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公开(公告)号：US11485966B2
公开(公告)日：2022-11-01
申请号：US16754713
申请日：2017-10-11
发明人： Hui Wang , Xun Xu , Jin Yang , Ao Chen , Chongjun Xu , Wenwei Zhang
摘要： The present invention provides a method for improving the loading of nucleic acid on a solid support by contacting the solid support with a poloxamer-containing reagent. The present invention also provides a method for improving the stability of a nucleic acid on a solid support, comprising contacting a nucleic acid molecule with a partially double-strand oligonucleotide before or after loading the nucleic acid molecule on a solid support, so as to cause the nucleic acid molecule to hybridize with the oligonucleotide. The present invention also provides a combined use of the two methods.
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公开(公告)号：US20230272467A1
公开(公告)日：2023-08-31
申请号：US18144121
申请日：2023-05-05
发明人： Jin Yang , Xun Xu , Hui Wang , Bin Xie , Zhuokun Li , Shengming Zhao , Ao Chen , Chongjun Xu , Wenwei Zhang , Ming Ni
IPC分类号： C12Q1/6869 , C12Q1/6876 , G01N21/64
CPC分类号： C12Q1/6869 , C12Q1/6876 , G01N21/6486 , B01L2200/10
摘要： The present invention provides a method for sequencing a nucleic acid using an immersion reaction protocol. The immersion reaction protocol comprises sequentially immersing a solid support having nucleic acid molecules immobilized thereon in different reaction containers to realize nucleic acid sequencing.
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公开(公告)号：US11692221B2
公开(公告)日：2023-07-04
申请号：US16635131
申请日：2017-08-01
发明人： Jin Yang , Xun Xu , Hui Wang , Bin Xie , Zhuokun Li , Shengming Zhao , Ao Chen , Chongjun Xu , Wenwei Zhang , Ming Ni
IPC分类号： C12Q1/6869 , C12Q1/6876 , G01N21/64
CPC分类号： C12Q1/6869 , C12Q1/6876 , G01N21/6486 , B01L2200/10
摘要： The present invention provides a method for sequencing a nucleic acid using an immersion reaction protocol. The immersion reaction protocol comprises sequentially immersing a solid support having nucleic acid molecules immobilized thereon in different reaction containers to realize nucleic acid sequencing.
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