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Patent Agency Ranking
公开(公告)号：US10550190B2
公开(公告)日：2020-02-04
申请号：US15301564
申请日：2015-03-30
Applicant: Merck Sharp & Dohme Corp. , Ambrx, Inc.
Inventor： Robert M. Garbaccio , Jeffrey Kern , Philip E. Brandish , Sanjiv Shah , Linda Liang , Ying Sun , Jianing Wang , Nick Knudsen , Andrew Beck , Anthony Manibusan , Dennis Gately
Abstract: Phosphate-based linkers with tunable stability for intracellular delivery of drug conjugates are described. The phosphate-based linkers comprise a monophosphate, diphosphate, triphosphate, or tetraphosphate group (phosphate group) and a linker arm comprising a tuning element and optionally a spacer. A payload is covalently linked to the phosphate group at the distal end of the linker arm and the functional group at the proximal end of the linker arm is covalently linked to a cell-specific targeting ligand such as an antibody. These phosphate-based linkers have a differentiated and tunable stability in blood vs. an intracellular environment (e.g. lysosomal compartment).
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公开(公告)号：US11510993B2
公开(公告)日：2022-11-29
申请号：US15765515
申请日：2016-09-30
Applicant: Merck Sharp & Dohme Corp. , Ambrx, Inc.
Inventor： Philip E. Brandish , Robert M. Garbaccio , Jeffrey Kern , Linda Liang , Sanjiv Shah , Dennis Zaller , Andrew Beck , Dennis Gately , Nick Knudsen , Anthony Manibusan , Jianing Wang , Ying Sun
Abstract: Antibody drug conjugates (ADCs) comprising an antibody conjugated to an anti-inflammatory therapeutic agent via a phosphate-based linker with tunable extracellular and intracellular stability are described.
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公开(公告)号：US20200164085A1
公开(公告)日：2020-05-28
申请号：US15765515
申请日：2016-09-30
Applicant: Merck Sharp & Dohme Corp. , Ambrx, Inc.
Inventor： Philip E. Brandish , Robert M Garbaccio , Jeffrey Kern , Linda Liang , Sanjiv Shah , Dennis Zaller , Andrew Beck , Dennis Gately , Nick Knudsen , Anthony Manibusan , Jianing Wang , Ying Sun
Abstract: Antibody drug conjugates (ADCs) comprising an antibody conjugated to an anti-inflammatory therapeutic agent via a phosphate-based linker with tunable extracellular and intracellular stability are described.
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公开(公告)号：US20170182181A1
公开(公告)日：2017-06-29
申请号：US15301564
申请日：2015-03-30
Applicant: MERCK SHARP & DOHME CORP. , AMBRX, INC.
Inventor： Robert M. Garbaccio , Jeffrey Kern , Philip E. Brandish , Sanjiv Shah , Linda Liang , Ying Sun , Jianing Wang , Nick Knudsen , Andrew Beck , Anthony Manibusan , Dennis Gately
CPC classification number: C07K16/2866 , A61K47/6803 , A61K47/6817 , A61K47/6849 , A61K47/6889 , A61K51/1045 , C07F9/091 , C07F9/098 , C07F9/12 , C07F9/2458 , C07F9/572 , C07F9/65517 , C07F9/65583 , C07F9/65586 , C07F9/6561 , C07H19/10
Abstract: Phosphate-based linkers with tunable stability for intracellular delivery of drug conjugates are described. The phosphate-based linkers comprise a monophosphate, diphosphate, triphosphate, or tetraphosphate group (phosphate group) and a linker arm comprising a tuning element and optionally a spacer. A payload is covalently linked to the phosphate group at the distal end of the linker arm and the functional group at the proximal end of the linker arm is covalently linked to a cell-specific targeting ligand such as an antibody. These phosphate-based linkers have a differentiated and tunable stability in blood vs. an intracellular environment (e.g. lysosomal compartment).
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公开(公告)号：US20230099074A1
公开(公告)日：2023-03-30
申请号：US18049711
申请日：2022-10-26
Applicant: Merck Sharp & Dohme LLC , Ambrx, Inc.
Inventor： Philip E. Brandish , Robert M. Garbaccio , Jeffrey Kern , Linda Liang , Sanjiv Shah , Dennis Zaller , Andrew Beck , Dennis Gately , Nick Knudsen , Anthony Manibusan , Jianing Wang , Ying Sun
Abstract: Antibody drug conjugates (ADCs) comprising an antibody conjugated to an anti-inflammatory therapeutic agent via a phosphate-based linker with tunable extracellular and intracellular stability are described.
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