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公开(公告)号:US06376222B1
公开(公告)日:2002-04-23
申请号:US09299041
申请日:1999-04-23
申请人: Lyubov Ya. Babyak , Adelbert Bacher , Yuriy R. Boretskyy , Vasyl V. Demchyshyn , Sabine Eberhardt , Dariya Fedorovych , Holger Lüttgen , Gerald Richter , Adolphus van Loon
发明人: Lyubov Ya. Babyak , Adelbert Bacher , Yuriy R. Boretskyy , Vasyl V. Demchyshyn , Sabine Eberhardt , Dariya Fedorovych , Holger Lüttgen , Gerald Richter , Adolphus van Loon
IPC分类号: C12P1718
CPC分类号: C12N15/81 , A23K20/00 , A23L33/15 , A23V2002/00 , C12N9/78 , C12P25/00 , A23V2250/7044
摘要: The present invention provides a transformed yeast strain containing a DNA sequence transcriptionally linked to a promoter functional in such yeast cells, which when expressed in a suitable host cell, encodes at least one polypeptide having riboflavin biosynthetic activity. Using such transformants, improved levels of riboflavin production are achieved. Processes of producing riboflavin from such transformants are also provided.
摘要翻译: 本发明提供一种转化的酵母菌株,其含有与在这样的酵母细胞中有功能的启动子转录连接的DNA序列,当在合适的宿主细胞中表达时,编码至少一种具有核黄素生物合成活性的多肽。 使用这种转化体,可以实现核黄素生产水平的提高。 还提供了从这种转化体生产核黄素的方法。