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公开(公告)号：US20180346592A1
公开(公告)日：2018-12-06
申请号：US15771527
申请日：2016-10-27
Applicant: MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH
Inventor： Jae Chan PARK , Kisu KIM , Mijung LEE , Eun-Hee LEE , Dong-Sik KIM , Eun Jung SONG , Sujeong KIM , Hyung-Kwon LIM , Kyuhyun LEE , Jongwha WON , Soongyu CHOI , Young Seoub PARK
CPC classification number: C07K16/303 , A61K47/6859 , C07K2317/31 , C07K2317/622
Abstract: The present invention relates to an antibody specifically binding to glypican 3 (GPC3), a nucleic acid encoding the antibody, a vector and a host cell containing the nucleic acid, a method of preparing the antibody, and a pharmaceutical composition for treating cancer or tumor, containing the antibody as an active ingredient. The antibody specifically binding to glypican 3 according to the present invention may be effectively used to treat cancer or tumor, particularly, hepatocellular carcinoma due to high affinity and specificity to glypican 3.
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公开(公告)号：US20180346588A1
公开(公告)日：2018-12-06
申请号：US15762885
申请日：2016-09-23
Inventor： Dong-Sik KIM , Eun Jung SONG , Mijung LEE , Eun-Hee LEE , Miyoung OH , Jae Chan PARK , Kisu KIM , Sujeong KIM , Hyung-Kwon LIM , Kyuhyun LEE , Jongwha WON , Soongyu CHOI , Young Seoub PARK
IPC: C07K16/30
CPC classification number: C07K16/30 , C07K16/18 , C07K2317/21 , C07K2317/565 , C07K2317/92
Abstract: The present invention relates to an antibody specifically bound to mesothelin (MSLN), a nucleic acid encoding the antibody, a vector and a host cell including the nucleic acid, a method for producing the antibody, and a pharmaceutical composition for treating cancer or tumor including the antibody as an active ingredient. The antibody specifically bound to the mesothelin according to the present invention has high affinity and specificity to an antigen, such that it is possible to develop an antibody effectively usable for treatment or diagnosis of cancer or tumor diseases.
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公开(公告)号：US20180030151A1
公开(公告)日：2018-02-01
申请号：US15553292
申请日：2015-12-29
Applicant: MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH
Inventor： Dong-Sik KIM , Mi Jung LEE , Jae Chan PARK , Sumin LEE , Heechun KWAK , SungHo HWANG , Hyung-Kwon LIM , Kisu KIM , Young Seoub PARK , Junhong JEONG , Ki Joon CHO
IPC: C07K16/38
CPC classification number: C07K16/38 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/72 , C07K2317/92
Abstract: The present invention relates to an antibody that binds specifically to a tissue factor pathway inhibitor (TFPI), a nucleic acid encoding the antibody, a vector comprising the nucleic acid, a host cell transformed with the vector, a method for producing the antibody, and a pharmaceutical composition for treating hemophilia, which comprises the antibody as an active ingredient. The antibody of the present invention, which binds specifically to TFPI, can activate the extrinsic pathway of blood coagulation by inhibiting TFPI. Thus, the antibody of the present invention can be effectively used for the treatment of antibody-induced hemophilia patients and for the prevention of blood coagulation disease in hemophilia-A or hemophilia-B patients.
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