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公开(公告)号：US11867670B2
公开(公告)日：2024-01-09
申请号：US16963784
申请日：2019-01-22
CPC分类号： G01N30/52 , B01D15/1871 , G01N30/603 , G01N2030/386
摘要： Disclosed is a continuous process in which a subset of a number of mutually identical columns, are connected in series. The process liquid, e.g. crude cell culture harvest, is supplied to the most upstream column of the subset. It flows successively through the in series connected columns and leaves the subset through the most downstream and flows into the downstream collection vessel. As soon as the packed bed of the most upstream column is become saturated with product, this column is disconnected from the subset. It is removed from the series connection. A replacement, identical, column is added such that it is connected in series downstream from the most downstream column of the subset. This process is repeated.
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公开(公告)号：US20180238842A1
公开(公告)日：2018-08-23
申请号：US15752322
申请日：2016-08-23
申请人： SHOWA DENKO K.K.
发明人： Junya KATO , Hideyuki KONDO , Naoko MARUOKA , Anne RIESS
CPC分类号： G01N30/6052 , B01D15/22 , B01J20/265 , B01J20/285 , G01N30/56 , G01N30/603 , G01N30/88 , G01N2030/524
摘要： A liquid chromatographic column includes: a cylindrical column body; an inflow-side filter that is disposed at an eluent inflow-side end of the column body; an outflow-side filter that is disposed at an eluent outflow-side end of the column body; and a filler that is filled between the inflow-side filter and the outflow-side filter, in which the inflow-side filter has a two-layer structure consisting of a first resin filter member and a second resin filter member which are disposed in this order from a side of the filler, and the first resin filter member has an indentation elastic modulus lower than that of the second resin filter member.
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公开(公告)号：US20170333957A1
公开(公告)日：2017-11-23
申请号：US15526537
申请日：2015-11-25
CPC分类号： B08B9/0321 , B01D15/22 , G01L13/00 , G01N30/603 , G01N30/6052
摘要： The invention discloses a method for individually assessing the cleanness of at least one of an upper (2) and a lower (3) bed support in a process column (1). The method comprises the steps of: a) providing a process column (1) comprising an upper (2) and a lower (3) bed support, a column chamber, a movable adaptor (5), an upper outlet (6) and a lower outlet (7); b) conveying liquid through one of the lower (3) and upper (2) bed supports, e.g. by moving the adaptor (5) downwards at a predetermined rate with one of the upper and lower outlets closed and the other open to force liquid through one of the lower and upper bed supports, and; c) measuring the differential pressure over the bed support through which liquid passes.
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公开(公告)号：US09764323B2
公开(公告)日：2017-09-19
申请号：US14489855
申请日：2014-09-18
CPC分类号： B01L3/502753 , B01L3/502707 , B01L3/502715 , B01L3/502746 , B01L2200/027 , B01L2300/0681 , B01L2400/0487 , B01L2400/086 , G01N30/603 , G01N30/6095
摘要： A system that incorporates teachings of the subject disclosure may include, for example, a process that includes obtaining a porous medium comprising a porous material having a first shape and an initial porosity profile. The porous medium is engaged with a cavity in a fluidic device, wherein the cavity is in fluid communication with a channel of the fluidic device. The first shape of the porous material can be adjusted to a second shape resulting in the initial porosity profile being adjusted to a target porosity profile. Such adjustment can be accomplished by the engaging of the porous medium with the cavity, by pre-adjusting a shape of the porous media before insertion into the cavity, or by some combination thereof. Other embodiments are disclosed.
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公开(公告)号：US20160214031A1
公开(公告)日：2016-07-28
申请号：US15006647
申请日：2016-01-26
CPC分类号： B01D15/22 , G01N30/603 , G01N30/6069
摘要： The current invention is directed to a chromatography column separator which separates the chromatography column in an upper chromatography column chamber and a lower chromatography column chamber, and which has a variable position within the chromatography column, and which is embedded by the chromatography material. The separator allows the replacement of the chromatography material in the upper chromatography column chamber without the need to replace the chromatography column material in the lower chromatography column chamber and it allows also the combination of two different chromatography materials with different chromatographical functional groups in one chromatography column.
摘要翻译： 本发明涉及一种色谱柱分离器，其在上层色谱柱室和较低色谱柱室中分离色谱柱，并且在色谱柱内具有可变位置，并且被色谱材料包埋。 分离器允许在上层色谱柱室中更换色谱材料，而不需要更换下层色谱柱室中的色谱柱材料，并且还允许在一个色谱柱中组合具有不同色谱官能团的两种不同色谱材料 。
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公开(公告)号：US20160206972A1
公开(公告)日：2016-07-21
申请号：US15067694
申请日：2016-03-11
发明人： Sébastien Lefebvre , Lilian Portier , Maurice Agée
CPC分类号： B01D15/22 , B01D15/206 , B65B1/24 , F16L11/00 , F16L33/00 , G01N30/56 , G01N30/6021 , G01N30/603 , G01N30/6082 , G01N2030/565 , Y10T29/49865
摘要： A chromatography column design and a packing device, as well as a method for obtaining a column with a very compact and uniform bed are provided. The bed remains compact and uniform during operation of the column and during sanitization, storage and transportation of the column. The amount of hardware, particularly the hardware parts in contact with product, is minimized, especially with the implementation of an internal liner. With this internal liner, the packed bed can be separated from the column in intact form, or even prepared separately from, and outside of, the column.
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7.发明授权Robust and low backpressure on-column tunneled frit for nano-UPLC-MS applications 有权用于纳米UPLC-MS应用的坚固和低背压柱上隧道玻璃料公开(公告)号：US09267927B2
公开(公告)日：2016-02-23
申请号：US13112519
申请日：2011-05-20
申请人： Chao-Jung Chen , Mei-Chun Tseng , Yet-Ran Chen
发明人： Chao-Jung Chen , Mei-Chun Tseng , Yet-Ran Chen
CPC分类号： G01N30/603 , B01D15/22 , G01N30/6078
摘要： A durable on-column tunneled frit was developed for use in nanoflow UPLC systems. The frit was tunneled during sol-gel reaction. The tunneled-frit fabrication process is easy and reproducible in terms of back pressure and durability. This design creates low backpressure with high liquid flow, which is suitable for the nanoflowUPLC application. A short packing (2 cm C18 particle) tunneled-frit column was demonstrated to sustain 10,000 psi continuous liquid flow for over one week without any particle leakage or pressure instability. The tunneled-frit was also successfully applied to the fabrication of nanoUPLC trapping and analytical column system. It was demonstrated to have high separation efficiency and sensitivity for the analysis of tryptic peptides as well as improved detection sensitivity for phosphopeptide analysis.
摘要翻译： 开发了一种耐用的柱内隧道玻璃料，用于纳流低压UPLC系统。 玻璃料在溶胶 - 凝胶反应过程中被隧道化。 隧道式玻璃料制造工艺在背压和耐久性方面是容易的和可再现的。 该设计产生低液压，具有高液体流量，适用于纳米FLUP应用。 证明短填料（2cm C18颗粒）隧道玻璃料柱能够持续10,000psi连续液流超过一周，没有任何颗粒泄漏或压力不稳定性。 隧道玻璃料也成功应用于nanoUPLC捕集和分析柱系统的制造。 已被证明具有高分离效率和敏感性，用于分析胰蛋白酶肽，以及提高磷酸肽分析的检测灵敏度。
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公开(公告)号：US20150338383A1
公开(公告)日：2015-11-26
申请号：US14716658
申请日：2015-05-19
发明人： Craig Graham
CPC分类号： G01N30/603 , B01D15/125 , B01D29/56 , B23K26/20 , B23K26/38 , Y10T29/49828
摘要： Frits for use in analytical instrument systems, including liquid chromatography systems, particularly HPLC and UHPLC systems, and methods of making and using the frits, are provided. The frits can have multiple layers, which may have different surface finishes on different surfaces.
摘要翻译： 提供了用于分析仪器系统的玻璃料，包括液相色谱系统，特别是HPLC和UHPLC系统，以及制备和使用玻璃料的方法。 玻璃料可以具有多个层，其可以在不同的表面上具有不同的表面光洁度。
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公开(公告)号：US09114335B1
公开(公告)日：2015-08-25
申请号：US12704741
申请日：2010-02-12
CPC分类号： B01D15/22 , G01N30/6026 , G01N30/603 , G01N30/6091 , Y10T29/49604
摘要： A reusable liquid chromatographic column consists of three parts, a column body with an integral outlet port molded on one end, a sealing insert with an inlet port, and a perforated cap providing downward force to compress the sealing insert into the column body. A wedge-like seal is employed to seal the connection between the sealing insert and the column body. Two filters on both ends of the column body are used to prevent escape of packing materials from the column chamber under pressure. Hand tightening is adequate to seal the connection by screwing the perforated cap onto the column body. The column is reusable due to its simple disassembling and reassembling processes. It is also disposable due to its inexpensive fabricating materials and manufacturing process.
摘要翻译： 可重复使用的液相色谱柱由三部分组成，柱体具有在一端模制的整体出口端口，具有入口端口的密封插入件和提供向下的力以将密封插入件压缩到柱体内的穿孔盖。 采用楔形密封来密封密封插入件和柱体之间的连接。 使用柱体两端的两个过滤器来防止包装材料在压力下从柱室逸出。 手拧紧足以通过将多孔盖螺栓拧到柱体上来密封连接。 该列由于其简单的拆卸和重新组装过程而可重复使用。 由于其廉价的制造材料和制造工艺，它也是一次性的。
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公开(公告)号：US20140152003A1
公开(公告)日：2014-06-05
申请号：US14232711
申请日：2012-08-23
申请人： Joseph D. Michienzi
发明人： Joseph D. Michienzi
CPC分类号： B05B5/16 , B01D15/10 , B01D15/1871 , B01D15/22 , G01N30/60 , G01N30/6004 , G01N30/6026 , G01N30/603 , G01N30/6039 , G01N30/6052 , G01N30/6095 , G01N30/7266 , Y10T29/49908
摘要： Described is a reusable fitting for attaching a conduit to a port. The fitting includes a housing, a spring, a retainer and cap. The retainer is capable of locking and unlocking a conduit in the fitting. The fitting provides a high pressure fluid-tight seal and a substantially zero void volume at the junction of two fluidic conduits. The fitting is removable, reusable and replaceable, and allows a user to make and remake connections of a capillary to a fluidic port without permanently binding a ferrule to a specific capillary and thus to a specific port. The fitting can be replaced if part or all of the fitting is damaged during use.
摘要翻译： 描述的是用于将导管附接到端口的可重复使用的配件。 配件包括壳体，弹簧，保持器和盖。 保持器能够锁定和解锁配件中的导管。 该配件在两个流体管道的连接处提供高压流体密封和基本为零的空隙体积。 该配件是可拆卸的，可重复使用的并且可更换的，并且允许使用者将毛细管连接到流体端口，而不必将套圈永久地固定到特定的毛细管，从而连接到特定的端口。 如果零件或全部配件在使用过程中损坏，可以更换配件。
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