公开(公告)号：US20250120187A1

公开(公告)日：2025-04-10

申请号：US18480985

申请日：2023-10-04

Applicant: GM Global Technology Operations LLC ,  McMaster University

Inventor： Taeyoung HAN ,  Shyh-yeu JAO ,  Valerie Sue MALANEY ,  Yujie GUO ,  Ian J. SUTHERLAND ,  Rafael KLEIMAN ,  Manoj VISHWAKARMA ,  Jennifer BAUMAN

IPC: H01L31/049 ,  B60L8/00

Abstract: A vehicle part with at least one integrated photovoltaic element includes a part body, at least one area of a barrier layer disposed on at least a portion of the surface of the part body; and at least one photovoltaic element disposed over an area of the barrier layer. Paint covers the portions of the surface of the part body surrounding the photovoltaic elements. A method of making a vehicle part having at least one integrated photovoltaic element includes applying at least one area of a barrier layer on at least a portion of the surface of the part and applying at least one photovoltaic element over an area of the barrier layer. A protective layer is applied over the surface of the photovoltaic element, the surface of the part is painted, and the protective layer can then be removed to expose the photovoltaic element.

公开(公告)号：US20250055378A1

公开(公告)日：2025-02-13

申请号：US18231887

申请日：2023-08-09

Applicant: McMaster University

Inventor： Ahmed Elezab ,  Omar Zayed ,  Mehdi Narimani

IPC: H02M3/335 ,  H02M3/00

Abstract: Systems and methods for providing DC-DC power converter topologies are described. In at least one embodiment, a DC-DC power converter comprises a primary sub-circuit coupled to a fixed or variable DC input voltage, a first secondary sub-circuit and a second secondary sub-circuit, a transformer isolating the primary sub-circuit from the first and the second secondary sub-circuits, the transformer comprising a predetermined number of turns, the first and the second secondary sub-circuits being configurable in a series mode and a parallel mode by switching configurations of a first, second and third transition switch, and the first and the second secondary sub-circuits providing an output charging voltage and an output charging current for charging an external device.

公开(公告)号：US20250044307A1

公开(公告)日：2025-02-06

申请号：US18713411

申请日：2022-11-25

Applicant: McMaster University

Inventor： Peter Kavsak ,  Lorna Clark

IPC: G01N33/96

Abstract: A method for the preparation of a cardiac troponin quality control sample of a mammal to determine the accuracy and/or precision of a cardiac troponin assay over time is provided. The method comprises the steps of: i) preparing a cardiac troponin concentrate from a pool of biological samples obtained from a population of the mammal having a troponin concentration of greater than 75% of an upper analytical limit of the assay; ii) obtaining a cardiac troponin base material comprising whole blood, plasma or serum of the mammal which is interference-free and disease-free; and iii) combining a quantity of the troponin concentrate with the base material to yield a quality control sample having a target concentration. Quality control samples may be provided in kits which provide a set of samples having particular concentrations which essentially correspond with lower detectable limits of an assay, upper limits of normal, as well as concentrations which define risk stratification cutoffs and other diagnostic cutoffs.

公开(公告)号：US20250011413A1

公开(公告)日：2025-01-09

申请号：US18706314

申请日：2022-11-03

Applicant: McMaster University

Inventor： Ishac Nazy ,  John Kelton ,  Donald Arnold ,  Anna-Lise Bissola ,  Colin Kretz

IPC: C07K16/24 ,  A61K39/00 ,  A61P7/02 ,  G01N33/564 ,  G01N33/68

Abstract: Provided herein are wildtype and mutant single chain variable fragments (scFvs) of the anti-PF4/heparin monoclonal antibody KKO, and variants thereof which are useful for distinguishing between platelet-activating (pathogenic) and non-activating (non-pathogenic) anti-PF4/heparin antibodies. Also provided herein are uses of the scFvs in methods for identifying patients with pathogenic anti-PF4/heparin antibodies, and for diagnosing and treating heparin-induced thrombocytopenia (HIT).

公开(公告)号：US20240359211A1

公开(公告)日：2024-10-31

申请号：US18768186

申请日：2024-07-10

Applicant: McMaster University

Inventor： Leyla Soleymani ,  Roderick Maclachlan ,  Sara Moetakef Imani ,  Yuting Chan ,  Tohid Didar

IPC: B05D5/08 ,  B05D3/02 ,  B05D3/06

CPC classification number: B05D5/083 ,  B05D3/0254 ,  B05D3/066 ,  B05D2506/10 ,  B05D2518/10

Abstract: This application relates to omniphobic materials which are physically and chemically modified at their surface to create hierarchically structured materials with both nanoscale and microscale structures that provide the omniphobic properties. Methods of making such omniphobic surfaces with hierarchical structures and uses thereof, including as flexible films that repel contaminants are also disclosed in the application.

公开(公告)号：US20240263163A1

公开(公告)日：2024-08-08

申请号：US18565957

申请日：2022-06-01

Applicant: McMaster University

Inventor： Tamaghna Gupta ,  Rakesh P. Sahu ,  Ishwar K. Puri

IPC: C12N13/00 ,  C12M1/32 ,  C12M1/42 ,  C12N5/071

CPC classification number: C12N13/00 ,  C12M23/12 ,  C12M35/06 ,  C12N5/0688 ,  C12N2529/00 ,  C12N2533/90

Abstract: This application relates to methods of generating cell/particle-free regions in a cellular/particle aggregate using label-free magnetic manipulation. For example, the method may include suspending cells/particles in a paramagnetic culture medium, the cells/particles being diamagnetic; seeding the cells/particles and the paramagnetic culture medium into microwells; and placing the microwells over an array of magnet pairs where each magnet pair creates a magnetic field gradient. The magnetic susceptibility difference and the magnetic field gradient drive the cells/particles towards a spaced region between magnets in the magnet pair having a lowest magnetic field strength to create a cell/particle aggregate with a cell-free/particle-free area where the cell/particle aggregate surrounds the cell-free/particle-free area.

公开(公告)号：US12030043B2

公开(公告)日：2024-07-09

申请号：US17620392

申请日：2020-06-19

Applicant: MCMASTER UNIVERSITY

Inventor： Leyla Soleymani ,  Igor Zhitomirsky ,  Amanda Victorious ,  Amanda Clifford

IPC: B01J35/39 ,  B01J21/06 ,  B01J31/06 ,  B01J35/23

CPC classification number: B01J35/39 ,  B01J21/063 ,  B01J31/062 ,  B01J35/23

Abstract: This application relates to a photoactive product comprising: a catechol-containing compound, an amine-containing polymer, and photoactive material. The photoactive product can act as a photocatalyst and can be used in photoelectrodes for use in, for example, photoelectrochemical analyte sensing, including biosensing. The photoelectrodes modified with hybrid organic/inorganic materials can provide increased light absorption and charge separation, binding sites for attaching biorecognition probes, and built-in film-forming properties for well-adhered and uniform photoactive frameworks on the collector electrodes.

公开(公告)号：US20240223097A1

公开(公告)日：2024-07-04

申请号：US18541124

申请日：2023-12-15

Applicant: McMaster University

Inventor： Omar Zayed ,  Ahmed Elezab ,  Mehdi Narimani

IPC: H02M3/335 ,  B60L53/22 ,  H02J7/02 ,  H02M1/00

CPC classification number: H02M3/33584 ,  B60L53/22 ,  H02J7/02 ,  H02M1/007 ,  H02M3/33573 ,  B60L2210/10

Abstract: A dual-active bridge (DAB) converter is provided. The DAB converter comprises a primary sub-circuit coupled to a direct-current (DC) input voltage, a first secondary sub-circuit and a second secondary sub-circuit, and a transformer isolating the primary sub-circuit from the first and the second secondary sub-circuits and comprising a predetermined number of turns. Each of the first and the secondary sub-circuits comprise a corresponding inductor; the first and the second secondary sub-circuits being configurable in a series mode and a parallel mode by switching configurations of a first, second and third transition switch; and the first and the second secondary sub-circuits providing an output charging voltage and an output charging current for charging an external device. A charging station comprising one or more charging poles, with each charging pole comprising one of more DAB converters is also disclosed.

公开(公告)号：US20240200172A1

公开(公告)日：2024-06-20

申请号：US18288467

申请日：2022-04-21

Applicant: Nemak, S.A.B. de C.V. ,  McMaster University

Inventor： Glenn Edwin Byczynski ,  Anthony Marco Lombardi ,  Sumanth Shankar ,  Xiaochun Zeng

IPC: C22C21/10 ,  B22D21/00 ,  C22C1/02 ,  C22F1/053

CPC classification number: C22C21/10 ,  B22D21/007 ,  C22C1/026 ,  C22F1/053

Abstract: An aluminum casting alloy for near net shaped casting of structural or non-structural components containing, in % by mass, Zn: 4.5-7.5%, Mg: 0.7-2.0%, Fe: 0.8-2.0%, Si:

公开(公告)号：US12011422B2

公开(公告)日：2024-06-18

申请号：US17826770

申请日：2022-05-27

Applicant: McMaster University

Inventor： Eric Brown ,  Omar M Elhalfawy ,  Nick Jentsch ,  Xiong Zhang ,  Jakob Magolan

IPC: A61K31/055 ,  A61K31/05 ,  A61K31/11 ,  A61K31/121 ,  A61K31/341 ,  A61K31/381 ,  A61K31/42 ,  A61K31/4418 ,  A61K31/47 ,  A61K31/505 ,  A61K38/12 ,  A61P31/04 ,  C07C39/19 ,  C07C43/275 ,  C07C49/78 ,  C07C205/18 ,  C07D213/30 ,  C07D215/14 ,  C07D239/26 ,  C07D239/42 ,  C07D261/08 ,  C07D307/48 ,  C07D333/38

CPC classification number: A61K31/055 ,  A61K31/05 ,  A61K31/11 ,  A61K31/121 ,  A61K31/341 ,  A61K31/381 ,  A61K31/42 ,  A61K31/4418 ,  A61K31/47 ,  A61K31/505 ,  A61K38/12 ,  A61P31/04 ,  C07C39/19 ,  C07C43/275 ,  C07C49/78 ,  C07C205/18 ,  C07D213/30 ,  C07D215/14 ,  C07D239/26 ,  C07D239/42 ,  C07D261/08 ,  C07D307/48 ,  C07D333/38

Abstract: Provided herein are novel synthetic compounds having the structure of formula (1),




wherein X is a substituted or unsubstituted aromatic or heteroaromatic mono- or polycyclic ring system; and Y is substituted or unsubstituted C5-C10 alkyl or alkenyl group, or a pharmaceutically acceptable salt thereof. Also provided are pharmaceutical compositions. The compounds and pharmaceutical compositions are useful for inhibiting growth of a bacterium.