公开(公告)号：US20160177296A1

公开(公告)日：2016-06-23

申请号：US14604252

申请日：2015-01-23

申请人： Lyndsey M. Linke ,  Mo D. Salman ,  Jeffrey Wilusz

发明人： Lyndsey M. Linke ,  Mo D. Salman ,  Jeffrey Wilusz

IPC分类号： C12N15/113 ,  C12N15/70 ,  A61K48/00

CPC分类号： C12N15/113 ,  A01N63/00 ,  A61K31/7105 ,  A61K48/0075 ,  C12N15/1131 ,  C12N15/70 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/31 ,  C12N2320/32 ,  C12N2330/51 ,  C12N2760/16111

摘要： Product, and associated methods are described for the delivery of one or more small interfering RNAs (siRNAs) to an avian cell using a nonpathogenic bacterium for the prevention or treatment of Avian Influenza Virus (AIV). The siRNA is complementary to an mRNA of the AIV NP or PA sequence. In challenge studies with chickens, the siRNA is shown to prevent the onset of clinical symptoms or reduce the severity of disease, including reducing viral titers or virus shedding.

摘要翻译： 描述了使用非致病性细菌将一种或多种小干扰RNA（siRNA）递送至禽类细胞用于预防或治疗禽流感病毒（AIV）的产物和相关方法。 siRNA与AIV NP或PA序列的mRNA互补。 在鸡的攻击研究中，siRNA显示可以防止临床症状的发作或降低疾病的严重程度，包括降低病毒滴度或病毒脱落。

公开(公告)号：US20190284559A1

公开(公告)日：2019-09-19

申请号：US16431448

申请日：2019-06-04

申请人： Lyndsey M. Linke ,  Mo D. Salman ,  Jeffrey Wilusz

发明人： Lyndsey M. Linke ,  Mo D. Salman ,  Jeffrey Wilusz

IPC分类号： C12N15/113 ,  A61K31/7105 ,  A01N63/00 ,  A61K48/00 ,  C12N15/70

摘要： Products and associated methods are described for the delivery of one or more small interfering RNAs (siRNAs) to an avian cell using a nonpathogenic bacterium for the prevention or treatment of Avian Influenza Virus (AIV). The siRNA is complementary to an mRNA of the AIV NP or PA sequence. In challenge studies with chickens, the siRNA is shown to prevent the onset of clinical symptoms or reduce the severity of disease, including reducing viral titers or virus shedding.