公开(公告)号：US20230312577A1

公开(公告)日：2023-10-05

申请号：US18000632

申请日：2021-06-04

Applicant: MONASH UNIVERSITY ,  PETER MACCALLUM CANCER INSTITUTE

Inventor： Philip THOMPSON ,  Jake SHORTT ,  Ricky JOHNSTONE ,  Xiao MA ,  Danielle OH ,  Ian JENNINGS

IPC: C07D487/04 ,  C07D495/04 ,  C07D471/04 ,  A61P35/00

CPC classification number: C07D487/04 ,  C07D495/04 ,  C07D471/04 ,  A61P35/00

Abstract: Provided herein are compounds of Formula (I) that are dual inhibitors of kinases and bromo-domain proteins. The disclosure also relates to pharmaceutical compositions containing such compounds, methods for using such compounds in the treatment of cancers, particularly, the treatment of multiple myeloma cancers, and to related uses.