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1.发明申请公开(公告)号：US20170095470A1
公开(公告)日：2017-04-06
申请号：US15385812
申请日：2016-12-20
申请人： MALLINCKRODT LLC
IPC分类号： A61K31/485 , A61K9/00 , A61K9/20 , A61K31/167
CPC分类号： A61K31/485 , A61K9/0053 , A61K9/2031 , A61K9/2086 , A61K9/209 , A61K31/167 , A61K47/10 , A61K51/1258
摘要： The present disclosure provides an extended release pharmaceutical composition comprising hydrocodone and acetaminophen that provides a rapid onset of analgesia, and reduced levels of acetaminophen near the end of the dosing interval. Also provided are methods for reducing the risk of acetaminophen-induced hepatic damage in a subject being treated with an acetaminophen containing composition, as well as methods for treating pain in a subject in need thereof.
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2.发明申请COMBINATION COMPOSITION COMPRISING OXYCODONE AND ACETAMINOPHEN FOR RAPID ONSET AND EXTENDED DURATION OF ANALGESIA 有权包含氧化钙和乙酰氨基酚的组合组合物用于快速延长和延长的治疗时间公开(公告)号：US20150164808A1
公开(公告)日：2015-06-18
申请号：US14627879
申请日：2015-02-20
申请人： MALLINCKRODT LLC
发明人： KRISHNA R. DEVARAKONDA , MICHAEL J. GIULIANI , VISHAL K. GUPTA , RALPH A. HEASLEY , SUSAN SHELBY
IPC分类号： A61K9/24 , A61K31/485 , A61K31/167
CPC分类号： A61K31/485 , A61K9/0053 , A61K9/2013 , A61K9/2031 , A61K9/2054 , A61K9/2086 , A61K9/209 , A61K31/167 , A61K47/10 , A61K2300/00
摘要： The present disclosure provides an extended release pharmaceutical composition comprising oxycodone and acetaminophen that provides a rapid onset of analgesia, and reduced levels of acetaminophen near the end of the dosing interval. Also provided are methods for reducing the risk of acetaminophen-induced hepatic damage in a subject being treated with an acetaminophen containing composition, as well as methods for treating pain in a subject in need thereof.
摘要翻译： 本公开提供了包含羟考酮和对乙酰氨基酚的延长释放药物组合物，其提供了止痛剂的快速开始，并且在给药间隔结束时附近降低了对乙酰氨基酚的水平。 还提供了降低用含对乙酰氨基酚组合物治疗的受试者中对乙酰氨基酚诱发的肝损伤风险的方法，以及用于治疗有需要的受试者的疼痛的方法。
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公开(公告)号：US20160243041A1
公开(公告)日：2016-08-25
申请号：US15147621
申请日：2016-05-05
申请人： MALLINCKRODT LLC
发明人： KRISHNA R. DEVARAKONDA , MICHAEL J. GIULIANI , VISHAL K. GUPTA , RALPH A. HEASLEY , SUSAN SHELBY
IPC分类号： A61K9/24 , A61K31/485 , A61K9/20 , A61K31/167
CPC分类号： A61K9/2031 , A61K9/0065 , A61K9/209 , A61K31/167 , A61K31/485 , A61K47/34 , A61K2300/00
摘要： The present disclosure provides extended release pharmaceutical compositions comprising an opioid and an additional active pharmaceutical ingredient, wherein the composition exhibits gastric retentive properties which are achieved by a combination of a physical property of the composition and release of the opioid, wherein upon administration to a subject, the composition has at least one pharmacokinetic parameter that differs by less than about 30% when the subject is in a fasted state as compared to a fed state.
摘要翻译： 本公开提供了包含阿片样物质和另外的活性药物成分的延长释放药物组合物，其中所述组合物显示出通过组合物的物理性质和阿片样物质的释放的组合来实现的胃保持性质，其中在施用于受试者 当与进食状态相比，当受试者处于禁食状态时，该组合物具有至少一个药代动力学参数差异小于约30％。
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4.发明申请Tamper Resistant Composition Comprising Hydrocodone And Acetaminophen For Rapid Onset And Extended Duration Of Analgesia 有权包含氢可酮和对乙酰氨基酚的抗鞣剂组合物用于快速起始和延长的止痛持续时间公开(公告)号：US20140378498A1
公开(公告)日：2014-12-25
申请号：US14479129
申请日：2014-09-05
申请人： MALLINCKRODT LLC
IPC分类号： A61K47/10 , A61K31/167 , A61K31/485
CPC分类号： A61K31/485 , A61K9/0053 , A61K9/2031 , A61K9/2086 , A61K9/209 , A61K31/167 , A61K47/10 , A61K51/1258
摘要： The present disclosure provides an extended release pharmaceutical composition comprising hydrocodone and acetaminophen that provides a rapid onset of analgesia, and reduced levels of acetaminophen near the end of the dosing interval. Also provided are methods for reducing the risk of acetaminophen-induced hepatic damage in a subject being treated with an acetaminophen containing composition, as well as methods for treating pain in a subject in need thereof.
摘要翻译： 本公开内容提供了包含氢可酮和对乙酰氨基酚的延长释放药物组合物，其在给药间隔结束附近提供快速起搏镇痛和降低的对乙酰氨基酚水平。 还提供了降低用含对乙酰氨基酚组合物治疗的受试者中对乙酰氨基酚诱发的肝损伤风险的方法，以及用于治疗有需要的受试者的疼痛的方法。
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5.发明申请公开(公告)号：US20160184299A1
公开(公告)日：2016-06-30
申请号：US15065635
申请日：2016-03-09
申请人： MALLINCKRODT LLC
发明人： KRISHNA R. DEVARAKONDA , MICHAEL J. GIULIANI , VISHAL K. GUPTA , RALPH A. HEASLEY , SUSAN SHELBY
IPC分类号： A61K31/485 , A61K47/10 , A61K9/00 , A61K31/167
CPC分类号： A61K31/485 , A61K9/0053 , A61K9/2013 , A61K9/2031 , A61K9/2054 , A61K9/2086 , A61K9/209 , A61K31/167 , A61K47/10 , A61K2300/00
摘要： The present disclosure provides an extended release pharmaceutical composition comprising oxycodone and acetaminophen that provides a rapid onset of analgesia, and reduced levels of acetaminophen near the end of the dosing interval. Also provided are methods for reducing the risk of acetaminophen-induced hepatic damage in a subject being treated with an acetaminophen containing composition, as well as methods for treating pain in a subject in need thereof.
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公开(公告)号：US20140105977A1
公开(公告)日：2014-04-17
申请号：US14132500
申请日：2013-12-18
申请人： MALLINCKRODT LLC
发明人： KRISHNA R. DEVARAKONDA , MICHAEL J. GIULIANI , VISHAL K. GUPTA , RALPH A. HEASLEY , SUSAN SHELBY
IPC分类号： A61K31/485 , A61K9/24 , A61K47/34 , A61K31/167
CPC分类号： A61K9/2031 , A61K9/0065 , A61K9/209 , A61K31/167 , A61K31/485 , A61K47/34 , A61K2300/00
摘要： The present disclosure provides extended release pharmaceutical compositions comprising an opioid and an additional active pharmaceutical ingredient, wherein the composition exhibits gastric retentive properties which are achieved by a combination of a physical property of the composition and release of the opioid, wherein upon administration to a subject, the composition has at least one pharmacokinetic parameter that differs by less than about 30% when the subject is in a fasted state as compared to a fed state.
摘要翻译： 本公开提供了包含阿片样物质和另外的活性药物成分的延长释放药物组合物，其中所述组合物显示出通过组合物的物理性质和阿片样物质的释放的组合来实现的胃保持性质，其中在施用于受试者 当与进食状态相比，当受试者处于禁食状态时，该组合物具有至少一个药代动力学参数差异小于约30％。
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