公开(公告)号：US20160081960A1

公开(公告)日：2016-03-24

申请号：US14888764

申请日：2014-05-07

Applicant: MCMASTER UNIVERSITY

Inventor： Gerry Wright ,  Wenliang Wang ,  Andrew King

IPC: A61K31/198 ,  A61K31/407 ,  A61K45/06

CPC classification number: A61K31/198 ,  A61K31/407 ,  A61K31/4196 ,  A61K45/06 ,  Y02A50/473

Abstract: The present application relates to combination treatments for bacterial infections. For example, the application relates to the use of one or more β-lactam antibiotics and one or more compounds of Formula I: (I) for treatment of a metallo-B-lactamase-expressing bacterial infection or a disease, disorder or condition arising from a metallo-B-lactamase-expressing bacterial infection.

Abstract translation: 本申请涉及细菌感染的组合治疗。 例如，本申请涉及使用一种或多种β-内酰胺抗生素和一种或多种式I化合物：（I）用于治疗表达金属-β-内酰胺酶的细菌感染或疾病，病症或病症 由表达金属B-内酰胺酶的细菌感染引起。

公开(公告)号：US20180296517A1

公开(公告)日：2018-10-18

申请号：US16014167

申请日：2018-06-21

Applicant: McMaster University

Inventor： Gerry Wright ,  Wenliang Wang ,  Andrew King

IPC: A61K31/198 ,  A61K45/06 ,  A61K31/407 ,  A61K31/4196

Abstract: The present application relates to combination treatments for bacterial infections. For example, the application relates to the use of one or more β-lactam antibiotics and one or more compounds of Formula I: (I) for treatment of a metallo-β-lactamase-expressing bacterial infection or a disease, disorder or condition arising from a metallo-β-lactamase-expressing bacterial infection.

公开(公告)号：US10016383B2

公开(公告)日：2018-07-10

申请号：US14888764

申请日：2014-05-07

Applicant: McMaster University

Inventor： Gerry Wright ,  Wenliang Wang ,  Andrew King

IPC: A61K31/198 ,  A61K31/407 ,  A61K31/4196 ,  A61K45/06

CPC classification number: A61K31/198 ,  A61K31/407 ,  A61K31/4196 ,  A61K45/06 ,  Y02A50/473

Abstract: The present application relates to combination treatments for bacterial infections. For example, the application relates to the use of one or more β-lactam antibiotics and one or more compounds of Formula I: (I) for treatment of a metallo-B-lactamase-expressing bacterial infection or a disease, disorder or condition arising from a metallo-B-lactamase-expressing bacterial infection.