公开(公告)号：US3655869A

公开(公告)日：1972-04-11

申请号：US3655869D

申请日：1969-01-02

Applicant: MONSANTO CO

Inventor： WHARTON FERDINAND D ,  JOHNSON JOHN H ,  FIELDS JOSEPH E ,  MACHLIN LAWRENCE J

IPC: A61K31/785 ,  A61K27/00

CPC classification number: A61K31/785

Abstract: THE TREATMENT OR PREVENTION OF GASTRO-ENTERITIS DIARRHEAL SYNDROME (IDARRHEA) IN A LIVING ANIMAL BODY IS ACCOMPLISHED BY ORALY ADMINISTERING TO SAID ANIMAL BODY A THERAPEUTICALLY EFFECTIVE AMOUNT OF A BASIC POLYELECTROLYTE POLYMER, WHICH IS (A) A POLYMERIZED UNSATURATED CARBOXYLIC ACID OR ANHYDRIDE AND A DERIVATIVE OF A POLYMERIZED UNSATURATED CARBOXYLIC ACID OR ANHYDRIDE, (B) A DERIVATIVE OF A POLYMERIZED UNSATURATED CARBOXYLIC ACID OR ANHYDRIDE OR (C) A COPOLYMER OF (1) AN UNSATURATED MONOMER HAVING 2 TO 18 CARBON ATOMS AND (2) A MONOMER SELECTED FROM THE GROUP CONSISTING OF (A) AN UNSATURATED CARBOXYLIC ACID OR ANHYDRIDE AND A DERIVATIVE OF AN UNSATURATED CARBOXYLIC ACID OR NHYDRIDE AND (B) A DERIVATIVE OF AN UNSATURATED CARBOXYLIC ACID OR ANHYDRIDE, AS EXEMPLIFIED BY N,N-DIMETHYLAMINOPROPYLIMIDE OF ETHYLENE/MALEIC ANHYDRIDE COPOLYMER. THE BASIC POLYMER IS POLYCATIONIC OR POLYAMPHOLYTIC IN NATURE. TYPICAL DOSAGE IS 0.05 TO 5.0% OF THE TOTAL DIET.