公开(公告)号：US20220275017A1

公开(公告)日：2022-09-01

申请号：US17694180

申请日：2022-03-14

申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER

发明人： David Y. GIN ,  Eric K. CHEA ,  Alberto FERNANDEZ-TEJADA ,  Derek S. TAN ,  Jason S. LEWIS ,  Jeffrey R. GARDNER ,  NagaVaraKishore PILLARSETTY

IPC分类号： C07H15/256 ,  A61K39/39 ,  A61K45/06 ,  A61K31/7024 ,  C07H15/18 ,  C07H15/24 ,  A61K31/704

摘要： Truncated triterpene saponin analogues containing a trisaccharide or tetrasaccharide ester are disclosed. Also disclosed are pharmaceutical compositions comprising truncated saponin analogues and synthetic methods of producing the truncated saponin analogues. Another aspect of the present application relates to a method for immunizing a subject, comprising administering to the subject the pharmaceutical composition comprising a minimal saponin analogue and an antigen.

公开(公告)号：US20170096444A1

公开(公告)日：2017-04-06

申请号：US15314792

申请日：2015-06-01

申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER

发明人： David Y. GIN ,  Eric K. CHEA ,  Alberto FERNANDEZ-TEJADA ,  Derek S. TAN ,  Jason S. LEWIS ,  Jeffrey R. GARDNER ,  NagaVarakishore PILLARSETTY

IPC分类号： C07H15/256 ,  A61K45/06 ,  A61K31/704 ,  A61K39/39

CPC分类号： C07H15/256 ,  A61K31/7024 ,  A61K31/704 ,  A61K39/39 ,  A61K45/06 ,  A61K2039/55577 ,  A61K2300/00

摘要： Truncated triterpene saponin analogues containing a trisaccharide or tetrasaccharide ester are disclosed. Also disclosed are pharmaceutical compositions comprising truncated saponin analogues and synthetic methods of producing the truncated saponin analogues. Another aspect of the present application relates to a method for immunizing a subject, comprising administering to the subject the pharmaceutical composition comprising a minimal saponin analogue and an antigen.