公开(公告)号：US09913854B2

公开(公告)日：2018-03-13

申请号：US14388685

申请日：2013-03-14

申请人： MASSACHUSETTS EYE & EAR INFIRMARY

发明人： Michael S. Gilmore ,  Takashi Suzuki

IPC分类号： A61K31/706 ,  A61K31/655 ,  A01N43/54 ,  A01N33/26 ,  C07D405/14 ,  C09B23/14 ,  C09B29/01 ,  C09B29/095 ,  C09B31/043 ,  C09B33/056 ,  C09B33/16 ,  C09B67/36 ,  C09B67/02 ,  A61K45/06 ,  A61K31/7072

CPC分类号： A61K31/706 ,  A01N33/26 ,  A01N43/54 ,  A61K31/655 ,  A61K31/7072 ,  A61K45/06 ,  C07D405/14 ,  C09B23/148 ,  C09B29/0014 ,  C09B29/0955 ,  C09B31/043 ,  C09B33/056 ,  C09B33/16 ,  C09B67/0079 ,  C09B67/0097 ,  A61K2300/00

摘要： Provided herein are methods for inducing cell death in a gram positive bacterium and methods for reducing the proliferation of a gram positive bacterium that include contacting a gram positive bacterium with a dye (e.g., an azo dye) and a TarO inhibitor. Also provided are methods of treating a subject having a gram positive bacterial infection that include administering to a subject having a gram positive bacterial infection a dye (e.g., an azo dye) and a TarO inhibitor. Also provided are compositions containing a dye (e.g., an azo dye) and a TarO inhibitor, and kits containing at least one of these compositions.

公开(公告)号：US10420826B2

公开(公告)日：2019-09-24

申请号：US15524576

申请日：2015-11-10

申请人： Massachusetts Eye & Ear Infirmary

发明人： Michael Valentino ,  Michael S. Gilmore

IPC分类号： C07K14/315 ,  A61K39/09

摘要： Compositions comprising antigenic peptides, and their use in inducing an immunoprotective response in a subject against an infection with Streptococcus pneumonia, or for treating or preventing, i.e., reducing risk of, an infection of Streptococcus pneumonia.

公开(公告)号：US20180271968A1

公开(公告)日：2018-09-27

申请号：US15524576

申请日：2015-11-10

申请人： Massachusetts Eye & Ear Infirmary

发明人： Michael Valentino ,  Michael S. Gilmore

IPC分类号： A61K39/09

摘要： Compositions comprising antigenic peptides, and their use in inducing an immunoprotective response in a subject against an infection with Streptococcus pneumonia, or for treating or preventing, i.e., reducing risk of, an infection of Streptococcus pneumonia.

公开(公告)号：US20150087614A1

公开(公告)日：2015-03-26

申请号：US14388685

申请日：2013-03-14

申请人： MASSACHUSETTS EYE & EAR INFIRMARY

发明人： Michael S. Gilmore ,  Takashi Suzuki

IPC分类号： A61K31/706 ,  A01N43/54 ,  A01N33/26 ,  A61K31/655

CPC分类号： A61K31/706 ,  A01N33/26 ,  A01N43/54 ,  A61K31/655 ,  A61K31/7072 ,  A61K45/06 ,  C07D405/14 ,  C09B23/148 ,  C09B29/0014 ,  C09B29/0955 ,  C09B31/043 ,  C09B33/056 ,  C09B33/16 ,  C09B67/0079 ,  C09B67/0097 ,  A61K2300/00

摘要： Provided herein are methods for inducing cell death in a gram positive bacterium and methods for reducing the proliferation of a gram positive bacterium that include contacting a gram positive bacterium with a dye (e.g., an azo dye) and a TarO inhibitor. Also provided are methods of treating a subject having a gram positive bacterial infection that include administering to a subject having a gram positive bacterial infection a dye (e.g., an azo dye) and a TarO inhibitor. Also provided are compositions containing a dye (e.g., an azo dye) and a TarO inhibitor, and kits containing at least one of these compositions.

摘要翻译： 本文提供了用于在革兰氏阳性细菌中诱导细胞死亡的方法和用于减少革兰氏阳性细菌增殖的方法，其包括使革兰氏阳性细菌与染料（例如偶氮染料）和TarO抑制剂接触。 还提供了治疗具有革兰氏阳性细菌感染的受试者的方法，其包括向具有革兰氏阳性细菌感染的受试者施用染料（例如偶氮染料）和TarO抑制剂。 还提供了含有染料（例如偶氮染料）和TarO抑制剂的组合物和含有这些组合物中的至少一种的试剂盒。