公开(公告)号：US11021507B2

公开(公告)日：2021-06-01

申请号：US16324679

申请日：2017-08-04

申请人： MARINE BIOMEDICAL RESEARCH INSTITUTE OF QINGDAO CO., LTD.

发明人： Wenbao Li ,  Xianjun Qu ,  Feng Li ,  Liang Zhang ,  Shixiao Wang ,  Zhiyu Song ,  Feng Wang ,  Chong Yang ,  Huashi Guan

IPC分类号： C07H17/07 ,  A61K31/7048 ,  A61P35/00 ,  A61P1/00 ,  A61P1/04 ,  C07D311/64 ,  C07H1/00

摘要： The present invention provides a myricetin derivative, a preparation method thereof, a pharmaceutical composition containing the same, an application thereof for treating colitis, preventing and treating colitis-associated tumorigenesis and treating colorectal cancer, and an application thereof in preparing a composition for modulating activities of endoplasmic reticulum stress signaling molecules. The myricetin derivative disclosed herein has excellent water solubility, and has biological activities including inhibition of colitis, prevention and treatment of colitis-associated tumorigenesis, and treatment of colorectal cancer. The preparation method disclosed herein uses myricetrin as starting material which is economical and easily available. With the merits of low cost, high yield, high product purity and suitability for large-scale industrial production, the preparation method disclosed herein represents significant market value and economic prospects.