公开(公告)号：US20240294455A1

公开(公告)日：2024-09-05

申请号：US18571275

申请日：2022-06-16

申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E. V.

发明人： Stefan GLÖGGLER ,  Sergey KORCHAK ,  Anil P. JATAP ,  Philip SAUL ,  Denis MOLL

IPC分类号： C07C67/31 ,  C07B59/00 ,  C07C67/307 ,  C07C67/317 ,  C07C69/63 ,  C07C69/732 ,  C07C201/12 ,  C07C205/34 ,  C07C227/18 ,  C07C229/08

CPC分类号： C07C67/31 ,  C07B59/001 ,  C07C67/307 ,  C07C67/317 ,  C07C69/63 ,  C07C69/732 ,  C07C201/12 ,  C07C205/34 ,  C07C227/18 ,  C07C229/08 ,  C07B2200/05

摘要： The present invention relates to a method for preparing a compound suitable for signal enhanced magnetic resonance imaging comprising the steps of vinylating a mono-, di- or tricarboxylic acid comprising a moiety -Q-Z with Q being O or N and Z being a protecting group by using vinyl acetate, cleaving Z, and if Z has not already been converted into an alcohol upon cleavage, converting Q into an alcohol either by using nitrite or by converting Q into bromine followed by hydrolysis yielding a vinyl hydroxy ester. The compounds used may be partly or fully deuterated. Furthermore, the present invention relates to a vinyl hydroxy ester as well as an intermediate of its synthesis, wherein the vinyl moiety of the vinyl hydroxy ester and of the intermediate is partly or fully deuterated.