公开(公告)号：US20240141360A1

公开(公告)日：2024-05-02

申请号：US18310289

申请日：2023-05-01

Applicant: MONASH UNIVERSITY ,  MURDOCH UNIVERSITY

Inventor： Stephen WILTON ,  Merlin Christopher THOMAS ,  Carlos ROSADO ,  Raelene Jane PICKERING

IPC: C12N15/113

CPC classification number: C12N15/1138 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3233 ,  C12N2310/3513 ,  C12N2320/30 ,  C12N2320/33

Abstract: An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.

公开(公告)号：US20230015481A1

公开(公告)日：2023-01-19

申请号：US17930364

申请日：2022-09-07

Applicant: MONASH UNIVERSITY ,  MURDOCH UNIVERSITY

Inventor： Stephen WILTON ,  Merlin Christopher THOMAS ,  Carlos ROSADO ,  Raelene Jane PICKERING

IPC: C12N15/113

Abstract: An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.

公开(公告)号：US20210388363A1

公开(公告)日：2021-12-16

申请号：US17411932

申请日：2021-08-25

Applicant: MONASH UNIVERSITY ,  MURDOCH UNIVERSITY

Inventor： Stephen WILTON ,  Merlin Christopher THOMAS ,  Carlos ROSADO ,  Raelene Jane PICKERING

IPC: C12N15/113

Abstract: An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.

公开(公告)号：US20250019415A1

公开(公告)日：2025-01-16

申请号：US18802964

申请日：2024-08-13

Applicant: Monash University ,  The University of Western Australia

Inventor： Kevin Donald George PFLEGER ,  Merlin Christopher THOMAS ,  Raelene Jane PICKERING ,  Carlos Joaquin ROSADO ,  Christos TIKELLIS

IPC: C07K14/72 ,  A61K38/00 ,  A61P29/00 ,  C07K14/705

Abstract: A method of screening candidate agents for their ability to modulate RAGE activity where such RAGE activity is induced by an active co-located GPCR, the method comprising the steps of: contacting a RAGE polypeptide with a GPCR polypeptide in the presence of a candidate agent where the GPCR polypeptide is constitutively active and/or is activated by addition of an agonist, partial agonist or allosteric modulator of that GPCR; and detecting whether the candidate agent is a modulator of RAGE ligand-independent activation of RAGE by activated co-located GPCR by detecting an effect indicative of modulation of RAGE activation by the presence of the candidate agent and/or by detecting RAGE-dependent signalling that is modulated by the presence of the candidate agent.

公开(公告)号：US20220169693A1

公开(公告)日：2022-06-02

申请号：US17312317

申请日：2019-12-10

Applicant: Monash University ,  The University of Western Australia

Inventor： Kevin Donald George PFLEGER ,  Merlin Christopher THOMAS ,  Raelene Jane PICKERING ,  Carlos ROSADO ,  Elizabeth Katherine Mary JOHNSTONE

IPC: C07K14/705 ,  C12N15/85

Abstract: The invention relates to modulators of activation of Immunoglobulin Superfamily Cell Adhesion Molecules (IgSF CAMs) and modulators of activation of Receptor for Advanced Glycation End Products (RAGE) as well as screening assays for identifying modulators of activation of molecules associated with certain diseases and/or conditions in which IgSF CAMs and/or RAGE are implicated, and to medicaments and methods of treatment comprising administration of such modulators.

公开(公告)号：US20200207836A1

公开(公告)日：2020-07-02

申请号：US16641174

申请日：2018-08-21

Applicant: Monash University ,  The University of Western Australia

Inventor： Kevin Donald George PFLEGER ,  Merlin Christopher THOMAS ,  Raelene Jane PICKERING ,  Carlos ROSADO ,  Christos TIKELLIS

IPC: C07K14/72 ,  C07K14/705

Abstract: A method of screening candidate agents for their ability to modulate RAGE activity where such RAGE activity is induced by an active co-located GPCR, the method comprising the steps of: contacting a RAGE polypeptide with a GPCR polypeptide in the presence of a candidate agent where the GPCR polypeptide is constitutively active and/or is activated by addition of an agonist, partial agonist or allosteric modulator of that GPCR; and detecting whether the candidate agent is a modulator of RAGE ligand-independent activation of RAGE by activated co-located GPCR by detecting an effect indicative of modulation of RAGE activation by the presence of the candidate agent and/or by detecting RAGE-dependent signalling that is modulated by the presence of the candidate agent.