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公开(公告)号：US20080219965A1
公开(公告)日：2008-09-11
申请号：US11942220
申请日：2007-11-19
Applicant: Allan Svendsen , Soren Flensted Lassen , Dirk Kostrewa , Luis Pasamontes , Martin Lehmann , Andrea Tomschy , Adolphus Van Loon , Kurt Vogel , Markus Wyss
Inventor： Allan Svendsen , Soren Flensted Lassen , Dirk Kostrewa , Luis Pasamontes , Martin Lehmann , Andrea Tomschy , Adolphus Van Loon , Kurt Vogel , Markus Wyss
CPC classification number: C12N15/8257 , A23K10/14 , A23K20/189 , C12N9/16 , C12N15/8242 , C12N15/8243 , Y10S435/911 , Y10S435/916
Abstract: The present invention relates to phytase variants, their preparation and uses, which phytase variants, when aligned according to FIG. 1, are amended as compared to a model phytase in at least one of a number of positions. Preferred model phytases are basidiomycete and ascomycete phytases, such as Peniophora phytase and Aspergillus phytases. Preferred phytase variants exhibits amended activity characteristics, such as improved specific activity and/or improved thermostability.
Abstract translation: 本发明涉及植酸酶变体，其制备和用途，当植酸酶变体在根据图1对齐时。 与在多个位置中的至少一个中的模型植酸酶相比，修改了1。 优选的植酸酶类型是担子菌和子囊菌植酸酶，如Peniophora植酸酶和曲霉属植酸酶。 优选的植酸酶变体表现出修正的活性特征，例如提高的比活性和/或改善的热稳定性。
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公开(公告)号：US06514495B1
公开(公告)日：2003-02-04
申请号：US09273871
申请日：1999-03-22
Applicant: Allan Svendsen , Søren Flensted Lassen , Dirk Kostrewa , Luis Pasamontes , Martin Lehmann , Andrea Tomschy , Adolphus Van Loon , Kurt Vogel , Markus Wyss
Inventor： Allan Svendsen , Søren Flensted Lassen , Dirk Kostrewa , Luis Pasamontes , Martin Lehmann , Andrea Tomschy , Adolphus Van Loon , Kurt Vogel , Markus Wyss
IPC: A61K3846
CPC classification number: C12N15/8257 , A23K10/14 , A23K20/189 , C12N9/16 , C12N15/8242 , C12N15/8243 , Y10S435/911 , Y10S435/916
Abstract: Phytase variants, their preparation and uses, which phytase variants, when aligned according to FIG. 1, are amended as compared to a model phytase in at least one of a number of positions. Preferred model phytases are basidiomycete and ascomycete phytases, such as Peniophora phytase and Aspergillus phytases. Preferred phytase variants exhibits amended activity characteristics, such as improved specific activity and/or improved thermostability.
Abstract translation: 植酸酶变体，它们的制备和用途，当植酸酶变体根据图1对齐时， 与在多个位置中的至少一个中的模型植酸酶相比，修改了1。 优选的植酸酶类型是担子菌和子囊菌植酸酶，如Peniophora植酸酶和曲霉属植酸酶。 优选的植酸酶变体表现出修正的活性特征，例如提高的比活性和/或改善的热稳定性。
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公开(公告)号：US06204012B1
公开(公告)日：2001-03-20
申请号：US09163052
申请日：1998-09-29
Applicant: Karsten Hellmuth , Rual Lopez-Ulibarri , Anne Françoise Mayer , Heinrich Winfried Schlieker , Adolphus van Loon
Inventor： Karsten Hellmuth , Rual Lopez-Ulibarri , Anne Françoise Mayer , Heinrich Winfried Schlieker , Adolphus van Loon
IPC: C12P2106
Abstract: A method for producing a protein by culturing a cell capable of expressing the protein and which contains a methylotrophic yeast promoter for an enzyme of the methanol metabolic pathway controlling expression of the protein, in a fermentative batch process comprising a batch phase and a feeding phase, under conditions such that dissolved oxygen is continually present in the culture medium throughout the process, and about 1% to about 100% of the carbon source during the feeding phase is a sugar or sugar polymer, which sugar or sugar polymer is provided in such an amount that the sugar or sugar polymer is continually depleted by the cell and therefore is substantially undetectable in the culture medium; and isolating the protein on completion of the feeding phase.
Abstract translation: 一种生产蛋白质的方法，该方法通过培养能够表达该蛋白质的细胞并且在包含间歇期和进食期的发酵分批方法中含有用于控制蛋白质表达的甲醇代谢途径的酶的甲基营养酵母启动子， 在整个过程中在培养基中连续存在溶解氧的条件下，并且在进料阶段期间约1％至约100％的碳源是糖或糖聚合物，所述糖或糖聚合物以这样的形式提供 量的糖或糖聚合物不断被细胞耗尽，因此在培养基中基本上是不可检测的; 并在进料阶段完成时分离蛋白质。
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公开(公告)号：US20080220118A1
公开(公告)日：2008-09-11
申请号：US11942242
申请日：2007-11-19
Applicant: Allan Svendsen , Soren Flensted Lassen , Dirk Kostrewa , Luis Pasamontes , Martin Lehman , Andrea Tomschy , Adolphus Van Loon , Kurt Vogel , Markus Wyss
Inventor： Allan Svendsen , Soren Flensted Lassen , Dirk Kostrewa , Luis Pasamontes , Martin Lehman , Andrea Tomschy , Adolphus Van Loon , Kurt Vogel , Markus Wyss
CPC classification number: C12N15/8257 , A23K10/14 , A23K20/189 , C12N9/16 , C12N15/8242 , C12N15/8243 , Y10S435/911 , Y10S435/916
Abstract: The present invention relates to phytase variants, their preparation and uses, which phytase variants, when aligned according to FIG. 1, are amended as compared to a model phytase in at least one of a number of positions. Preferred model phytases are basidiomycete and ascomycete phytases, such as Peniophora phytase and Aspergillus phytases. Preferred phytase variants exhibits amended activity characteristics, such as improved specific activity and/or improved thermostability.
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公开(公告)号：US07326554B2
公开(公告)日：2008-02-05
申请号：US10734510
申请日：2003-12-12
Applicant: Allan Svendsen , Soren Flensted Lassen , Dirk Kostrewa , Luis Pasamontes , Martin Lehman , Andrea Tomschy , Adolphus Van Loon , Kurt Vogel , Markus Wyss
Inventor： Allan Svendsen , Soren Flensted Lassen , Dirk Kostrewa , Luis Pasamontes , Martin Lehman , Andrea Tomschy , Adolphus Van Loon , Kurt Vogel , Markus Wyss
IPC: C12N9/16
CPC classification number: C12N15/8257 , A23K10/14 , A23K20/189 , C12N9/16 , C12N15/8242 , C12N15/8243 , Y10S435/911 , Y10S435/916
Abstract: The present invention relates to phytase variants, their preparation and uses, which phytase variants, when aligned according to FIG. 1, are amended as compared to a model phytase in at least one of a number of positions. Preferred model phytases are basidiomycete and ascomycete phytases, such as Peniophora phytase and Aspergillus phytases. Preferred phytase variants exhibits amended activity characteristics, such as improved specific activity and/or improved thermostability.
Abstract translation: 本发明涉及植酸酶变体，其制备和用途，当植酸酶变体在根据图1对齐时。 与在多个位置中的至少一个中的模型植酸酶相比，修改了1。 优选的植酸酶类型是担子菌和子囊菌植酸酶，如Peniophora植酸酶和曲霉属植酸酶。 优选的植酸酶变体表现出修正的活性特征，例如提高的比活性和/或改善的热稳定性。
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Patent Agency Ranking
公开(公告)号：US06734004B2
公开(公告)日：2004-05-11
申请号：US10062848
申请日：2002-02-01
Applicant: Dirk Kostrewa , Luis Pasamontes , Andrea Tomschy , Adolphus van Loon , Kurt Vogel , Markus Wyss
Inventor： Dirk Kostrewa , Luis Pasamontes , Andrea Tomschy , Adolphus van Loon , Kurt Vogel , Markus Wyss
IPC: C12N916
CPC classification number: C12N9/16 , A23K20/189 , Y10S435/913 , Y10S435/916 , Y10S435/917
Abstract: A process for the production of a modified phytase with a desired property improved over the property of the corresponding unmodified phytase is disclosed, as well as modified phytases, polynucleotides encoding modified phytases, and animal feed including modified phytases.
Abstract translation: 公开了生产具有相对于未修饰的植酸酶的性质改进的所需性质的修饰植酸酶的方法，以及修饰的植酸酶，编码修饰的植酸酶的多核苷酸和包括修饰的植酸酶的动物饲料。
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公开(公告)号：US06391605B1
公开(公告)日：2002-05-21
申请号：US09044718
申请日：1998-03-19
Applicant: Dirk Kostrewa , Luis Pasamontes , Andrea Tomschy , Adolphus van Loon , Kurt Vogel , Markus Wyss
Inventor： Dirk Kostrewa , Luis Pasamontes , Andrea Tomschy , Adolphus van Loon , Kurt Vogel , Markus Wyss
IPC: C12N916
CPC classification number: C12N9/16 , A23K20/189 , Y10S435/913 , Y10S435/916 , Y10S435/917
Abstract: A process for the production of a modified phytase with a desired property improved over the property of the corresponding unmodified phytase is disclosed, as well as modified phytases, polynucleotides encoding modified phytases, and animal feed including modified phytases.
Abstract translation: 公开了生产具有相对于未修饰的植酸酶的性质改进的所需性质的修饰植酸酶的方法，以及修饰的植酸酶，编码修饰的植酸酶的多核苷酸，以及包括修饰的植酸酶的动物饲料。
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公开(公告)号：US06291221B1
公开(公告)日：2001-09-18
申请号：US08868435
申请日：1997-06-03
Applicant: Adolphus van Loon , David Mitchell
Inventor： Adolphus van Loon , David Mitchell
IPC: C12N916
CPC classification number: C12N9/14 , A23K20/168 , A23K40/20 , C12N9/16
Abstract: The present invention relates to heat tolerant phytases and DNA sequences which code therefor. The phytases are useful in hydrolyzing phytate to inositol and inorganic phosphates. The phytases are valuable feed additives.
Abstract translation: 本发明涉及编码耐热植酸酶和DNA序列。 肌醇六磷酸酶可以将植酸盐水解成肌醇和无机磷酸盐。 植酸酶是有价值的饲料添加剂。
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公开(公告)号：US6087152A
公开(公告)日：2000-07-11
申请号：US660645
申请日：1996-06-07
Applicant: Hans-Peter Hohmann , Luis Pasamontes , Michel Tessier , Adolphus van Loon
Inventor： Hans-Peter Hohmann , Luis Pasamontes , Michel Tessier , Adolphus van Loon
IPC: A23K1/16 , A23L1/30 , C07H21/04 , C07K14/195 , C12N1/21 , C12N15/09 , C12N15/52 , C12N15/53 , C12P7/04 , C12P23/00 , C12R1/05 , C12R1/125 , C12R1/19 , C12R1/20 , C12N1/20
CPC classification number: C12N15/52 , C07K14/195 , C12P23/00
Abstract: Novel proteins of Flavobacterium sp. R1534 and the DNA sequences which encode these proteins are disclosed which provide an improved biosynthetic pathway from farnesyl pyrophosphate and isopentyl pyrophosphate to various carotenoid precursors and carotenoids, especially .beta.-carotene, lycopene, zeaxanthin and cantaxanthin.
Abstract translation: 黄杆菌新蛋白 公开了编码这些蛋白质的DNA序列，其提供了从法呢基焦磷酸盐和异戊基焦磷酸盐到各种类胡萝卜素前体和类胡萝卜素，特别是β-胡萝卜素，番茄红素，玉米黄质和角质黄素的改进的生物合成途径。
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公开(公告)号：US07078183B2
公开(公告)日：2006-07-18
申请号：US10776104
申请日：2004-02-11
Applicant: Dirk Kostrewa , Luis Pasamontes , Andrea Tomschy , Adolphus van Loon , Kurt Vogel , Markus Wyss
Inventor： Dirk Kostrewa , Luis Pasamontes , Andrea Tomschy , Adolphus van Loon , Kurt Vogel , Markus Wyss
CPC classification number: C12N9/16 , A23K20/189 , Y10S435/913 , Y10S435/916 , Y10S435/917
Abstract: A process for the production of a modified phytase with a desired property improved over the property of the corresponding unmodified phytase is disclosed, as well as modified phytases, polynucleotides encoding modified phytases, and animal feed including modified phytases.
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