公开(公告)号：US20230119316A1

公开(公告)日：2023-04-20

申请号：US17789293

申请日：2020-12-27

申请人： Lupin Limited

发明人： Sanjay Pralhad Kurhade ,  Prathap Sreedharan Nair ,  Sachin Sethi ,  Manojkumar Ramprasad Shukla ,  Milind Dattatraya Sindkhedkar ,  Venkata P. Palle ,  Rajender Kumar Kamboj ,  Samiron Phukan ,  Pradeep Rangrao Patil ,  Sayyed Majid ,  Ramesh Phadatare ,  Navnath Walke ,  Vipul Pachpute ,  Balasaheb Gore ,  Vikas Tambe ,  Rohan Limaye ,  Avadhut Bhosale ,  Sachin Mahangare

IPC分类号： C07D498/04 ,  A61K31/5383 ,  C07D491/052 ,  A61K31/519 ,  C07D487/04 ,  C07D471/04 ,  C07D487/10 ,  C07D491/20 ,  C07D498/20 ,  A61P35/00

摘要： Disclosed are compounds of the general formula (I), its tautomeric form, its stereoisomer, its pharmaceutically acceptable salt, its polymorph, or solvate thereof, wherein, ring A, ring B, R1 to R4, and n are as defined herein, for use as SOS1 inhibitors in the treatment of proliferative, infectious and RASopathy diseases or disorders. Also disclosed are methods of synthesizing the compound of formula I, pharmaceutical compositions containing the compound of formula I, method of treatment of proliferative, infectious and RASopathy diseases or disorder, for example, a cancer, by administering the said compound and combinations of the compound of formula I with other active ingredients.