公开(公告)号：US20230066014A1

公开(公告)日：2023-03-02

申请号：US17782214

申请日：2020-12-02

申请人： Lupin Limited

发明人： Prathap Sreedharan NAIR ,  Ganesh Bhausaheb GUDADE ,  Shankar Bhaskar BHAGWAT ,  Amol Maruti YADAV ,  Chaitanya Prabhakar KULKARNI ,  Milind Dattatraya SINDKHEDKAR ,  Venkata P. PALLE ,  Rajender Kumar KAMBOJ

IPC分类号： A61K31/473 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/536 ,  A61P35/00

摘要： The invention relates to substituted nucleoside analogues of formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions for treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme. The invention also relates to methods of treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme.