公开(公告)号：US20150362496A1

公开(公告)日：2015-12-17

申请号：US14237682

申请日：2012-08-08

申请人： Luis Barneo Serra ,  Carmen Garcia Pravia ,  Juan Ramon De Los Toyos Gonzalez ,  Marcos Garcia Ocana ,  Jose Fernando Vazquez Villa ,  Nelson Fuentes Martinez ,  Jokin Del Amo Iribarren ,  Laureano Simon Buela

发明人： Luis Barneo Serra ,  Carmen Garcia Pravia ,  Juan Ramon De Los Toyos Gonzalez ,  Marcos Garcia Ocana ,  Jose Fernando Vazquez Villa ,  Nelson Fuentes Martinez ,  Jokin Del Amo Iribarren ,  Laureano Simon Buela

IPC分类号： G01N33/574 ,  C12Q1/68

CPC分类号： G01N33/57484 ,  C07K16/18 ,  C07K16/30 ,  C07K2317/33 ,  C12Q1/6886 ,  C12Q2600/118 ,  G01N33/5011 ,  G01N33/6881 ,  G01N33/6887 ,  G01N2333/78 ,  G01N2800/56

摘要： The present invention relates to in vitro methods and products for detecting the presence of an invasive carcinoma in an individual, for determining and/or predicting the stage and/or invasiveness of said carcinoma in an individual, or for monitoring the effect of the therapy administered to an individual who has said carcinoma based on col11a1 gene and proCOL11A1 protein expression. The invention also relates to the search for, identification, development and evaluation of the efficacy of compounds for therapy for said carcinoma, for the purpose of developing new medicinal products. The invention also relates to agents inhibiting proCOL11A1 protein expression and/or activity, and/or the effects of this expression.

摘要翻译： 本发明涉及用于检测个体侵袭性癌的存在的体外方法和产品，用于确定和/或预测个体中所述癌的阶段和/或侵袭性，或用于监测施用的治疗的效果 对具有基于col11a1基因和proCOL11A1蛋白表达的癌症的个体。 本发明还涉及为了开发新的药用产品而寻求，鉴定，开发和评估化合物治疗所述癌症的功效。 本发明还涉及抑制proCOL11A1蛋白表达和/或活性的药剂和/或该表达的作用。

公开(公告)号：US09702879B2

公开(公告)日：2017-07-11

申请号：US14237682

申请日：2012-08-08

申请人： Luis Barneo Serra ,  Carmen Garcia Pravia ,  Juan Ramon De Los Toyos Gonzalez ,  Marcos Garcia Ocana ,  Jose Fernando Vazquez Villa ,  Nelson Fuentes Martinez ,  Jokin Del Amo Iribarren ,  Laureano Simon Buela

发明人： Luis Barneo Serra ,  Carmen Garcia Pravia ,  Juan Ramon De Los Toyos Gonzalez ,  Marcos Garcia Ocana ,  Jose Fernando Vazquez Villa ,  Nelson Fuentes Martinez ,  Jokin Del Amo Iribarren ,  Laureano Simon Buela

IPC分类号： G01N33/573 ,  G01N33/574 ,  C07K16/18 ,  C07K16/30 ,  G01N33/50 ,  G01N33/68 ,  C12Q1/68

CPC分类号： G01N33/57484 ,  C07K16/18 ,  C07K16/30 ,  C07K2317/33 ,  C12Q1/6886 ,  C12Q2600/118 ,  G01N33/5011 ,  G01N33/6881 ,  G01N33/6887 ,  G01N2333/78 ,  G01N2800/56

摘要： The present invention relates to in vitro methods and products for detecting the presence of an invasive carcinoma in an individual, for determining and/or predicting the stage and/or invasiveness of said carcinoma in an individual, or for monitoring the effect of the therapy administered to an individual who has said carcinoma based on col11a1 gene and proCOL11A1 protein expression. The invention also relates to the search for, identification, development and evaluation of the efficacy of compounds for therapy for said carcinoma, for the purpose of developing new medicinal products. The invention also relates to agents inhibiting proCOL11A1 protein expression and/or activity, and/or the effects of this expression.