公开(公告)号：US20220136060A1

公开(公告)日：2022-05-05

申请号：US17367220

申请日：2021-07-02

申请人： Li Chen ,  Yu Zhou ,  RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL

发明人： Li Chen ,  Yu Zhou ,  David Brigstock ,  Gail Besner

IPC分类号： C12Q1/6886 ,  A61K33/243 ,  A61K31/713

摘要： The present invention provides novel methods and kits for determining whether a subject is suffering from cisplatin-containing resistant ovarian and methods for treating and reversing resistance.

公开(公告)号：US20220010384A1

公开(公告)日：2022-01-13

申请号：US17378408

申请日：2021-07-16

申请人： Li Chen ,  Yu Zhou ,  RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL

发明人： Li Chen ,  Yu Zhou ,  David Brigstock ,  Gail Besner

IPC分类号： C12Q1/6886

摘要： This disclosure provides methods for determining whether a subject is suffering from a liver cancer, such as hepatic carcinoma, comprising determining the expression level of miRNA-33b and/or miRNA46-a, in a sample of exosomes enriched from a body fluid of the subject, wherein low expression of the miRNA-33b and/or miRNA-46a as compared to a control is indicative of the subject suffering from a liver cancer, e.g., hepatic carcinoma. The subject may also be suffering from a fibrotic disease, liver fibrosis, and/or is or was infected with hepatitis B.

公开(公告)号：US20220011312A1

公开(公告)日：2022-01-13

申请号：US17379878

申请日：2021-07-19

申请人： Li Chen ,  Yu Zhou ,  RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL

发明人： Li Chen ,  Yu Zhou ,  David Brigstock ,  Gail Besner

IPC分类号： G01N33/574 ,  A61K45/06 ,  C12Q1/6886

摘要： The present disclosure provides a novel method for monitoring the conversion of oral precancerous lesions to oral cancers, including monitoring changes in oral exosome concentrations in a subject, thereby determining the state of the disease and the risk of carcinogenesis. The disclosure also relates to a detection kit for use in the above method.

公开(公告)号：US20220162700A1

公开(公告)日：2022-05-26

申请号：US17367201

申请日：2021-07-02

申请人： Li Chen ,  Yu Chou ,  RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL

发明人： Li Chen ,  Yu Zhou ,  David Brigstock ,  Gail Besner

IPC分类号： C12Q1/6883 ,  C12N15/113 ,  C12N15/10

摘要： The present invention provides novel methods and kits for determining whether a subject is suffering from endometriosis or an associated disorder. It also provides methods and kits for determining whether a subject suffering from endometriosis or an associated disorder is more or less likely to be responsive to a therapy to treat endometriosis or an associated disorder.

公开(公告)号：US11254938B2

公开(公告)日：2022-02-22

申请号：US16794066

申请日：2020-02-18

申请人： Research Institute at Nationwide Children's Hospital

发明人： David Brigstock ,  Li Chen

IPC分类号： C12N15/113 ,  C12Q1/6883 ,  C12Q1/68 ,  C12N15/11 ,  A61K31/00 ,  A61K9/19 ,  A61K31/7088 ,  A61K45/06

摘要： This disclosure provides pharmaceutical compositions and purified or isolated naturally occurring exosome products that have therapeutic use for treating an unmet medical need. The exosome compositions contain an effective amount of exosomes isolated from a body fluid of a non-diseased subject. The compositions are useful in the treatment of a variety of fibrotic diseases.

公开(公告)号：US11180810B2

公开(公告)日：2021-11-23

申请号：US15764284

申请日：2016-09-28

申请人： RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL ,  BEIJING FRIENDSHIP HOSPITAL, CAPITAL MEDICAL UNIVERSITY

发明人： David Brigstock ,  Li Chen ,  Hong You ,  Min Cong

IPC分类号： C12Q1/6883

摘要： This disclosure provides kits and methods for determining whether a subject is suffering from a liver disease, and/or whether the subject will be a responsive to a therapy for a liver disease. The disclosed methods comprise determining the miR profile of exosomes isolated from a body fluid of the subject.

公开(公告)号：US20200263178A1

公开(公告)日：2020-08-20

申请号：US16794066

申请日：2020-02-18

申请人： Research Institute at Nationwide Children's Hospital

发明人： David Brigstock ,  Li Chen

IPC分类号： C12N15/113 ,  A61K31/00 ,  C12Q1/68 ,  C12N15/11 ,  C12Q1/6883 ,  A61K45/06 ,  A61K31/7088 ,  A61K9/19

摘要： This disclosure provides pharmaceutical compositions and purified or isolated naturally occurring exosome products that have therapeutic use for treating an unmet medical need. The exosome compositions contain an effective amount of exosomes isolated from a body fluid of a non-diseased subject. The compositions are useful in the treatment of a variety of fibrotic diseases.

公开(公告)号：US20180282810A1

公开(公告)日：2018-10-04

申请号：US15764284

申请日：2016-09-28

申请人： RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL ,  BEIJING FRIENDSHIP HOSPITAL, CAPITAL MEDICAL UNIVERSITY

发明人： David Brigstock ,  Li Chen ,  Hong You ,  Min Cong

IPC分类号： C12Q1/6883

摘要： This disclosure provides kits and methods for determining whether a subject is suffering from a liver disease, and/or whether the subject will be a responsive to a therapy for a liver disease. The disclosed methods comprise determining the miR profile of exosomes isolated from a body fluid of the subject.

公开(公告)号：US20170298352A1

公开(公告)日：2017-10-19

申请号：US15515570

申请日：2015-09-29

申请人： Research Institute at Nationwide Children's Hospital

发明人： David Brigstock ,  Li Chen

IPC分类号： C12N15/113 ,  A61K45/06 ,  A61K9/19 ,  A61K31/7088

CPC分类号： C12N15/113 ,  A61K9/19 ,  A61K31/00 ,  A61K31/7088 ,  A61K45/06 ,  C12N15/11 ,  C12N2310/141 ,  C12N2310/20 ,  C12N2320/32 ,  C12N2330/10 ,  C12Q1/68 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/178 ,  G01N2800/52 ,  G01N2800/7052

摘要： This disclosure provides pharmaceutical compositions and purified or isolated naturally occurring exosome products that have therapeutic use for treating an unmet medical need. The exosome compositions contain an effective amount of exosomes isolated from a body fluid of a non-diseased subject. The compositions are useful in the treatment of a variety of fibrotic diseases.