专利检索 ap:("Ludwig Institute for Cancer Research Ltd" OR "The Wistar Institute") AND inv:"Yaoyu Gong" 第 1 页

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发明申请
IMMUNE CELLS WITH ENHANCED CYTOTOXICITY AND METHODS OF USE THEREOF 有权

公开(公告)号：US20220267781A1

公开(公告)日：2022-08-25

申请号：US17630068

申请日：2020-07-24

申请人： Ludwig Institute for Cancer Research Ltd , The Wistar Institute

发明人： Zandra Walton , Zachary Stine , Yaoyu Gong , Chi Van Dang

IPC分类号： C12N15/62 , A61K35/17 , C07K14/47 , C07K14/705 , C12N5/0783 , C12N9/12 , C12N9/88

摘要： This disclosure provides methods for enhancing antitumor cytotoxicity of immune cells by introducing to the immune cells a genetic modification that comprises overexpression of RHEB or a functional fragment thereof, overexpression of LAMP 1-RHEB or a functional fragment thereof, overexpression of CA9 or a functional fragment thereof, overexpression of NHE1 or a functional fragment thereof, or combination thereof.