公开(公告)号：US20220193251A1

公开(公告)日：2022-06-23

申请号：US17559664

申请日：2021-12-22

申请人： Ludwig-Maximilians-Universitaet Muenchen ,  Forschungsverbund Berlin e.V.

发明人： Heinrich LEONHARDT ,  Jonas HELMA-SMETS ,  Dominik SCHUMACHER ,  Marcus GERLACH ,  Christian PR HACKENBERGER ,  Marc-André KASPER

IPC分类号： A61K47/68

摘要： The present invention relates to an antibody-drug conjugate (ADC) comprising: (a) Brentuximab, wherein Brentuximab comprises at the C-terminus of the light chains, the heavy chains or all of the heavy and light chains of the Brentuximab a recognition sequence for tubulin tyrosine ligase and a non-natural amino acid; and (b) at least one drug moiety; wherein a drug moiety is coupled to each of the non-natural amino acids via a linker. The present invention further relates to methods of producing same, pharmaceutical compositions comprising same as well as uses thereof.

公开(公告)号：US20210246189A1

公开(公告)日：2021-08-12

申请号：US17250769

申请日：2019-08-30

申请人： TECHNISCHE UNIVERSITAET MUENCHEN ,  LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

发明人： Dirk BUSCH ,  Manuel EFFENBERGER ,  Heinrich LEONHARDT ,  Andreas STENGL

IPC分类号： C07K14/74 ,  C12N9/52 ,  G01N33/569 ,  G01N33/58

摘要： The present invention relates to a peptide comprising a reversible affinity tag (A); and a functionalization tag (F), wherein the peptide is linked to a target of interest (T). The peptide is useful as a versatile protein tag. The invention further provides structures comprising the peptide, nucleic acids, vectors, and host cells. Further, the invention provides methods of producing or using the peptide.

公开(公告)号：US20210040145A1

公开(公告)日：2021-02-11

申请号：US16993877

申请日：2020-08-14

申请人： LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN ,  FORSCHUNGSVERBUND BERLIN E.V.

发明人： Heinrich LEONHARDT ,  Jonas HELMA ,  Dominik SCHUMACHER ,  Christian HACKENBERGER

IPC分类号： C07K1/107 ,  C12P21/02 ,  C12P21/00

摘要： The present invention provides means and methods for equipping a polypeptide of interest at its C-terminus with a versatile adaptor amino acid that allows the functionalization of the polypeptide of interest.

公开(公告)号：US20220363714A1

公开(公告)日：2022-11-17

申请号：US17853591

申请日：2022-06-29

申请人： LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN ,  FORSCHUNGSVERBUND BERLIN E.V.

发明人： Heinrich LEONHARDT ,  Jonas HELMA ,  Dominik SCHUMACHER ,  Christian HACKENBERGER

IPC分类号： C07K1/107 ,  C12P21/02 ,  C12P21/00

摘要： The present invention provides means and methods for equipping a polypeptide of interest at its C-terminus with a versatile adaptor amino acid that allows the functionalization of the polypeptide of interest.

公开(公告)号：US20190337977A1

公开(公告)日：2019-11-07

申请号：US16225522

申请日：2018-12-19

申请人： LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN ,  FORSCHUNGSVERBUND BERLIN E.V.

发明人： Heinrich LEONHARDT ,  Jonas HELMA ,  Dominik SCHUMACHER ,  Christian HACKENBERGER

IPC分类号： C07K1/107 ,  C12P21/00 ,  C12P21/02

摘要： The present invention provides means and methods for equipping a polypeptide of interest at its C-terminus with a versatile adaptor amino acid that allows the functionalization of the polypeptide of interest.

公开(公告)号：US20190144493A1

公开(公告)日：2019-05-16

申请号：US16096787

申请日：2017-04-27

申请人： FORSCHUNGSVERBUND BERLIN E.V. ,  LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN

发明人： Christian HACKENBERGER ,  Dominik SCHUMACHER ,  Jonas HELMA ,  Heinrich LEONHARDT

IPC分类号： C07K1/107 ,  C12P21/02

摘要： The present invention provides means and methods for functionalizing a polypeptide of interest at its C-terminus with an amino acid derivative.