专利检索 ap:("MASSACHUSETTS INSTITUTE OF TECHNOLOGY" OR "WHITEHEAD INSTITUTE OF BIOMEDICAL RESEARCH") AND inv:"STEPHEN LEFFLER BUCHWALD" 第 1 页

1.

发明公开
SYNTHESIS OF COVALENT PROTEIN DIMERS THAT CAN INHIBIT MYC-DRIVEN TRANSCRIPTION 审中-公开

公开(公告)号：US20240336649A1

公开(公告)日：2024-10-10

申请号：US18572247

申请日：2022-06-17

申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , WHITEHEAD INSTITUTE OF BIOMEDICAL RESEARCH

发明人： ANDREI LOAS , BRADLEY L. PENTELUTE , SEBASTIAN POMPLUN , MUHAMMAD JBARA , CARLY KATHERINE SCHISSEL , JACOB JOSHUA LEE RODRIQUEZ , STEPHEN LEFFLER BUCHWALD , ANN BOIJA , ISAAC KLEIN , SUSANA WILSON HAWKEN , CHARLES HAN LI

IPC分类号： C07K1/10 , A61K38/00 , A61K49/00 , A61P35/00 , C07K1/06 , C07K1/107 , C07K14/00

CPC分类号： C07K1/10 , A61K49/0041 , A61K49/0056 , A61P35/00 , C07K1/063 , C07K1/1075 , C07K14/00 , A61K38/00

摘要： The disclosure relates to covalent protein dimers of MYC, MAX, and Omomyc; pharmaceutical compositions comprising the covalent protein dimers; methods of making the covalent protein dimers; and methods of treating disorders associated with MYC dysregulation (e.g., cancer) with the covalent protein dimers.