公开(公告)号：US20220372491A1

公开(公告)日：2022-11-24

申请号：US17772107

申请日：2020-10-28

Applicant: MONASH UNIVERSITY

Inventor： Denny COTTLE ,  Ian SMYTH ,  Ming Shen THAM

IPC: C12N15/113 ,  A61P13/12 ,  C12Q1/6883

Abstract: The present invention relates to compositions, methods, uses and kits for the treatment of renal cystogenesis. In particular, the compositions, methods, uses and kits are particularly useful, but not limited to, the treatment or prevention of Polycystic Kidney Disease. In one aspect, the prevent invention provides a method of minimising or delaying renal cystogenesis in a subject in need thereof, the method comprising inhibiting AKT in the subject, or reducing the level of Aurora kinase in the subject, thereby minimising or delaying renal cystogenesis.

公开(公告)号：US20180263940A1

公开(公告)日：2018-09-20

申请号：US15557405

申请日：2016-03-16

Applicant: MONASH UNIVERSITY

Inventor： Ian SMYTH ,  Denny COTTLE ,  Gloria URSINO

IPC: A61K31/196 ,  A61K9/00 ,  A61P17/06 ,  A61P17/16 ,  A61K47/44

CPC classification number: A61K31/196 ,  A61K9/0014 ,  A61K31/195 ,  A61K31/202 ,  A61K31/203 ,  A61K31/232 ,  A61K31/4436 ,  A61K31/606 ,  A61K47/06 ,  A61K47/10 ,  A61K47/26 ,  A61K47/44 ,  A61K2300/00 ,  A61P17/06 ,  A61P17/16

Abstract: The present invention relates to compositions, methods and kits for the treatment of dermopathies. In particular, the compositions, methods and kits are particularly useful, but not limited to, the treatment of ichthyoses such as Harlequin Ichthyosis. The present invention provides a method of treating a skin condition associated with lipid dysfunction, the method comprising administering to a subject in need thereof aminosalicyclic acid (ASA), ASA derivative, or pharmaceutically acceptable salt, ester, amide, polymorph and/or prodrug thereof, thereby treating a skin condition associated with lipid dysfunction. Preferably, the skin condition associated with lipid dysfunction is an ichthyoses, for example Harlequin Ichthyosis. Preferably, the ASA is mesalamine.