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公开(公告)号:US09730885B2
公开(公告)日:2017-08-15
申请号:US13939357
申请日:2013-07-11
申请人: Mallinckrodt LLC
IPC分类号: A61K9/00 , A61K9/20 , A61K9/28 , A61K31/485
CPC分类号: A61K9/0002 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/28 , A61K31/485
摘要: Pharmaceutical compositions comprising at least one active pharmaceutical ingredient or a pharmaceutically acceptable salt thereof, at least one hydrophilic plastomer, at least one hydrophilic elastomer, and at least one deliquescent plasticizer, wherein the pharmaceutical compositions provide extended release of the API and have abuse deterrent properties. Methods for preparing the pharmaceutical compositions in which the components of the composition are humidified such that the deliquescent plasticizer deliquesces, thereby plasticizing the hydrophilic polymers.
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公开(公告)号:US09993422B2
公开(公告)日:2018-06-12
申请号:US13865286
申请日:2013-04-18
申请人: Mallinckrodt LLC
发明人: Siva N. Raman , Jae Han Park , Thomas A. Diezi , Clifford J. Herman , Sunil K. Battu , Eric A. Burge
IPC分类号: A61K9/46 , A61K45/06 , A61K9/20 , A61K31/485
CPC分类号: A61K9/0007 , A61K9/2031 , A61K31/485 , A61K45/06 , A61K2300/00
摘要: The present disclosure provides pharmaceutical compositions and processes for making solid dosage form pharmaceutical compositions that provide immediate release of active ingredients and have abuse deterrent properties. The pharmaceutical compositions provided herein comprise at least one pharmaceutically active ingredient, at least one low molecular weight hydrophilic polymer, at least one high molecular weight hydrophilic polymer, and an effervescent system.
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公开(公告)号:US20170224826A1
公开(公告)日:2017-08-10
申请号:US15417541
申请日:2017-01-27
申请人: MALLINCKRODT LLC
发明人: Brad L. Gower , Jae Han Park , Clifford J. Herman , Tsz Chung Lai , Kai Feng
IPC分类号: A61K47/36 , A61K31/485 , A61K47/34
CPC分类号: A61K31/485 , A61K9/2013 , A61K9/2031 , A61K9/205 , A61K9/2054
摘要: A pharmaceutical composition comprising at least one active pharmaceutical ingredient (API) or a pharmaceutically acceptable salt thereof, a glucomannan, a first polyalkylene oxide having an average molecular weight of no more than 300,000, and a second polyalkylene oxide having an average molecular weight of at least 1,000,000 and methods of making. The pharmaceutical composition provides extended release of the API and has abuse deterrent features.
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公开(公告)号:US20170143699A1
公开(公告)日:2017-05-25
申请号:US15420386
申请日:2017-01-31
申请人: Mallinckrodt LLC
IPC分类号: A61K31/485 , A61K9/28 , A61K9/20
CPC分类号: A61K9/0002 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/28 , A61K31/485
摘要: Pharmaceutical compositions comprising at least one active pharmaceutical ingredient or a pharmaceutically acceptable salt thereof, at least one hydrophilic plastomer, at least one hydrophilic elastomer, and at least one deliquescent plasticizer, wherein the pharmaceutical compositions provide extended release of the API and have abuse deterrent properties. Methods for preparing the pharmaceutical compositions in which the components of the composition are humidified such that the deliquescent plasticizer deliquesces, thereby plasticizing the hydrophilic polymers.
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公开(公告)号:US20180256493A1
公开(公告)日:2018-09-13
申请号:US15977415
申请日:2018-05-11
申请人: Mallinckrodt LLC
发明人: Siva N. Raman , Jae Han Park , Thomas A. Diezi , Clifford J. Herman , Sunil K. Battu , Eric A. Burge
IPC分类号: A61K9/46 , A61K31/485 , A61K45/06 , A61K9/20
CPC分类号: A61K9/0007 , A61K9/2031 , A61K31/485 , A61K45/06 , A61K2300/00
摘要: The present disclosure provides pharmaceutical compositions and processes for making solid dosage form pharmaceutical compositions that provide immediate release of active ingredients and have abuse deterrent properties. The pharmaceutical compositions provided herein comprise at least one pharmaceutically active ingredient, at least one low molecular weight hydrophilic polymer, at least one high molecular weight hydrophilic polymer, and an effervescent system.
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公开(公告)号:US20180008532A1
公开(公告)日:2018-01-11
申请号:US15714137
申请日:2017-09-25
申请人: Mallinckrodt LLC
发明人: Siva N. Raman , Jae Han Park , Thomas A. Diezi , Clifford J. Herman , Sunil K. Battu , Eric A. Burge
IPC分类号: A61K9/46 , A61K9/20 , A61K31/485 , A61K45/06
CPC分类号: A61K9/0007 , A61K9/2031 , A61K31/485 , A61K45/06 , A61K2300/00
摘要: The present disclosure provides pharmaceutical compositions and processes for making solid dosage form pharmaceutical compositions that provide immediate release of active ingredients and have abuse deterrent properties. The pharmaceutical compositions provided herein comprise at least one pharmaceutically active ingredient, at least one low molecular weight hydrophilic polymer, at least one high molecular weight hydrophilic polymer, and an effervescent system.
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公开(公告)号:US20140017310A1
公开(公告)日:2014-01-16
申请号:US13939357
申请日:2013-07-11
申请人: Mallinckrodt LLC
CPC分类号: A61K9/0002 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/28 , A61K31/485
摘要: The present disclosure provides pharmaceutical compositions comprising at least one active pharmaceutical ingredient or a pharmaceutically acceptable salt thereof, at least one hydrophilic plastomer, optionally at least one hydrophilic elastomer, and at least one deliquescent plasticizer, wherein the pharmaceutical compositions provide extended release of the API and have abuse deterrent properties. Also provided are methods for preparing the pharmaceutical compositions in which the components of the composition are humidified such that the deliquescent plasticizer deliquesces, thereby plasticizing the hydrophilic polymers.
摘要翻译: 本公开提供包含至少一种活性药物成分或其药学上可接受的盐,至少一种亲水性塑性体,任选的至少一种亲水弹性体和至少一种潮解增塑剂的药物组合物,其中所述药物组合物提供API的延长释放 并具有滥用威慑性质。 还提供了制备药物组合物的方法,其中组合物的组分被加湿,使得潮解性增塑剂脱水,从而增塑亲水性聚合物。
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公开(公告)号:US20130280177A1
公开(公告)日:2013-10-24
申请号:US13865286
申请日:2013-04-18
申请人: MALLINCKRODT LLC
IPC分类号: A61K9/46
CPC分类号: A61K9/0007 , A61K9/2031 , A61K31/485 , A61K45/06 , A61K2300/00
摘要: The present disclosure provides pharmaceutical compositions and processes for making solid dosage form pharmaceutical compositions that provide immediate release of active ingredients and have abuse deterrent properties. The pharmaceutical compositions provided herein comprise at least one pharmaceutically active ingredient, at least one low molecular weight hydrophilic polymer, at least one high molecular weight hydrophilic polymer, and an effervescent system.
摘要翻译: 本公开提供了制备固体剂型药物组合物的药物组合物和方法,其提供活性成分的立即释放并具有滥用威慑性质。 本文提供的药物组合物包含至少一种药物活性成分,至少一种低分子量亲水聚合物,至少一种高分子量亲水聚合物和泡腾系统。
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