公开(公告)号：US10654877B2

公开(公告)日：2020-05-19

申请号：US16459165

申请日：2019-07-01

申请人： MEDIVIR AB

发明人： Richard Bethell ,  Anders Eneroth ,  Bjorn Klasson ,  Fredrik Oberg

IPC分类号： A61K31/506 ,  C07F9/6558 ,  C07D405/04 ,  A61K31/675 ,  A61K45/06 ,  C07F9/24

摘要： The invention provides compounds of the formula: R1 is OR11, or NR5R5′; R2 is H or F; R5 is H, C1-C6alkyl, OH, C(═O)R6, O(C═O)R6 or O(C═O)OR6; R5′ is H or C1-C6alkyl; R6 is C1-C6alkyl or C3-C7cycloalkyl; R13 is H, phenyl, pyridyl, benzyl, indolyl or naphthyl wherein the phenyl, pyridyl, benzyl, indolyl and naphthyl is optionally substituted with 1, 2 or 3 R22; and the other variables are as defined in the claims, which are of use in the treatment of cancer, and related aspects.

公开(公告)号：US10336780B2

公开(公告)日：2019-07-02

申请号：US16208083

申请日：2018-12-03

申请人： MEDIVIR AB

发明人： Richard Bethell ,  Anders Eneroth ,  Bjorn Klasson ,  Fredrik Oberg

IPC分类号： C07D405/04 ,  C07F9/6558 ,  A61K45/06 ,  A61K31/675 ,  C07F9/24 ,  A61K31/506

摘要： The invention provides compounds of the formula: R1 is OR11, or NR5R5′;R2 is H or F;R5 is H, C1-C6alkyl, OH, C(═O)R6, O(C═O)R6 or O(C═O)OR6;R5 is H or C1-C6alkyl;R6 is C1-C6alkyl or C3-C7cycloalkyl;R13 is H, phenyl, pyridyl, benzyl, indolyl or naphthyl wherein the phenyl, pyridyl, benzyl, indolyl and naphthyl is optionally substituted with 1, 2 or 3 R22;and the other variables are as defined in the claims,which are of use in the treatment of cancer, and related aspects.

公开(公告)号：US11447511B2

公开(公告)日：2022-09-20

申请号：US17087483

申请日：2020-11-02

申请人： MEDIVIR AB

发明人： Richard Bethell ,  Anders Eneroth ,  Bjorn Klasson ,  Fredrik Oberg

IPC分类号： C07D405/04 ,  C07F9/6558 ,  A61K31/675 ,  A61K45/06 ,  A61K31/506 ,  C07F9/24

摘要： The invention provides compounds of the formula: R1 is OR11, or NR5R5′; R2 is H or F; R5 is H, C1-C6alkyl, OH, C(═O)R6, O(C═O)R6 or O(C═O)OR6; R5′ is H or C1-C6alkyl; R6 is C1-C6alkyl or C3-C7cycloalkyl; R13 is H, phenyl, pyridyl, benzyl, indolyl or naphthyl wherein the phenyl, pyridyl, benzyl, indolyl and naphthyl is optionally substituted with 1, 2 or 3 R22; and the other variables are as defined in the claims, which are of use in the treatment of cancer, and related aspects.

公开(公告)号：US10822360B2

公开(公告)日：2020-11-03

申请号：US16847477

申请日：2020-04-13

申请人： MEDIVIR AB

发明人： Richard Bethell ,  Anders Eneroth ,  Bjorn Klasson ,  Fredrik Oberg

IPC分类号： C07D405/04 ,  C07F9/6558 ,  C07F9/24 ,  A61K45/06 ,  A61K31/675 ,  A61K31/506

摘要： The invention provides compounds of the formula: R1 is OR11, or NR5R5′; R2 is H or F; R5 is H, C1-C6alkyl, OH, C(═O)R6, O(C═O)R6 or O(C═O)OR6; R5′ is H or C1-C6alkyl; R6 is C1-C6alkyl or C3-C7cycloalkyl; R13 is H, phenyl, pyridyl, benzyl, indolyl or naphthyl wherein the phenyl, pyridyl, benzyl, indolyl and naphthyl is optionally substituted with 1, 2 or 3 R22; and the other variables are as defined in the claims, which are of use in the treatment of cancer, and related aspects.

公开(公告)号：US10144750B2

公开(公告)日：2018-12-04

申请号：US15506692

申请日：2015-08-24

申请人： MEDIVIR AB

发明人： Richard Bethell ,  Anders Eneroth ,  Bjorn Klasson ,  Fredrik Oberg

IPC分类号： C07D405/04 ,  C07F9/6558 ,  A61K31/675 ,  A61K45/06

摘要： The invention provides compounds of the formula: R1 is OR11, or NR5R5′; R2 is H or F; R5 is H, OH, C1-C6 alkyl, OH, C(═O)R6, O(C═O)R6 or O(C═O)OR6; R5′ is H or C1-C6 alkyl; R6 is C1-C6 alkyl or C3-C7 cycloalkyl; R13 is H, phenyl, pyridyl, benzyl, indolyl or naphthyl wherein the phenyl, pyridyl, benzyl, indolyl and naphthyl is optionally substituted with 1, 2 or 3 R22; and the other variables are as defined in the claims, which are of use in the treatment of cancer, and related aspects.