07217840B2
公开(公告)日：2007-05-15
申请号：US10517716
申请日：2003-06-06
IPC分类号： C07C209/10 , C07C37/05
CPC分类号： C07C209/10 , C07C37/05 , C07C39/10
摘要： The invention concerns a method for method for preparing 1,3,5-triaminobenzene, characterized in that it comprises a step which consists in amination of a compound of formula (I), wherein: A represents a halogen atom or a NH2 group; X1 and X2, identical or different, represent each a halogen atom, the amination step being carried out in the presence of ammonia and a catalyst selected from the group consisting of copper salts, cupric and cuprous oxides or mixtures thereof at a temperature ranging between 150° C. and 250° C. and at a pressure higher that 35 bars
摘要翻译： 本发明涉及一种制备1,3,5-三氨基苯的方法，其特征在于它包括一个步骤，该步骤由式（I）化合物胺化而成，其中：A代表卤原子或NH 2 组; X 1和X 2相同或不同，表示各自的卤素原子，胺化步骤在氨存在下进行，并且催化剂选自： 铜盐，铜和氧化亚铜或其混合物，温度范围为150℃至250℃，压力高于35巴
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公开(公告)号：US20150266845A1
公开(公告)日：2015-09-24
申请号：US14660514
申请日：2015-03-17
IPC分类号： C07D311/16 , C07D493/04
CPC分类号： C07D311/16 , C07D493/04
摘要： Methods for the synthesis of psoralen derivatives are provided. In one embodiment, the method may include acetylating a compound of formula (II) to form a compound of formula (III), subjecting the compound of formula (III) to a Fries rearrangement to form a compound of formula (IV), and subjecting the compound of formula (IV) to cyclization, reduction and aromatization, to form a compound having the following formula (I):
摘要翻译： 提供了补骨脂素衍生物的合成方法。 在一个实施方案中，该方法可以包括将式（II）化合物乙酰化以形成式（III）化合物，使式（III）化合物进行弗里斯重排以形成式（IV）化合物， 式（Ⅳ）化合物进行环化，还原和芳构化，形成具有下式（I）的化合物：
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