公开(公告)号：US09333215B2

公开(公告)日：2016-05-10

申请号：US13941106

申请日：2013-07-12

Applicant: Li Fu

Inventor： Li Fu ,  Qi Lu

IPC: A61K31/704 ,  A61K9/00 ,  A61K9/08 ,  A61K9/19 ,  A61K47/40 ,  A61K47/48 ,  B82Y5/00

CPC classification number: A61K31/704 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/19 ,  A61K47/40 ,  A61K47/6951 ,  B82Y5/00 ,  Y02P20/582

Abstract: A preparation of a kind of 20(R)-ginsenoside Rg3 medicinal composition aqueous solution containing ginsenoside Rg3 0.5˜10 mg/ml: add 0.1-5% of ginsenoside solution to 0.1˜30% of adjuvant A, B{circle around (1)}{circle around (2)}{circle around (5)} at the temperature of 40˜100° C., the ratio of these two is 1:1˜300, add water after the solvent is recycled under reduced pressure; another kind of 20(R)-ginsenoside Rg3 medicinal composition aqueous solution contains 0.1˜2 mg/ml of 20 (R) of the ginsenoside Rg3, the preparation: add 0.1˜5% of ginsenoside solution to 20˜65% of adjuvant B{circle around (3)}{circle around (4)} at the temperature of 60˜100° C., main material to adjuvant B=1:100˜400, add water after the solvent is recycled under reduced pressure. The above 20 (R) ginsenoside Rg3 composition aqueous solution and the powder after lyophilization can be used to prepare injectable, oral administration and external use, and the bioactivity of these preparations is high, and with the actions of anti cancer, efficacy potentiation and toxicity attenuation effects of the combined chemical or radiation therapy of tumor, enhancement of human immune functions, improvement of human memory, anti fatigue, and detumescence, pain relieving.

Abstract translation: 含有人参皂甙Rg3的20（R） - 人参皂苷Rg3药物组合物水溶液0.5〜10mg / ml的制剂：将0.1〜30％的人参皂甙溶液加入0.1〜30％的佐剂A，B ）} {圆周（2）} {圆周（5）}在40〜100℃的温度下，这两者的比例为1：1〜300，在减压下回收溶剂后加水; 另外一种20（R） - 人参皂甙Rg3药用组合物水溶液含有0.1〜2mg / ml的人参皂甙Rg3，其制备方法：将20〜65％的人参皂甙溶液加入0.1〜5％ {圆周围（3）} {圆周围（4）}，温度为60〜100℃，辅料B = 1：100〜400的主要原料，在减压下回收溶剂后加水。 上述20（R）人参皂苷Rg3组合物水溶液和冻干后的粉末可用于制备注射，口服和外用，并且这些制剂的生物活性高，并具有抗癌作用，功效增强和毒性 肿瘤组合化学或放射治疗的衰减效应，人体免疫功能的增强，人体记忆的改善，抗疲劳和消肿，疼痛缓解。

公开(公告)号：US08487090B2

公开(公告)日：2013-07-16

申请号：US12301996

申请日：2007-05-18

Applicant: Li Fu ,  Qi Lu

Inventor： Li Fu ,  Qi Lu

IPC: C07H15/24 ,  A61K31/704 ,  A61P35/00

CPC classification number: A61K31/704 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/19 ,  A61K47/40 ,  A61K47/6951 ,  B82Y5/00 ,  Y02P20/582

Abstract: A preparation of a kind of 20(R)-ginsenoside Rg3 medicinal composition aqueous solution containing ginsenoside Rg3 0.5˜10 mg/ml: add 0.1-5% of ginsenoside solution to 0.1˜30% of adjuvant A, B{circle around (1)}{circle around (2)}{circle around (5)} at the temperature of 40˜100° C., the ratio of these two is 1:1˜300, add water after the solvent is recycled under reduced pressure; another kind of 20(R)-ginsenoside Rg3 medicinal composition aqueous solution contains 0.1˜2 mg/ml of 20(R) of the ginsenoside Rg3, the preparation: add 0.1˜5% of ginsenoside solution to 20˜65% of adjuvant B{circle around (3)}{circle around (4)} at the temperature of 60˜100° C., main material to adjuvant B=1:100˜400, add water after the solvent is recycled under reduced pressure. The above 20(R) ginsenoside Rg3 composition aqueous solution and the powder after lyophilizaton can be used to prepare injectable, oral administration and external use, and the bioactivity of these preparations is high, and with the actions of anti cancer, efficacy potentiation and toxicity attenuation effects of the combined chemical or radiation therapy of tumor, enhancement of human immune functions, improvement of human memory, anti fatigue, and detumescence, pain relieving.

Abstract translation: 制备一种含有人参皂甙Rg3的20（R） - 人参皂甙Rg3药物组合物水溶液0.5〜10mg / ml：将0.1〜30％人参皂甙溶液加入0.1〜30％的佐剂A，B ）} {圆周（2）}（圆周围（5）}在40〜100℃的温度下，这两者的比例为1：1〜300，溶剂在减压下循环后加水; 另一种20（R） - 人参皂甙Rg3药用组合物水溶液含有0.1〜2mg / ml的20（R）人参皂甙Rg3，制备方法：将20％〜65％的人参皂甙溶液加0.1〜5％ {圆周（3）} {圆周（4）}在60〜100℃的温度下，辅料B = 1：100〜400的主要原料，在减压下回收溶剂后加水。 上述20（R）人参皂苷Rg3组合物水溶液和冻干后的粉末可用于制备注射，口服和外用，并且这些制剂的生物活性高，并具有抗癌作用，功效增强和毒性 肿瘤组合化学或放射治疗的衰减效应，人体免疫功能的增强，人体记忆的改善，抗疲劳和消肿，疼痛缓解。

公开(公告)号：US10238676B2

公开(公告)日：2019-03-26

申请号：US15036494

申请日：2014-11-06

Applicant: Li Fu

Inventor： Li Fu ,  Kaiqian Wang ,  Qiang Fu ,  Zhengxian Liu ,  Qi Lu ,  Xin Gai

IPC: A61K31/704 ,  A61K36/888 ,  A61K36/9066 ,  A61K36/236 ,  A61K36/258 ,  A61K36/42

Abstract: The present invention discloses an application of ginsenoside Rg3 in preparing a medicine or product for preventing and treating dementia, and a preparation method thereof, which belong to the fields of medicines and health care products, and its products comprise a topical preparation, oral preparation and injection of the ginsenoside Rg3; and the Rg3 medicine or formulating prepared Rg3 compound medicine is prepared by using a solubilizer, a transdermal agent, a reagent promoting the absorption by penetrating a blood-brain barrier and an extractive, achieving the effect that the medicine penetrates the blood-brain barrier, and is used for preventing and treating dementia.

公开(公告)号：US20120149656A1

公开(公告)日：2012-06-14

申请号：US12301996

申请日：2007-05-18

Applicant: Li Fu ,  Hong Liu ,  Mingming Lu ,  Qi Lu ,  Seong Tae Cho ,  Wanzhe Cui

Inventor： Li Fu ,  Hong Liu ,  Mingming Lu ,  Qi Lu ,  Seong Tae Cho ,  Wanzhe Cui

IPC: A61K31/704 ,  A61P25/00 ,  A61P37/04 ,  A61P29/00 ,  C07J17/00 ,  A61P35/00

CPC classification number: A61K31/704 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/19 ,  A61K47/40 ,  A61K47/6951 ,  B82Y5/00 ,  Y02P20/582

Abstract: A preparation of a kind of 20(R)-ginsenoside Rg3 medicinal composition aqueous solution containing ginsenoside Rg3 0.5˜10 mg/ml: add 0.1-5% of ginsenoside solution to 0.1˜30% of adjuvant A, B{circle around (1)}{circle around (2)}{circle around (5)} at the temperature of 40˜100° C., the ratio of these two is 1:1˜300, add water after the solvent is recycled under reduced pressure; another kind of 20(R)-ginsenoside Rg3 medicinal composition aqueous solution contains 0.1˜2 mg/ml of 20 (R) of the ginsenoside Rg3, the preparation: add 0.1˜5% of ginsenoside solution to 20˜65% of adjuvant B{circle around (3)}{circle around (4)} at the temperature of 60˜100° C., main material to adjuvant B=1:100˜400, add water after the solvent is recycled under reduced pressure. The above 20 (R) ginsenoside Rg3 composition aqueous solution and the powder after lyophilizaton can be used to prepare injectable, oral administration and external use, and the bioactivity of these preparations is high, and with the actions of anti cancer, efficacy potentiation and toxicity attenuation effects of the combined chemical or radiation therapy of tumor, enhancement of human immune functions, improvement of human memory, anti fatigue, and detumescence, pain relieving.

Abstract translation: 含有人参皂甙Rg3的20（R） - 人参皂苷Rg3药物组合物水溶液0.5〜10mg / ml的制剂：将0.1〜30％的人参皂甙溶液加入0.1〜30％的佐剂A，B ）} {圆周（2）} {圆周（5）}在40〜100℃的温度下，这两者的比例为1：1〜300，在减压下回收溶剂后加水; 另外一种20（R） - 人参皂甙Rg3药用组合物水溶液含有0.1〜2mg / ml的人参皂甙Rg3，其制备方法：将20〜65％的人参皂甙溶液加入0.1〜5％ {圆周围（3）} {圆周围（4）}，温度为60〜100℃，辅料B = 1：100〜400的主要原料，在减压下回收溶剂后加水。 上述20（R）人参皂苷Rg3组合物水溶液和冻干后的粉末可用于制备注射，口服和外用，并且这些制剂的生物活性高，并具有抗癌作用，功效增强和毒性 肿瘤组合化学或放射治疗的衰减效应，人体免疫功能的增强，人体记忆的改善，抗疲劳和消肿，疼痛缓解。

公开(公告)号：US20160271154A1

公开(公告)日：2016-09-22

申请号：US15036494

申请日：2014-11-06

Applicant: Li FU

Inventor： Li Fu ,  Kaiqian Wang ,  Qiang Fu ,  Zhengxian Liu ,  Qi Lu ,  Xin Gai

IPC: A61K31/704

CPC classification number: A61K31/704 ,  A61K36/236 ,  A61K36/258 ,  A61K36/42 ,  A61K36/888 ,  A61K36/9066 ,  A61K2300/00

Abstract: The present invention discloses an application of ginsenoside Rg3 in preparing a medicine or product for preventing and treating dementia, and a preparation method thereof, which belong to the fields of medicines and health care products, and its products comprise a topical preparation, oral preparation and injection of the ginsenoside Rg3; and the Rg3 medicine or formulating prepared Rg3 compound medicine is prepared by using a solubilizer, a transdermal agent, a reagent promoting the absorption by penetrating a blood-brain barrier and an extractive, achieving the effect that the medicine penetrates the blood-brain barrier, and is used for preventing and treating dementia.

Abstract translation: 本发明公开了人参皂苷Rg3在制备用于预防和治疗痴呆症的药物或产品中的应用及其制备方法，其属于药物和保健品领域，其产品包括局部制剂，口服制剂和 注射人参皂甙Rg3; 通过使用增溶剂，透皮剂，通过渗透血脑屏障和提取物促进吸收的试剂，实现药物渗透血脑屏障的作用，制备Rg3药物或配制的Rg3化合物药物， 并用于预防和治疗痴呆症。