-
公开(公告)号：US20220275017A1
公开(公告)日：2022-09-01
申请号：US17694180
申请日：2022-03-14
发明人： David Y. GIN , Eric K. CHEA , Alberto FERNANDEZ-TEJADA , Derek S. TAN , Jason S. LEWIS , Jeffrey R. GARDNER , NagaVaraKishore PILLARSETTY
IPC分类号： C07H15/256 , A61K39/39 , A61K45/06 , A61K31/7024 , C07H15/18 , C07H15/24 , A61K31/704
摘要： Truncated triterpene saponin analogues containing a trisaccharide or tetrasaccharide ester are disclosed. Also disclosed are pharmaceutical compositions comprising truncated saponin analogues and synthetic methods of producing the truncated saponin analogues. Another aspect of the present application relates to a method for immunizing a subject, comprising administering to the subject the pharmaceutical composition comprising a minimal saponin analogue and an antigen.
-
公开(公告)号：US20240327443A1
公开(公告)日：2024-10-03
申请号：US18733207
申请日：2024-06-04
发明人： David Y. GIN , Eric CHEA , Alberto FERNANDEZ-TEJADA , Jeffrey GARDNER , Jason LEWIS , Philip LIVINGSTON , J. Tyler MARTIN , Lars NORDSTROEM , Naga Vara Kishore PILLARSETTY , Govind RAGUPATHI , Derek TAN
IPC分类号： C07H1/00 , A61K31/7024 , A61K39/00 , A61K39/02 , A61K39/08 , A61K39/10 , A61K39/39 , A61P31/04 , C07H13/04 , C07H13/06 , C07H13/08 , C07J63/00
CPC分类号： C07H1/00 , A61K31/7024 , A61K39/08 , A61K39/099 , A61K39/39 , A61P31/04 , C07H13/04 , C07H13/06 , C07H13/08 , C07J63/008 , A61K2039/10 , A61K2039/55583
摘要： The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and methods of using said compounds or compositions in the treatment of and immunization for infectious diseases.
-
公开(公告)号：US20200239509A1
公开(公告)日：2020-07-30
申请号：US16827220
申请日：2020-03-23
发明人： David Y. GIN (Deceased) , Eric CHEA , Alberto FERNANDEZ-TEJADA , Jeffrey GARDNER , Jason LEWIS , Philip LIVINGSTON , J. Tyler MARTIN , Lars NORDSTROEM , Naga Vara Kishore PILLARSETTY , Govind RAGUPATHI , Derek TAN
IPC分类号： C07H1/00 , C07H13/08 , C07J63/00 , C07H13/04 , C07H13/06 , A61P31/04 , A61K31/7024 , A61K39/08 , A61K39/02 , A61K39/39
摘要： The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and methods of using said compounds or compositions in the treatment of and immunization for infectious diseases.
-
公开(公告)号：US20230219991A1
公开(公告)日：2023-07-13
申请号：US18180421
申请日：2023-03-08
发明人： David Y. GIN , Eric CHEA , Alberto FERNANDEZ-TEJADA , Jeffrey GARDNER , Jason LEWIS , Philip LIVINGSTON , J. Tyler MARTIN , Lars NORDSTROEM , Naga Vara Kishore PILLARSETTY , Govind RAGUPATHI , Derek TAN
IPC分类号： C07H1/00 , C07H13/04 , A61K39/02 , C07H13/06 , C07H13/08 , A61K31/7024 , C07J63/00 , A61K39/39 , A61P31/04 , A61K39/08 , A61K39/00 , A61K39/10
CPC分类号： C07H1/00 , C07H13/04 , A61K39/099 , C07H13/06 , C07H13/08 , A61K31/7024 , C07J63/008 , A61K39/39 , A61P31/04 , A61K39/08 , A61K2039/55583 , A61K2039/10
摘要： The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and methods of using said compounds or compositions in the treatment of and immunization for infectious diseases.
-
公开(公告)号：US20180112008A1
公开(公告)日：2018-04-26
申请号：US15558694
申请日：2016-03-16
CPC分类号： C07K16/3092 , A01K67/0275 , A01K2217/052 , A01K2217/15 , A01K2217/203 , A01K2227/105 , A01K2267/0331 , A61K39/0011 , A61P35/00 , C07K14/4727 , C07K16/2809 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N2800/30
摘要： Provided herein are compositions, methods, and uses involving antibodies that immunospecifically bind glycosylated forms of MUC16, a tethered mucin protein. Also provided herein are uses and methods for managing, treating, or preventing disorders, such as cancer.
-
公开(公告)号：US20230026100A1
公开(公告)日：2023-01-26
申请号：US17375048
申请日：2021-07-14
摘要： Provided herein are compositions, methods, and uses involving antibodies that immunospecifically bind glycosylated forms of MUC16, a tethered mucin protein. Also provided herein are uses and methods for managing, treating, or preventing disorders, such as cancer.
-
公开(公告)号：US20210002316A1
公开(公告)日：2021-01-07
申请号：US17005110
申请日：2020-08-27
发明人： David Y. GIN , Eric CHEA , Alberto FERNANDEZ-TEJADA , Jeffrey GARDNER , Jason LEWIS , Philip LIVINGSTON , J. Tyler MARTIN , Lars NORDSTROEM , Naga Vara Kishore PILLARSETTY , Govind RAGUPATHI , Derek TAN
IPC分类号： C07H1/00 , C07H13/08 , C07J63/00 , C07H13/04 , C07H13/06 , A61P31/04 , A61K31/7024 , A61K39/08 , A61K39/02 , A61K39/39
摘要： The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and methods of using said compounds or compositions in the treatment of and immunization for infectious diseases.
-
公开(公告)号：US20170096444A1
公开(公告)日：2017-04-06
申请号：US15314792
申请日：2015-06-01
发明人： David Y. GIN , Eric K. CHEA , Alberto FERNANDEZ-TEJADA , Derek S. TAN , Jason S. LEWIS , Jeffrey R. GARDNER , NagaVarakishore PILLARSETTY
IPC分类号： C07H15/256 , A61K45/06 , A61K31/704 , A61K39/39
CPC分类号： C07H15/256 , A61K31/7024 , A61K31/704 , A61K39/39 , A61K45/06 , A61K2039/55577 , A61K2300/00
摘要： Truncated triterpene saponin analogues containing a trisaccharide or tetrasaccharide ester are disclosed. Also disclosed are pharmaceutical compositions comprising truncated saponin analogues and synthetic methods of producing the truncated saponin analogues. Another aspect of the present application relates to a method for immunizing a subject, comprising administering to the subject the pharmaceutical composition comprising a minimal saponin analogue and an antigen.
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.026 秒)
