公开(公告)号：US3902849A

公开(公告)日：1975-09-02

申请号：US38379773

申请日：1973-07-30

Applicant: MEDI PHYSICS INC

Inventor： BARAK MORTON ,  WINCHELL HARRY W

IPC: A61K51/12 ,  G01N30/52 ,  G01N30/60 ,  A61K27/04 ,  B01D59/30 ,  B01J1/00

CPC classification number: G01N30/6091 ,  A61K51/1282 ,  A61K2123/00 ,  G01N30/52 ,  G01N30/603 ,  G01N30/6034

Abstract: A chromatographic column for generating technetium-99m isotopes and technetium-99m labeled pharmaceuticals in a simple two-step process. Technetium-99m pertechnetate in a first step is isolated by adsorption upon an adsorbent packing. Then the technetium-99m in a second step is eluted from the packing, either with an immediately labeled biological compound to form a radiopharmaceutical, or by a controlled volume of eluant to produce a 99m-technetium-bearing eluate of a desired specific concentration.

Abstract translation: 一种用于以简单的两步法生成锝-99m同位素和锝-99m标记药物的色谱柱。 锝-99m高锝酸盐在第一步通过吸附填料分离。 然后第二步中的锝-99m从包装中用立即标记的生物化合物洗脱以形成放射性药物，或通过受控体积的洗脱液洗脱，以产生具有所需特定浓度的99m-含锝的洗脱液。

公开(公告)号：US3875299A

公开(公告)日：1975-04-01

申请号：US25073872

申请日：1972-05-05

Applicant: MEDI PHYSICS INC

Inventor： WINCHELL HARRY S ,  BARAK MORTON ,  VAN FLEET III PARMER

IPC: A61K51/00 ,  A61K51/12 ,  A61K27/04

CPC classification number: A61K51/1217 ,  A61K2123/00

Abstract: An improved 99m- technetium labeled tin(II) colloid, size stabilized for reticuloendothelial organ imaging without the use of macromolecular stabilizers and a packaged tin base reagent and improved method for making it.

Abstract translation: 改进的99m-锝标记的锡（II）胶体，尺寸稳定的网状内皮细胞成像，不使用大分子稳定剂和包装的锡碱试剂和改进的制备方法。