公开(公告)号：US20240299577A1

公开(公告)日：2024-09-12

申请号：US18275323

申请日：2022-01-28

申请人： MDIMUNE INC.

发明人： Shin Gyu BAE ,  Seung Wook OH ,  Jung Eun PARK ,  Sung Soo PARK ,  Ye Rim KWON ,  Hui Chong LAU ,  Jin Hee PARK

IPC分类号： A61K47/69 ,  A61K35/22 ,  A61K35/28

CPC分类号： A61K47/6901 ,  A61K35/22 ,  A61K35/28

摘要： The present invention relates to cell-derived vesicles with increased cellular uptake capacity and a method for producing same. The cell-derived vesicles of the present invention are produced by migrating cells to micropores, and exhibit the characteristic of expressing a protein marker that is different from that of exosomes naturally secreted by cells. The cell-derived vesicles with increased cellular uptake capacity, according to the present invention, have remarkably superior cellular uptake capacity as compared to natural exosomes secreted by cells, and thus can be effectively used to deliver various active substances, such as drugs and marker substances, into target cells.