公开(公告)号：US20140221620A1

公开(公告)日：2014-08-07

申请号：US14129049

申请日：2012-06-19

申请人： Lilin Zhang ,  Katsuyuki Mimoti ,  Katsushi Kouda ,  Yoko Kayukawa

发明人： Lilin Zhang ,  Katsuyuki Mimoti ,  Katsushi Kouda ,  Yoko Kayukawa

IPC分类号： C07K16/28

CPC分类号： C07K16/28 ,  A61K39/395 ,  A61K2039/505 ,  C07K16/46 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/732 ,  C12N5/10 ,  C12N15/09 ,  G01N33/53 ,  G01N33/57484

摘要： It is an object to provide a recombinant antibody that is an anti-CDH3 antibody having cytotoxicity on CDH3-expressing cells, which is anticipated to have fewer side effects than antibodies derived from animals other than humans and to maintain its therapeutic effects for a long period of time. The present invention provides a recombinant antibody which specifically reacts with an epitope existing in the amino acids at positions 108 to 131 or at positions 551 to 654 of the amino acid sequence shown in SEQ ID NO: 38 that is the extracellular region of human CDH3, and has cytotoxicity against CDH3-expressing cells.

摘要翻译： 本发明的目的是提供一种抗CDH3抗体的重组抗体，其具有对表达CDH3的细胞具有细胞毒性的抗CDH3抗体，其预期比来自除人以外的动物的抗体具有较少的副作用并长期保持其治疗效果 的时间。 本发明提供了与存在于SEQ ID NO：38所示氨基酸序列的位置108至131或位于第551至654位的表位存在的表位的重组抗体，所述氨基酸序列是人CDH3的胞外区， 并对CDH3表达细胞具有细胞毒性。