公开(公告)号：US20200338004A1

公开(公告)日：2020-10-29

申请号：US16760406

申请日：2018-10-31

Applicant: MODERNATX, INC.

Inventor： Kenny Mikael Hansson ,  Kerry Benenato ,  Maria Wågberg ,  Annika Pålsson ,  Regina Fritsche-Danielson

IPC: A61K9/127 ,  A61P43/00 ,  A61K9/00 ,  A61K31/7088 ,  A61K38/18

Abstract: The disclosure relates to nanoparticles comprising a lipid component and a modified RNA encoding a VEGF-A polypeptide. Aspects of the disclosure further relate to uses of nanoparticles comprising a lipid component and a modified RNA encoding a VEGF-A polypeptide, for improving wound healing in a subject.

公开(公告)号：US11696892B2

公开(公告)日：2023-07-11

申请号：US16760406

申请日：2018-10-31

Applicant: ModernaTX, Inc.

Inventor： Kenny Mikael Hansson ,  Kerry Benenato ,  Maria Wågberg ,  Annika Pålsson ,  Regina Fritsche-Danielson

IPC: A61K9/127 ,  A61P43/00 ,  A61K31/7088 ,  A61K38/18 ,  B82Y5/00 ,  A61K9/00

CPC classification number: A61K9/1272 ,  A61K9/0019 ,  A61K31/7088 ,  A61K38/1866 ,  A61P43/00 ,  B82Y5/00

Abstract: The disclosure relates to nanoparticles comprising a lipid component and a modified RNA encoding a VEGF-A polypeptide. Aspects of the disclosure further relate to uses of nanoparticles comprising a lipid component and a modified RNA encoding a VEGF-A polypeptide, for improving wound healing in a subject.