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    Aldophosphamide glycosides, a process for their preparation and their use as pharmaceutical active compounds
    1.
    发明授权
    Aldophosphamide glycosides, a process for their preparation and their use as pharmaceutical active compounds 失效
    二磷酸糖苷，其制备方法及其作为药物活性化合物的用途

    公开(公告)号：US5126437A

    公开(公告)日：1992-06-30

    申请号：US362902

    申请日：1989-06-07

    申请人： Lutz-F. Tietze ,  Manfred Neumann ,  Roland Fischer

    发明人： Lutz-F. Tietze ,  Manfred Neumann ,  Roland Fischer

    IPC分类号： A61K31/70 ,  A61K31/7028 ,  A61P35/00 ,  C07H15/04

    CPC分类号： C07H15/04

    摘要： Compounds of the formula ##STR1## in which R.sup.1 represents saturated, unsaturated or anhydro desoxypentosyl, desoxyhexosyl or didesoxyhexosyl, where the OH functions of the sugar are optionally protected, andR.sup.2 represents straight-chain or branched or heterosubstituted alkyl having up to ten carbon atoms andR.sup.3 represents straight-chain or branched or heterosubstituted alkyl having up to ten carbon atoms andX represents halogens andR.sup.4 represents straight-chain or branched or heterosubstituted alkyl having up to ten carbon atoms.Such compounds are useful as highly selective cytostatics in cancer therapy.

    摘要翻译： 其中R1表示饱和，不饱和或脱水脱氧素，脱氧己糖基或二氧代己糖基，其中糖的OH官能团任选被保护，并且R 2表示直链的化合物 具有至多10个碳原子的链或支链或杂取代的烷基，R 3表示具有至多10个碳原子的直链或支链或杂取代的烷基，X表示卤素，R4表示直链或支链或含有至多10个碳原子的支链或杂取代的烷基 原子 这些化合物可用作癌症治疗中的高选择性细胞抑制剂。