公开(公告)号：US20230227580A1

公开(公告)日：2023-07-20

申请号：US18000557

申请日：2021-06-25

Applicant: MONASH UNIVERSITY ,  BAKER HEART AND DIABETES INSTITUTE

Inventor： Christoph HAGEMEYER ,  Erik WESTEIN ,  Thomas HOEFER ,  Robert ANDREWS ,  Elizabeth GARDINER

IPC: C07K16/36 ,  A61P7/02

CPC classification number: C07K16/36 ,  A61P7/02 ,  C07K2317/76 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622

Abstract: The invention also relates to antigen binding proteins and related fragments thereof for binding Von Willebrand factor (VWF) and uses thereof. In one aspect, the present invention provides an antigen binding protein comprising an antigen binding domain that binds to or specifically binds to Von Willebrand factor (VWF) under shear gradient conditions. Preferably, the antigen binding protein comprises an antigen binding domain that does not bind to VWF under constant shear conditions.